Anti-CDK5R1/P35 Antibody

CDK5 Activator 1 antibody

Boster Bio Anti-CDK5R1/P35 Antibody (Catalog # A02595). Tested in WB, IF applications. This antibody reacts with Human, Mouse, Rat.

Product Info Summary

SKU: A02595
Size: 100 µl
Reactive Species: Human, Mouse, Rat
Host: Rabbit
Application: IF, WB

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Product Name

Anti-CDK5R1/P35 Antibody

View all CDK5 Activator 1 Antibodies

SKU/Catalog Number

A02595

Size

100 µl

Form

Liquid

Description

Boster Bio Anti-CDK5R1/P35 Antibody (Catalog # A02595). Tested in WB, IF applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-CDK5R1/P35 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02595)

Host

Rabbit

Contents

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from internal of human CDK5R1.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A02595 is reactive to CDK5R1 in Human, Mouse, Rat

Applications

A02595 is guaranteed for IF, WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

34.06kDa

Background of CDK5 Activator 1

p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.

Tsai L.-H., Nature 371:419-423(1994).
Patrick G.N., Nature 402:615-622(1999).
Kesavapany S., J. Neurosci. 24:4421-4431(2004).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blotting: 1:500~1:3000

Immunofluorescence: 1:100~1:500

Validation Images & Assay Conditions

Gene/Protein Information For CDK5R1 (Source: Uniprot.org, NCBI)

Gene Name

CDK5R1

Full Name

Cyclin-dependent kinase 5 activator 1

Weight

34.06kDa

Superfamily

cyclin-dependent kinase 5 activator family

Alternative Names

CDK5 Activator 1; CDK5P35; CDK5R; CDK5R1; cyclin-dependent kinase 5 activator 1; Cyclin-dependent kinase 5 regulatory subunit 1; cyclin-dependent kinase 5, regulatory subunit 1 (p35); MGC33831; NCK5A; Neuronal CDK5 Activator; p23; p25; p35; p35nck5a; regulatory partner for CDK5 kinase; tau protein kinase II 23kDa subunit; TPKII Regulatory Subunit CDK5R1 CDK5P35, CDK5R, NCK5A, p23, p25, p35, p35nck5a cyclin dependent kinase 5 regulatory subunit 1 cyclin-dependent kinase 5 activator 1|CDK5 activator 1|TPKII regulatory subunit|neuronal CDK5 activator|regulatory partner for CDK5 kinase|tau protein kinase II 23kDa subunit

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on CDK5R1, check out the CDK5R1 Infographic

CDK5R1 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for CDK5R1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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5 Customer Q&As for Anti-CDK5R1/P35 Antibody

Question

Is this A02595 anti-CDK5R1/P35 antibody reactive to the isotypes of CDK5R1?

Verified Customer

Verified customer

Asked: 2020-05-01

Answer

The immunogen of A02595 anti-CDK5R1/P35 antibody is Synthesized peptide derived from internal of human CDK5R1. Could you tell me which isotype you are interested in so I can help see if the immunogen is part of this isotype?

Boster Scientific Support

Answered: 2020-05-01

Question

We are currently using anti-CDK5R1/P35 antibody A02595 for mouse tissue, and we are happy with the WB results. The species of reactivity given in the datasheet says human, mouse, rat. Is it true that the antibody can work on zebrafish tissues as well?

Verified Customer

Verified customer

Asked: 2018-10-15

Answer

The anti-CDK5R1/P35 antibody (A02595) has not been validated for cross reactivity specifically with zebrafish tissues, though there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in zebrafish you can get your next antibody for free. Please contact me if I can help you with anything.

Boster Scientific Support

Answered: 2018-10-15

Question

Here is the WB image, lot number and protocol we used for neocortex using anti-CDK5R1/P35 antibody A02595. Please let me know if you require anything else.

T. Collins

Verified customer

Asked: 2018-01-18

Answer

Thank you very much for the data. Our lab team are working to resolve this as quickly as possible, and we appreciate your patience and understanding! You have provided everything we needed. Please let me know if there is anything you need in the meantime.

Boster Scientific Support

Answered: 2018-01-18

Question

I am interested in to test anti-CDK5R1/P35 antibody A02595 on human neocortex for research purposes, then I may be interested in using anti-CDK5R1/P35 antibody A02595 for diagnostic purposes as well. Is the antibody suitable for diagnostic purposes?

Verified Customer

Verified customer

Asked: 2017-05-30

Answer

The products we sell, including anti-CDK5R1/P35 antibody A02595, are only intended for research use. They would not be suitable for use in diagnostic work. If you have the means to develop a product into diagnostic use, and are interested in collaborating with us and develop our product into an IVD product, please contact us for more discussions.

Boster Scientific Support

Answered: 2017-05-30

Question

I see that the anti-CDK5R1/P35 antibody A02595 works with IF, what is the protocol used to produce the result images on the product page?

B. Jackson

Verified customer

Asked: 2013-09-19

Answer

You can find protocols for IF on the "support/technical resources" section of our navigation menu. If you have any further questions, please send an email to [email protected]

Boster Scientific Support

Answered: 2013-09-19

Order DetailsPrice
A02595-100uL

100uL

$360

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