Anti-alpha-Smooth Muscle Actin antibody (monoclonal)
Mouse IgG monoclonal antibody for alpha-Smooth Muscle Actin, actin, alpha 2, smooth muscle, aorta (ACTA2 ) detection. Tested with WB, IHC-P, IHC-F in Human;mouse;rat. No cross reactivity with other proteins.
|Immunogen||N-terminal synthetic decapeptide of alpha-smooth muscle actin.|
|Storage||At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.|
|Reactivity||Human, Mouse, Rat|
|Cross Reactivity||No cross reactivity with other proteins|
|Protein Name||Actin, aortic smooth muscle|
|Gene Full Name||actin, alpha 2, smooth muscle, aorta|
|Synonyms||AAT6|ACTSA|MYMY5|ACTSA|alpha-cardiac actin|cell growth-inhibiting gene 46 protein|
|Uniprot ID||Human(P62736, Mouse)|
|Application||IHC-P, IHC-F, WB|
|Ig type||Mouse IgG2a|
|Concentration||1.2% sodium acetate or neutral PBS. If 1ml of PBS is used, the antibody concentration will be 100ug/ml.|
Ueyama et al.(1990) assigned the ACTSA gene to chromosome 10 by Southern blot analysis of DNAs from 18 rodent-human somatic cell hybrids. Regional mapping by in situ hybridization localized the gene to 10q22-q24.Assignment of the vascular smooth muscle actin gene ACTSA to human chromosome. Smooth muscle alpha-actin gene requires two E-boxes for proper expression in vivo and is a target of class I basic helix-loop-helix proteins.
Boster Scientific References
Physical properties of poly(N-isopropylacrylamide) hydrogel promote its effects on cardiac protection after myocardial infarction.
Suppression of CB1 cannabinoid receptor by lentivirus mediated small interfering RNA ameliorates hepatic fibrosis in rats.
1,25-Dihydroxyvitamin D(3) (1,25-(OH)(2)D(3)) attenuates airway remodeling in a murine model of chronic asthma.
Clinicopathological and prognostic significance of epithelial mesenchymal transition-related protein expression in intrahepatic cholangiocarcinoma.
Role of TGF-β1/Smads pathway in carotid artery remodeling in renovascular hypertensive rats and prevention by Enalapril and Amlodipine.
Ameliorative effect of grape seed proanthocyanidin extract on thioacetamide-induced mouse hepatic fibrosis.
Hepatocyte growth factor-induced amelioration in chronic renal failure is associated with reduced expression of α-smooth muscle actin.
VEGF induces proliferation of human hair follicle dermal papilla cells through VEGFR-2-mediated activation of ERK.
Antagonist of microRNA-21 improves balloon injury-induced rat iliac artery remodeling by regulating proliferation and apoptosis of adventitial fibroblasts and myofibroblasts.
Ginsenoside Rb₁ inhibits the carotid neointimal hyperplasia induced by balloon injury in rats via suppressing the phenotype modulation of vascular smooth muscle cells.
Endothelialization and in-stent restenosis on the surface of glycoprotein IIIa monoclonal antibody eluting stent.
Prostaglandin E1 dose-dependently promotes stability of atherosclerotic plaque in a rabbit model.
MeCP2 controls the expression of RASAL1 in the hepatic fibrosis in rats.
Exosomes derived from human bone marrow mesenchymal stem cells promote tumor growth in vivo.
Up-regulation of VEGF by small activator RNA in human corpus cavernosum smooth muscle cells.
Blocking core fucosylation of TGF-β1 receptors downregulates their functions and attenuates the epithelial-mesenchymal transition of renal tubular cells.
Complete estrogen receptor blocker ICI182,780 promotes the proliferation of vascular smooth muscle cells.
Atorvastatin attenuates inflammatory infiltration and vascular remodeling in lung of hypercholesterolemia rabbits.
Role of LOX-1 and ROS in oxidized low-density lipoprotein induced epithelial-mesenchymal transition of NRK52E.
Haemin-enhanced expression of haem oxygenase-1 stabilizes erythrocyte-induced vulnerable atherosclerotic plaques.
Leukamenin F suppresses liver fibrogenesis by inhibiting both hepatic stellate cell proliferation and extracellular matrix production.
Comparison of fibrogenesis caused by dermal and adipose tissue injury in an experimental model.
Gene expression profiles during activation of cultured rat hepatic stellate cells by tumoral hepatocytes and fetal bovine serum.
Berberine inhibits hepatic stellate cell proliferation and prevents experimental liver fibrosis.
Advanced oxidation protein products induce vascular calcification by promoting osteoblastic trans-differentiation of smooth muscle cells via oxidative stress and ERK pathway.
Enhanced external counterpulsation inhibits intimal hyperplasia by modifying shear stress responsive gene expression in hypercholesterolemic pigs.
Proliferation and pluripotency potential of ectomesenchymal cells derived from first branchial arch.
Notch signaling may negatively regulate neonatal rat cardiac fibroblast-myofibroblast transformation.
Duodenum clamping trauma induces significant postoperative intraperitoneal adhesions on a rat model.
Emodin protects rat liver from CCl(4)-induced fibrogenesis via inhibition of hepatic stellate cells activation.
The peripheral cannabinoid receptor 1 antagonist VD60 efficiently inhibits carbon tetrachloride-intoxicated hepatic fibrosis progression.
Expression and cellular distribution of TLR4, MyD88, and NF-_B in diabetic renal tubulointerstitial fibrosis, in vitro and in vivo.
Probucol attenuates ethanol-induced liver fibrosis in rats by inhibiting oxidative stress, extracellular matrix protein accumulation and cytokine production.
Vitamin K1 attenuates bile duct ligation-induced liver fibrosis in rats.
Function of the transforming growth factor-_1/c-Jun N-terminal kinase signaling pathway in the action of thalidomide on a rat model of pulmonary fibrosis.