Anti-alpha-Smooth Muscle Actin antibody (monoclonal)

Product code: MA1106 $200 In stock Boster Citations: 142 Datasheet Protocols Write a Review
Price: $200.00


Product Name Anti-alpha-Smooth Muscle Actin antibody (monoclonal)
Description Mouse IgG monoclonal antibody for alpha-Smooth Muscle Actin, actin, alpha 2, smooth muscle, aorta (ACTA2 ) detection. Tested with WB, IHC-P, IHC-F in Human;mouse;rat. No cross reactivity with other proteins.
Species Human, Mouse, Rat
Application IHC-P, IHC-F, WB
Recommended Detection Systems Boster recommends Enhanced Chemiluminescent Kit with anti-Mouse IgG (EK1001) for Western blot, and HRP Conjugated anti-Mouse IgG Super Vision Assay Kit (SV0001-1) for IHC(P) and IHC(F).
*Blocking peptide can be purchased at $50. Contact us for more information
Immunogen N-terminal synthetic decapeptide of alpha-smooth muscle actin.
Specificity No cross reactivity with other proteins
Pack Size 100μg/vial


Clonality Monoclonal
Clone Number 1A4
Form Lyophilized
Contents Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.
*carrier free antibody available upon request.
Reconstitution Add 1ml of PBS buffer will yield a concentration of 100ug/ml.
Storage At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.
Purification Ascites

Application Details

Application Concentration* Tested Species Predicted Species Antigen Retrieval
Western blot2μg/mlHuman, mouse, rat-
Immunohistochemistry(Paraffin-embedded Section)0.1-0.5μg/mlHuman, mouse, rat-By Heat
Immunohistochemistry(Frozen Section)0.1-0.5μg/mlHuman, mouse, rat-

Other applications have not been tested.

Optimal dilutions should be determined by end users.

**Boster provides high sensitivity secondary antibody kits for Western blotting and IHC. For more info see Related Products below.

Related products

Protein Target Info (Source:

Gene Name 1867
Protein Name Actin, aortic smooth muscle
Gene Full Name actin, alpha 2, smooth muscle, aorta
Protein Function Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Subcellular Localization Cytoplasm, cytoskeleton.
Uniprot ID Human(P62736), Mouse(P62737), Rat(P62738)
Alternative Names Actin, aortic smooth muscle|ACTA2|Actin,aorticsmoothmuscle|actin
*if product is indicated to react with multiple species, protein info is based on the human gene.

Background for Actin, aortic smooth muscle (1867)

Ueyama et al.(1990) assigned the ACTSA gene to chromosome 10 by Southern blot analysis of DNAs from 18 rodent-human somatic cell hybrids. Regional mapping by in situ hybridization localized the gene to 10q22-q24.Assignment of the vascular smooth muscle actin gene ACTSA to human chromosome. Smooth muscle alpha-actin gene requires two E-boxes for proper expression in vivo and is a target of class I basic helix-loop-helix proteins.
Write a review for MA1106

Only registered users can write reviews. Please, log in or register

Personal Information

Login Information

* Required Fields


Vitamin K1 attenuates bile duct ligation-induced liver fibrosis in rats.
Binding of prorenin to (pro)renin receptor induces the proliferation of human umbilical artery smooth muscle cells via ROS generation and ERK1/2 activation.
DNMT3A silencing RASSF1A promotes cardiac fibrosis through upregulation of ERK1/2.
Cardamonin inhibits angiotensin II-induced vascular smooth muscle cell proliferation and migration by downregulating p38 MAPK, Akt, and ERK phosphorylation.
1, 25-Dihydroxyvitamin D3 (1, 25-(OH) 2D3) Attenuates Airway Remodeling in a Murine Model of Chronic Asthma
2-Methoxyestradiol inhibits bleomycin-induced systemic sclerosis through suppression of fibroblast activation
3, 4-dihydroxyphenylethanol suppresses irradiation-induced pulmonary fibrosis in adult rats
A role of 1, 25 (OH) 2 D 3 supplementation in rats with nonalcoholic steatohepatitis induced by choline-deficient diet
A synthetic cantharidin analog for the enhancement of doxorubicin suppression of stem cell-derived aggressive sarcoma
Activation of Protein Serine/Threonine Phosphatase PP2Ca Efficiently Prevents Liver Fibrosis
Advanced oxidation protein products accelerate renal fibrosis in a remnant kidney model
Ameliorative effect of grape seed proanthocyanidin extract on thioacetamide-induced mouse hepatic fibrosis
An improved method for guinea pig airway smooth muscle cell culture and the effect of SPFF on intracellular calcium
Antagonist of microRNA-21 improves balloon injury-induced rat iliac artery remodeling by regulating proliferation and apoptosis of adventitial fibroblasts and …
Anti-fibrosis effects of Huisheng oral solution in CCl4-induced hepatic fibrosis in rat
Antifibrotic effects of crocetin in scleroderma fibroblasts and in bleomycin-induced sclerotic mice
Arsenic trioxide prevents rat pulmonary fibrosis via miR-98 overexpression
Assessing the validity of a novel model of vertebral artery type of cervical syndrome induced by injecting sclerosing agent next to transverse process of cervical …
Atorvastatin attenuates inflammatory infiltration and vascular remodeling in lung of hypercholesterolemia rabbits
Berberine inhibits hepatic stellate cell proliferation and prevents experimental liver fibrosis
Biocompatible surgical meshes based on decellularized human amniotic membrane
BMP-7 attenuates liver fibrosis via regulation of epidermal growth factor receptor
Bone marrow mesenchymal stem cells ameliorate rat acute renal failure by differentiation into renal tubular epithelial-like cells
Bone marrow stem cells implantation with a-cyclodextrin/MPEG
Bone marrow-derived cells can acquire renal stem cells properties and ameliorate ischemia-reperfusion induced acute renal injury
Caffeine protects against alcohol-induced liver fibrosis by dampening the cAMP/PKA/CREB pathway in rat hepatic stellate cells
Chronic inhibition of cyclic guanosine monophosphate-specific phosphodiesterase 5 prevented cardiac fibrosis through inhibition of transforming growth factor - …
Circumferentially aligned fibers guided functional neoartery regeneration in vivo
Clinicopathological and prognostic significance of epithelial mesenchymal transition-related protein expression in intrahepatic cholangiocarcinoma
Combination of keratins and alpha-smooth muscle actin distinguishes secretory coils from ducts of eccrine sweat glands
Combinational therapy of interferon-a and chemotherapy normalizes tumor vasculature by regulating pericytes including the novel marker RGS5 in melanoma
Comparison of fibrogenesis caused by dermal and adipose tissue injury in an experimental model
Continuous Passages Accelerate the Reprogramming of Mouse Induced Pluripotent Stem Cells
C-reactive protein/oxidised low-density lipoprotein/beta2-glycoprotein I complex promotes atherosclerosis in diabetic BALB/c mice via p38mitogen-activated …
Curcumin Ameliorates Renal Fibrosis by Inhibiting Local Fibroblast Proliferation and Extracellular Matrix Deposition
Delta-like 1 serves as a new target and contributor to liver fibrosis down-regulated by mesenchymal stem cell transplantation
Dexamethasone prevents monocyte-induced tubular epithelial
Different responses of cell cycle between rat vascular smooth muscle cells and vascular endothelial cells to paclitaxel
Differentiation of human umbilical cord mesenchymal stem cells into hepatocyte-like cells by hTERT gene transfection in vitro
Distribution, development and proliferation of interstitial cells of Cajal in murine colon: an immunohistochemical study from neonatal to adult life
DNA methylation and MeCP2 regulation of PTCH1 expression during rats hepatic fibrosis
DNMT1-mediated PTEN hypermethylation confers hepatic stellate cell activation and liver fibrogenesis in rats
Dual-delivery of VEGF and PDGF by double-layered electrospun membranes for blood vessel regeneration
Duodenum Clamping Trauma Induces Significant Postoperative Intraperitoneal Adhesions on a Rat Model
Dynamic Contrast-Enhanced Magnetic Resonance Imaging with Gd-EOB-DTPA for the Evaluation of Liver Fibrosis Induced by Carbon Tetrachloride in Rats
Effect of dietary fiber/starch balance on the cecal proteome of growing rabbits
Effects of hydroxysafflor yellow A on proliferation and collagen synthesis of rat vascular adventitial fibroblasts induced by angiotensin II
Effects of mesenchymal stem cells transplanted at different time points in a rat remnant kidney model
Effects of PPAR-a agonist and IGF-1 on estrogen sulfotransferase in human vascular endothelial and smooth muscle cells
Effects of total flavonoids from Dracocephalum moldavica on the proliferation, migration, and adhesion molecule expression of rat vascular smooth muscle cells …
Endothelialization and in-stent restenosis on the surface of glycoprotein IIIa monoclonal
Endothelialization and patency of RGD-functionalized vascular grafts in a rabbit carotid artery model
Engineering blood vessels through micropatterned co-culture of vascular endothelial and smooth muscle cells on bilayered electrospun fibrous mats with pDNA …
Ephrin-B2 mediates trophoblast-dependent maternal spiral artery remodeling in first trimester
Erythropoietin augments the efficacy of therapeutic angiogenesis induced by allogenic bone marrow stromal cells in a rat model of limb ischemia
Expression and cellular distribution of TLR4, MyD88, and NF-B in diabetic renal tubulointerstitial fibrosis, in vitro and in vivo
FAK activity is required for HGF to suppress TGF-1-induced cellular proliferation
Function of the transforming growth factor?
Haemin-enhanced expression of haem oxygenase-1 stabilizes erythrocyte-induced vulnerable atherosclerotic plaques
Heme oxygenase/carbon monoxide pathway inhibition plays a role in ameliorating fibrosis following splenectomy
Hepatocyte growth factor modification promotes the amelioration effects of human umbilical cord mesenchymal stem cells on rat acute kidney injury
Hepatocyte growth factor-induced amelioration in chronic renal failure is associated with reduced expression of a-smooth muscle actin
Immobilization of heparin/poly-l-lysine nanoparticles on dopamine-coated surface to create a heparin density gradient for selective direction of platelet and vascular …
Increased adenosine levels contribute to ischemic kidney fibrosis in the unilateral ureteral obstruction model
Inhibition of hepatic fibrosis with artificial microRNA using ultrasound and cationic liposome-bearing microbubbles
Inhibition of Janus kinase-2 signalling pathway ameliorates portal hypertensive syndrome in partial portal hypertensive and liver cirrhosis rats
Inhibition of TRPM7 channels prevents proliferation and differentiation of human lung fibroblasts
Injection of composite with bone marrow-derived mesenchymal stem cells and a novel synthetic hydrogel after myocardial infarction: A protective role in left ventricle …
Leukamenin F suppresses liver fibrogenesis by inhibiting both hepatic stellate cell proliferation and extracellular matrix production
Ligustrazine attenuates the platelet
Lipopolysaccharide inhibits the self-renewal of spermatogonial stem cells in vitro via downregulation of GDNF expression in Sertoli cells
Matrigel basement membrane matrix induces eccrine sweat gland cells to reconstitute sweat gland-like structures in nude mice
Matrix metalloproteinase-9 induces cardiac fibroblast migration, collagen and cytokine secretion: inhibition by salvianolic acid B from Salvia miltiorrhiza
MeCP2 controls the expression of RASAL1 in the hepatic fibrosis in rats
Mest attenuates CCl4-induced liver fibrosis in rats by inhibiting the Wnt/??-catenin signaling pathway
MicroRNA-200a controls Nrf2 activation by target Keap1 in hepatic stellate cell proliferation and fibrosis
Mig-6 Gene Knockout Induces Neointimal Hyperplasia in the Vascular Smooth Muscle Cell
miR-21-3p regulates cardiac hypertrophic response by targeting histone deacetylase-8
Myocardial angiogenesis after chronic ghrelin treatment in a rat myocardial infarction model
NS5ATP9 Suppresses Activation of Human Hepatic Stellate Cells, Possibly via Inhibition of Smad3/Phosphorylated-Smad3 Expression
Ovarian cancer-associated fibroblasts contribute to epithelial ovarian carcinoma metastasis by promoting angiogenesis, lymphangiogenesis and tumor cell invasion
Overexpression of SOX2 promotes migration, invasion, and epithelial-mesenchymal transition through the Wnt/-catenin pathway in laryngeal cancer Hep-2 cells
Oxidative stress-induced 1, N6-ethenodeoxyadenosine adduct formation contributes to hepatocarcinogenesis
Postnatal development of interstitial cells of Cajal in mouse colon in response to Kit signal blockade with Imatinib (Glivec
Probucol attenuates ethanol
Protection against TGF--induced fibrosis effects of IL-10 on dermal fibroblasts and its potential therapeutics for the reduction of skin scarring
Protective effect of salvianolic acid B on chronic pancreatitis induced by trinitrobenzene sulfonic acid solution in rats
Rapamycin slows IgA nephropathy progression in the rat
Relaxant effect of flavonoid naringenin on contractile activity of rat colonic smooth muscle
Robo1/2 regulate follicle atresia through manipulating granulosa cell apoptosis in mice
Role of bone morphogenetic proteins in form-deprivation myopia sclera
Role of LOX-1 and ROS in oxidized low-density lipoprotein induced epithelial-mesenchymal transition of NRK52E
RoY Peptide-Modified Chitosan-Based Hydrogel to Improve Angiogenesis and Cardiac Repair under Hypoxia
Salvianolic acid A, a novel matrix metalloproteinase-9 inhibitor, prevents cardiac remodeling in spontaneously hypertensive rats
Schistosoma japonicum egg antigen up-regulates fibrogenesis and inhibits proliferation in primary hepatic stellate cells in a concentration-dependent manner
Smad2 protects against TGF-1/Smad3-mediated collagen synthesis in human hepatic stellate cells during hepatic fibrosis
Sodium ferulate lowers portal pressure in rats with secondary biliary cirrhosis through the RhoA/Rho-kinase signaling pathway: A preliminary study
Soluble transforming growth factor- receptor II might inhibit transforming growth factor-induced myofibroblast differentiation and improve ischemic cardiac function …
Sorcin Enhances Metastasis and Promotes Epithelial-to-Mesenchymal Transition of Colorectal Cancer
SOX9 Overexpression Promotes Glioma Metastasis via Wnt/-Catenin Signaling
Stat3 signaling activation crosslinking of TGF-1 in hepatic stellate cell exacerbates liver injury and fibrosis
Study on the in vitro and in vivo activation of rat hepatic stellate cells by Raman spectroscopy
Substrate stiffness influences TGF--induced differentiation of bronchial fibroblasts into myofibroblasts in airway remodeling
Synthesis, characterization and cytocompatibility of a degradable polymer using ferric catalyst for esophageal tissue engineering
Targeted inhibition of platelet-derived growth factor receptor-subunit in hepatic stellate cells ameliorates hepatic fibrosis in rats
Targeted NGF siRNA delivery attenuates sympathetic nerve sprouting and deteriorates cardiac dysfunction in rats with myocardial infarction
Tetramethylpyrazine inhibits angiotensin II
Tetramethylpyrazine reduces glucose and insulin-induced activation of hepatic stellate cells by inhibiting insulin receptor-mediated PI3K/AKT and ERK pathways
TGF-1-elevated TRPM7 channel regulates collagen expression in hepatic stellate cells via TGF-1/Smad pathway
The effect of thick fibers and large pores of electrospun poly (-caprolactone) vascular grafts on macrophage polarization and arterial regeneration
The imperatorin derivative OW1, a new vasoactive compound, inhibits VSMC proliferation and extracellular matrix hyperplasia
The peripheral cannabinoid receptor 1 antagonist VD60 efficiently inhibits carbon tetrachloride-intoxicated hepatic fibrosis progression
The rhythmic expression of clock genes attenuated in human plaque-derived vascular smooth muscle cells
The role of ERK and JNK signaling in connective tissue growth factor induced extracellular matrix protein production and scar formation
Therapeutic angiogenesis in ischemic muscles after local injection of fragmented fibers with loaded traditional Chinese medicine
Therapeutic Potential of Umbilical Cord Mesenchymal Stem Cells for Inhibiting Myofibroblastic Differentiation of Irradiated Human Lung Fibroblasts
TRPM7 channel regulates PDGF-BB-induced proliferation of hepatic stellate cells via PI3K and ERK pathways
TRPV4 channel inhibits TGF-??1-induced proliferation of hepatic stellate cells
Tumourigenesis in the infarcted rat heart is eliminated through differentiation and enrichment of the transplanted embryonic stem cells
Vascular Normalization Induced by Sinomenine Hydrochloride Results in Suppressed Mammary Tumor Growth and Metastasis
Wnt/catenin pathway forms a negative feedback loop during TGF- induced human normal skin fibroblast-to-myofibroblast transition
Xia-yu-xue decoction (XYXD) reduces carbon tetrachloride (CCl 4)-induced liver fibrosis through inhibition hepatic stellate cell activation by targeting NF-??B …
Chlorogenicacid inhibits hypoxia-induced pulmonary artery smooth muscle cells proliferation via c-Src and Shc/Grb2/ERK2 signaling pathway
Protective effects of astaxanthin against ischemia/reperfusion induced renal injury in mice
Cryptotanshinone, an orally bioactive herbal compound from Danshen, attenuates atherosclerosis in apolipoprotein E-deficient mice: role of lectin-like oxidized LDL receptor-1 (LOX-1)
Rho-Associated Protein Kinases Play an Important Role in the Differentiation of Rat Adipose-Derived Stromal Cells into Cardiomyocytes In Vitro
Acute downregulation of miR-155 at wound sites leads to a reduced fibrosis through attenuating inflammatory response
Involvement of IL-13 and tissue transglutaminase in liver granuloma and fibrosis after schistosoma japonicum infection.
The green tea extract epigallocatechin-3-gallate inhibits irradiation-induced pulmonary fibrosis in adult rats
Expressionof the tissue inhibitor of metalloproteinase-3 by transplanted VSMCs modifies heart structure and function after myocardial infarction
Directed differentiation of aged human bone marrow multipotent stem cells effectively generates dopamine neurons
In vitro constitution of esophageal muscle tissue with endocyclic and exolongitudinal patterns
Mesenchymal stem-like cells isolated from human esophageal carcinoma and adjacent non-cancerous tissues
Lentiviral vector-mediated down-regulation of IL-17A receptor in hepatic stellate cells results in decreased secretion of IL-6
Suppression of lipopolysaccharide-induced upregulation of toll-like receptor 4 by emodin in mouse proximal tubular epithelial cells
VEGF induces proliferation of human hair follicle dermal papilla cells through VEGFR-2-mediated activation of ERK
Scutellarin inhibits translocation of protein kinase C in diabetic thoracic aorta of the rat
Injectable biodegradable hybrid hydrogels based on thiolated collagen and oligo(acryloyl carbonate)–poly(ethylene glycol)–oligo(acryloyl carbonate) copolymer for functional cardiac regeneration
Role of Wnt/β-catenin Signaling Pathway in the Mechanism of Calcification of Aortic Valve
Thymic Stromal Lymphopoietin Attenuates the Development of Atherosclerosis in ApoE−/− Mice