Anti-COL25A1/Clacp Antibody

Collagen XXV alpha 1 antibody

Boster Bio Anti-COL25A1/Clacp Antibody catalog # A08068. Tested in WB applications. This antibody reacts with Human, Mouse.

Product Info Summary

SKU: A08068
Size: 100μl
Reactive Species: Human, Mouse
Host: Rabbit
Application: WB

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Product Name

Anti-COL25A1/Clacp Antibody

View all Collagen XXV alpha 1 Antibodies

SKU/Catalog Number

A08068

Size

100μl

Form

Liquid

Description

Boster Bio Anti-COL25A1/Clacp Antibody catalog # A08068. Tested in WB applications. This antibody reacts with Human, Mouse.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-COL25A1/Clacp Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A08068)

Host

Rabbit

Contents

PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.

Clonality

Polyclonal

Clone Number

1A3

Isotype

IgG

Immunogen

Synthetic peptide from AA range: 101-150.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A08068 is reactive to Col25a1 in Human, Mouse

Applications

A08068 is guaranteed for WB Boster Guarantee

Observed Molecular Weight

39 kDa

Calculated molecular weight

65.377kDa

Background of Collagen XXV alpha 1

Skp/Cullin/F-box (SCF) complexes are part of a large family of E3 ubiquitin ligases in which F-box proteins determine substrate specificity. Substrate selection by F-box proteins may also be aided by accessory cofactors. The F-box only protein 4, FBX4, interacts via its F-box with SKP1 and CUL1 to form SCFFBX4 ubiquitin ligase. The activity of the SCFFBX4 complex can be regulated by aB crystallin, a small heat shock protein which serves as a specificity cofactor for FBX4 dependent ubiquitination. FBX4 together with aB crystallin (SCFFBX4-aB crystallin) promotes the ubiquitination of cyclin D1 phosphorylated at Thr-286. In addition, the SCFFBX4-aB crystallin ubiquitin ligase has been implicated in the ubiquitination of unknown substrates in desmin-related myopathy. SCFFBX4, in the absence of aB crystallin, also ubiquitinates the telomeric protein PIN2/TRF1.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB, 1:5000-10000

Validation Images & Assay Conditions

Gene/Protein Information For Col25a1 (Source: Uniprot.org, NCBI)

Gene Name

Col25a1

Full Name

Collagen alpha-1(XXV) chain

Weight

65.377kDa

Alternative Names

Alzheimer disease amyloid-associated protein; AMY; CLAC; CLACP; CLAC-P; COL25A1; Collagen 25; collagen alpha-1(XXV) chain; Collagen XXV alpha 1; collagen, type XXV, alpha 1; Collagen-25; collagen-like Alzheimer amyloid plaque component; collagenous Alzheimer amyloid plaque component

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on Col25a1, check out the Col25a1 Infographic

Col25a1 infographic

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In this infographic, you will see the following information for Col25a1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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3 Customer Q&As for Anti-COL25A1/Clacp Antibody

Question

I am looking for to test anti-COL25A1/Clacp antibody A08068 on mouse left testis for research purposes, then I may be interested in using anti-COL25A1/Clacp antibody A08068 for diagnostic purposes as well. Is the antibody suitable for diagnostic purposes?

Verified Customer

Verified customer

Asked: 2020-04-10

Answer

The products we sell, including anti-COL25A1/Clacp antibody A08068, are only intended for research use. They would not be suitable for use in diagnostic work. If you have the means to develop a product into diagnostic use, and are interested in collaborating with us and develop our product into an IVD product, please contact us for more discussions.

Boster Scientific Support

Answered: 2020-04-10

Question

We are currently using anti-COL25A1/Clacp antibody A08068 for mouse tissue, and we are happy with the WB results. The species of reactivity given in the datasheet says human, mouse. Is it possible that the antibody can work on bovine tissues as well?

Verified Customer

Verified customer

Asked: 2020-01-29

Answer

The anti-COL25A1/Clacp antibody (A08068) has not been tested for cross reactivity specifically with bovine tissues, though there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in bovine you can get your next antibody for free. Please contact me if I can help you with anything.

Boster Scientific Support

Answered: 2020-01-29

Question

We appreciate helping with my inquiry over the phone. Here are the WB image, lot number and protocol we used for left testis using anti-COL25A1/Clacp antibody A08068. Let me know if you need anything else.

Verified Customer

Verified customer

Asked: 2019-12-27

Answer

Thanks for the data. You have provided everything we needed. Our lab team are working to resolve your inquiry as quickly as possible, and we appreciate your patience and understanding! Please let me know if there is anything you need in the meantime.

Boster Scientific Support

Answered: 2019-12-27

Order DetailsPrice
A08068

100uL

$399

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