Anti-CHM Antibody Picoband™

CHM antibody

Boster Bio Anti-CHM Antibody Picoband™ catalog # A00814-1. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Info Summary

SKU: A00814-1
Size: 100 μg/vial
Reactive Species: Human, Mouse, Rat
Host: Rabbit
Application: ELISA, WB

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Product Name

Anti-CHM Antibody Picoband™

View all CHM Antibodies

SKU/Catalog Number

A00814-1

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-CHM Antibody Picoband™ catalog # A00814-1. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-CHM Antibody Picoband™ (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00814-1)

Host

Rabbit

Contents

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

E. coli-derived human CHM recombinant protein (Position: A193-Q380).

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins.

Reactive Species

A00814-1 is reactive to CHM in Human, Mouse, Rat

Applications

A00814-1 is guaranteed for ELISA, WB Boster Guarantee

Observed Molecular Weight

73 kDa

Calculated molecular weight

73.476kDa

Background of CHM

Rab escort protein 1 (REP1) also known as rab proteins geranylgeranyltransferase component A 1 is an enzyme that in humans is encoded by the CHM gene. This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane. Mutations in this gene are a cause of choroideremia; also known as tapetochoroidal dystrophy (TCD). This X-linked disease is characterized by progressive dystrophy of the choroid, retinal pigment epithelium and retina. Alternatively spliced transcript variants have been found for this gene.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Innovating Scientists Reward

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Reconsitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blot, 0.1-0.5μg/ml
Direct ELISA, 0.1-0.5μg/ml

Validation Images & Assay Conditions

Gene/Protein Information For CHM (Source: Uniprot.org, NCBI)

Gene Name

CHM

Full Name

Rab proteins geranylgeranyltransferase component A 1

Weight

73.476kDa

Superfamily

Rab GDI family

Alternative Names

choroideraemia protein; choroideremia (Rab escort protein 1); Rab geranylgeranyltransferase component A; rab proteins geranylgeranyltransferase component A 1; REP1 CHM DXS540, GGTA, HSD-32, REP-1, TCD CHM Rab escort protein rab proteins geranylgeranyltransferase component A 1|CHM, Rab escort protein 1|choroideremia (Rab escort protein 1)

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on CHM, check out the CHM Infographic

CHM infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for CHM: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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4 Customer Q&As for Anti-CHM Antibody Picoband™

Question

Is a blocking peptide available for product anti-CHM antibody (A00814-1)?

Verified Customer

Verified customer

Asked: 2020-02-21

Answer

We do provide the blocking peptide for product anti-CHM antibody (A00814-1). If you would like to place an order for it please contact [email protected] and make a special request.

Boster Scientific Support

Answered: 2020-02-21

Question

Does anti-CHM antibody A00814-1 work on monkey ELISA with retina?

Verified Customer

Verified customer

Asked: 2018-05-11

Answer

Our lab technicians have not validated anti-CHM antibody A00814-1 on monkey. You can run a BLAST between monkey and the immunogen sequence of anti-CHM antibody A00814-1 to see if they may cross-react. If the sequence homology is close, then you can perform a pilot test. Keep in mind that since we have not validated monkey samples, this use of the antibody is not covered by our guarantee. However we have an innovator award program that if you test this antibody and show it works in monkey retina in ELISA, you can get your next antibody for free.

Boster Scientific Support

Answered: 2018-05-11

Question

See below the WB image, lot number and protocol we used for retina using anti-CHM antibody A00814-1. Please let me know if you require anything else.

Verified Customer

Verified customer

Asked: 2018-02-16

Answer

Thank you very much for the data. Our lab team are working to resolve this as quickly as possible, and we appreciate your patience and understanding! You have provided everything we needed. Please let me know if there is anything you need in the meantime.

Boster Scientific Support

Answered: 2018-02-16

Question

Is this A00814-1 anti-CHM antibody reactive to the isotypes of CHM?

S. Johnson

Verified customer

Asked: 2017-04-19

Answer

The immunogen of A00814-1 anti-CHM antibody is E. coli-derived human CHM recombinant protein (Position: A193-Q380). Could you tell me which isotype you are interested in so I can help see if the immunogen is part of this isotype?

Boster Scientific Support

Answered: 2017-04-19

Order DetailsPrice
A00814-1

100μg

$370
A00814-1-10ug

10μg sample (liquid)

$99
A00814-1-Biotin

100 μg Biotin conjugated

$570
A00814-1-Cy3

100 μg Cy3 conjugated

$570
A00814-1-Dylight488

100 μg Dylight488 conjugated

$570
A00814-1-Dylight550

100 μg Dylight550 conjugated

$570
A00814-1-Dylight594

100 μg Dylight594 conjugated

$570
A00814-1-FITC

100 μg FITC conjugated

$570
A00814-1-HRP

100 μg HRP conjugated

$570
A00814-1-APC

100 μg APC conjugated

$670
A00814-1-PE

100 μg PE conjugated

$670
A00814-1-carrier-free

Carrier Free

$370

More conjugates/formats

Free Secondary Antibody

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Eddy test
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A00814-1
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$370.00

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