Anti-alpha 1 Catenin/CTNNA1 Antibody Picoband™

Catenin alpha 1 antibody

Boster Bio Anti-alpha 1 Catenin/CTNNA1 Antibody Picoband™ catalog # PB9137. Tested in Flow Cytometry, IF, IHC, IHC-F, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. Cited in 2 publication(s).

Product Info Summary

SKU: PB9137
Size: 100 μg/vial
Reactive Species: Human, Mouse, Rat
Host: Rabbit
Application: Flow Cytometry, IF, IHC, IHC-F, ICC, WB

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Product Name

Anti-alpha 1 Catenin/CTNNA1 Antibody Picoband™

View all Catenin alpha 1 Antibodies

SKU/Catalog Number

PB9137

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-alpha 1 Catenin/CTNNA1 Antibody Picoband™ catalog # PB9137. Tested in Flow Cytometry, IF, IHC, IHC-F, ICC, WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-alpha 1 Catenin/CTNNA1 Antibody Picoband™ (Boster Biological Technology, Pleasanton CA, USA, Catalog # PB9137)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

E.coli-derived human CTNNA1 recombinant protein (Position: D143-D292). Human CTNNA1 shares 98% amino acid (aa) sequence identity with mouse CTNNA1.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

PB9137 is reactive to CTNNA1 in Human, Mouse, Rat

Applications

PB9137 is guaranteed for Flow Cytometry, IF, IHC, IHC-F, ICC, WB Boster Guarantee

Observed Molecular Weight

100 kDa

Calculated molecular weight

100.071kDa

Background of Catenin alpha 1

CTNNA1, also known as Catenin alpha-1 or Catenin (cadherin-associated protein), alpha 1, is a protein that in humans is encoded by the CTNNA1 gene. It is mapped to 5q31.2. When surface epithelium CTNNA1 was ablated, hair follicle development was blocked and epidermal morphogenesis was dramatically affected, with defects in adherens junction formation, intercellular adhesion, and epithelial polarity. In vitro, CTNNA1 null keratinocytes were poorly contact inhibited and grew rapidly. These differences were not dependent upon intercellular adhesion and were in marked contrast to keratinocytes conditionally null for another essential intercellular adhesion protein, desmoplakin Knockout keratinocytes exhibited sustained activation of the Ras-MAPK cascade due to aberrations in growth factor responses. It is concluded that features of precancerous lesions often attributed to defects in cell cycle regulatory genes can be generated by compromising the function of CTNNA1.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Reconsitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blot, 0.1-0.5μg/ml, Human, Rat
Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, Mouse, Rat, By Heat
Immunohistochemistry (Frozen Section), 0.5-1μg/ml, Rat
Immunocytochemistry/Immunofluorescence, 2μg/ml, Human
Flow Cytometry, 1-3μg/1x106 cells, Human

Validation Images & Assay Conditions

Gene/Protein Information For CTNNA1 (Source: Uniprot.org, NCBI)

Gene Name

CTNNA1

Full Name

Catenin alpha-1

Weight

100.071kDa

Superfamily

vinculin/alpha-catenin family

Alternative Names

Alpha E-catenin; alpha-catenin; alpha-E-catenin; alphaE-catenin; cadherin-associated protein; CAP102; catenin (cadherin-associated protein), alpha 1 (102kD); catenin (cadherin-associated protein), alpha 1, 102kDa; catenin alpha-1; FLJ36832; FLJ52416; Renal carcinoma antigen NY-REN-13 CTNNA1 CAP102, MDPT2 catenin alpha 1 catenin alpha-1|alpha-E-catenin|catenin (cadherin-associated protein), alpha 1, 102kDa|epididymis secretory sperm binding protein|renal carcinoma antigen NY-REN-13

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on CTNNA1, check out the CTNNA1 Infographic

CTNNA1 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for CTNNA1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

Hello CJ!

PB9137 has been cited in 2 publications:

*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.

Prognostic and clinicopathological features of E-cadherin, ?-catenin, ?-catenin, ?-catenin and cyclin D1 expression in human esophageal squamous cell carcinoma

TALENs-directed?knockout?of the?full-length?transcription?factor?Nrf1? that?represses?malignantbehaviour?of?human?hepatocellular?carcinoma?(HepG2)?cells

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2 Customer Q&As for Anti-alpha 1 Catenin/CTNNA1 Antibody Picoband™

Question

Will PB9137 and M01617 react with CTNNA2 and its isoforms?

Verified customer

Asked: 2019-11-20

Answer

Our lab hasn't experimentally validate the Anti-Alpha 1 Catenin/CTNNA1 Antibody Picoband™ (PB9137) and Anti-Catenin Alpha 1 CTNNA1 Rabbit Monoclonal Antibody (M01617) cross reactivity with CTNNA2 and its isoforms. Sequence homology with CTNNA2 and its isoforms is low.

Boster Scientific Support

Answered: 2019-11-20

Question

We are currently using anti-alpha 1 Catenin/CTNNA1 antibody PB9137 for mouse tissue, and we are content with the Flow Cytometry results. The species of reactivity given in the datasheet says human, mouse, rat. Is it true that the antibody can work on monkey tissues as well?

B. Parker

Verified customer

Asked: 2013-05-22

Answer

The anti-alpha 1 Catenin/CTNNA1 antibody (PB9137) has not been tested for cross reactivity specifically with monkey tissues, but there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in monkey you can get your next antibody for free. Please contact me if I can help you with anything.

Boster Scientific Support

Answered: 2013-05-22

Order DetailsPrice
PB9137

100μg

$370
PB9137-10ug

10μg sample (liquid)

$99
PB9137-Biotin

100 μg Biotin conjugated

$570
PB9137-Cy3

100 μg Cy3 conjugated

$570
PB9137-Dylight488

100 μg Dylight488 conjugated

$570
PB9137-Dylight550

100 μg Dylight550 conjugated

$570
PB9137-Dylight594

100 μg Dylight594 conjugated

$570
PB9137-FITC

100 μg FITC conjugated

$570
PB9137-HRP

100 μg HRP conjugated

$570
PB9137-APC

100 μg APC conjugated

$670
PB9137-PE

100 μg PE conjugated

$670
PB9137-carrier-free

Carrier Free

$370

More conjugates/formats

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PB9137
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$370.00

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