Anti-BAK/BAK1 Antibody Picoband™ (monoclonal, 4C2)

BAK antibody

Boster Bio Anti-BAK/BAK1 Antibody Picoband™ (monoclonal, 4C2) catalog # M01163-1. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. Cited in 1 publication(s).

Product Info Summary

SKU: M01163-1
Size: 100 μg/vial
Reactive Species: Human, Mouse, Rat
Host: Mouse
Application: Flow Cytometry, IF, IHC, ICC, WB

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Product Name

Anti-BAK/BAK1 Antibody Picoband™ (monoclonal, 4C2)

View all BAK Antibodies

SKU/Catalog Number

M01163-1

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-BAK/BAK1 Antibody Picoband™ (monoclonal, 4C2) catalog # M01163-1. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-BAK/BAK1 Antibody Picoband™ (monoclonal, 4C2) (Boster Biological Technology, Pleasanton CA, USA, Catalog # M01163-1)

Host

Mouse

Contents

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Clonality

Monoclonal

Clone Number

4C2

Isotype

Mouse IgG2b

Immunogen

E.coli-derived human BAK/BAK1 recombinant protein (Position: A22-S211). Human BAK shares 78.3 % amino acid (aa) sequence identity with mouse BAK.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross Reactivity

No cross reactivity with other proteins.

Reactive Species

M01163-1 is reactive to BAK1 in Human, Mouse, Rat

Applications

M01163-1 is guaranteed for Flow Cytometry, IF, IHC, ICC, WB Boster Guarantee

Background of BAK

BAK, officially called Bcl2 antagonist killer, is a protein that in humans, encoded by the BAK gene. The BAK protein is a pro-apoptotic member of the Bcl-2 gene family which is involved in initiating apoptosis. BAK gene spans 7.6 kb and contains 6 exons. By Southern blot analysis of genomic DNA from human/rodent somatic cell hybrids, BAK gene is localized to chromosome 6. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence and ELISA with known positive and negative samples to ensure specificity and high affinity.

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Reconsitution

Add 0.2ml of distilled water will yield a concentration of 500μg/ml.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. Actual working concentration varies and should be decided by the user.

Western blot, 0.1-0.5μg/ml
Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml
Immunocytochemistry/Immunofluorescence, 2μg/ml
Flow Cytometry, 1-3μg/1x106 cells

Validation Images & Assay Conditions

Gene/Protein Information For BAK1 (Source: Uniprot.org, NCBI)

Uniprot ID

Q16611

Gene ID

578

Gene Name

BAK1

Full Name

Bcl-2 homologous antagonist/killer

Weight

23.409kDa

Superfamily

Bcl-2 family

Alternative Names

Apoptosis regulator BAK; BAK; BAK1; BAK-LIKE; BAKMGC3887; BCL2-antagonist/killer 1; BCL2L7; bcl2-L-7; BCL2L7bcl-2 homologous antagonist/killer; BCL2-like 7 protein; Bcl-2-like protein 7; CDN1; MGC117255; pro-apoptotic protein BAK BAK1 BAK, BAK-LIKE, BCL2L7, CDN1 BCL2 antagonist/killer 1 bcl-2 homologous antagonist/killer|BCL2-like 7 protein|apoptosis regulator BAK|bcl-2-like protein 7|bcl2-L-7|pro-apoptotic protein BAK

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on BAK1, check out the BAK1 Infographic

BAK1 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for BAK1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected]

M01163-1 has been cited in 1 publications:

*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.

BAK overexpression mediates p53-independent apoptosis inducing effects on human gastric cancer cells

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SKU:M01163-1

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M01163-1
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$315.00

$50 fee for conjugation. Antibody size is reduced to 50ug.

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