Rabbit IgG polyclonal antibody for C-type lectin domain family 4 member K (CD207) detection.tested for IF, IHC in Human, Mouse, Rat.
Anti-Langerin/CD207 Antibody Info At A Glance
|Reactivity:||Human, Mouse, Rat|
|Product Name||Anti-Langerin/CD207 Antibody
See all Langerin/CD207 primary antibodies, ELISA kits and proteins
|Storage & Handling||At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.|
|Description||Polyclonal antibody for Langerin/Cd207 detection. Host: Rabbit.Size: 100μl. Tested applications: IF. Reactive species: Human. Langerin/Cd207 information: Molecular Weight: 37621 MW; Subcellular Localization: Membrane; Single-pass type II membrane protein. Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes; Tissue Specificity: Expressed by Langerhans cells. Expressed in dendritic cells and by scattered cells in lymph nodes and spleen. Also detected in some non-lymphoid tissues such as lung, liver and heart.|
|Cite This Product||Anti-Langerin/CD207 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02316)|
|Similar Products From
|Anti-Langerin/CD207 Antibody may replace the following items: sc 33768|sc 22623|sc 22622|sc 271272|sc 33767|sc 22620.|
|Reactivity/Species||Human, Mouse, Rat|
*Our Boster Guarantee covers the use of this product in the above tested applications.
*Innovating Scientists reward: if you test this antibody on a species or application not listed above and share with us your results, we will provide you a full credit to purchase Boster products.
|Immunogen||KLH conjugated synthetic peptide derived from human CD207 213-223 amino acid.|
Gene/Protein Basic Information For Cd207 (Source: Uniprot.org, NCBI)
|NCBI Gene Id||246278|
|Species Of This Entry||Mouse|
|Protein Name||C-type lectin domain family 4 member K|
|Alternative Names||Langerin/CD207|CD207 antigen; CD207 antigen, langerin; CD207 molecule, langerin; CD207; CLEC4KLangerhans cell specific c-type lectin; C-type lectin domain family 4 member K; C-type lectin domain family 4, member K; Langerin|
|Post Tranlational Modifications||Glycosylation; Ribosylation|
|Gene Location||6|6 C3, on Chromasome 6, gene sequence:|
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
Ontology For Cd207 (Source: Uniprot.org, NCBI)
|Protein Function||Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells.|
|Tissue Specificity||Expressed by Langerhans cells. Expressed in dendritic cells and by scattered cells in lymph nodes and spleen. Also detected in some non-lymphoid tissues such as lung, liver and heart.|
|Related Diseases||Neoplasms; Histiocytosis, Langerhans-cell; Inflammation; Histiocytosis; Hiv Infections; Diphtheria; Contact Dermatitis; Contact Hypersensitivity; Carcinoma; Malignant Neoplasms; Malignant Paraganglionic Neoplasm; Infective Disorder; Dermatitis; Tissue Adhesions; Dermatologic Disorders; Immunologic Deficiency Syndromes; Sarcoma; Decreased Immunologic Activity [pe]; Lymphoma|
|Related Pathways||Immune Response; Pathogenesis; Hypersensitivity; Localization; Transport; Cell Activation; Endocytosis; Sensitization; Cell Differentiation; Adaptive Immune Response; Secretion; Cytokine Production; Cell Adhesion; Cell Migration; T Cell Activation; Mast Cell Activation; Wound Healing; Receptor-mediated Endocytosis; Skin Morphogenesis; Cell Proliferation|
|Scientific References||PMID: 11777972 by Valladeau J., et al. Identification of mouse langerin/CD207 in Langerhans cells and some dendritic cells of lymphoid tissues.|
PMID: 18322168 by Idoyaga J., et al. Langerin/CD207 receptor on dendritic cells mediates efficient antigen presentation on MHC I and II products in vivo.
Our Boster Quality Guarantee for Anti-Langerin/CD207 Antibody covers its use in the following applications.IHC-P, 1:100-500
*The recommended dilution ratios/concentrations are for reference only and optimal dilutions/concentrations should be determined by the end user.
Formalin-fixed and paraffin embedded rat vascular endothelial cells labeled with Anti-LangerinCD207 Polyclonal Antibody followed by conjugation to the secondary antibody Goat Anti-Rabbit IgG, FITC Conjugated
Formalin-fixed and paraffin embedded human cervical carcinoma labeled with Anti-LangerinCD207 Polyclonal Antibody at 1:200 followed by conjugation to the secondary antibody and DAB staining
Boster provides comprehensive technical information for WB, IHC/IF/ICC, Flow Cytometry sample preparation protocols, assay protocols, troubleshooting tips and assay optimization tips.
- Western Blottting Resource Center
- Immunohistochemistry Resource Center
- Flow Cytometry Technical Resource Center
Other Recommended Resources
Here are featured tools and databases that you might find useful.
Order Product (A02316)
Domestically in USA and Canada, ships next business day if available in stock.
Note: sample size takes longer to process, average 5-7 days.
All Boster antibodies and ELISA kits are guaranteed to meet the specifications on the data sheet.See Details
Download troubleshooting handbooks for IHC, Western blot and ELISA for FREE.Download Free PDFs Now
Guaranteed product quality
We promise all of our products perform as described in datasheets.