Anti-Cyclin D3 Ccnd3 Antibody

Cyclin D3 antibody

Boster Bio Anti-Cyclin D3 Ccnd3 Antibody (Catalog # A01744). Tested in ELISA, Flow Cytometry, IHC, IP applications. This antibody reacts with Human, Mouse.

Product Info Summary

SKU: A01744
Size: 100ug
Reactive Species: Human, Mouse
Host: Rabbit
Application: ELISA, Flow Cytometry, IP, IHC

Product Name

Anti-Cyclin D3 Ccnd3 Antibody

View all Cyclin D3 Antibodies

SKU/Catalog Number

A01744

Size

100ug

Form

Liquid (sterile filtered)

Description

Boster Bio Anti-Cyclin D3 Ccnd3 Antibody (Catalog # A01744). Tested in ELISA, Flow Cytometry, IHC, IP applications. This antibody reacts with Human, Mouse.

Storage & Handling

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.

Cite This Product

Anti-Cyclin D3 Ccnd3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01744)

Host

Rabbit

Contents

0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2, 0.01% (w/v) Sodium Azide

Clonality

Polyclonal

Isotype

IgG

Immunogen

This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to the C-terminal domain of mouse Cyclin D3 protein.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A01744 is reactive to CCND3 in Human, Mouse

Applications

A01744 is guaranteed for ELISA, Flow Cytometry, IP, IHC Boster Guarantee

Observed Molecular Weight

42 kDa

Calculated molecular weight

32.52kDa

Background of Cyclin D3

Anti-Cyclin D3 antibody was designed, produced, and validated as part of the Joy Cappel Young Investigator Award (JCYIA). Cyclin D3 belongs to a highly conserved cyclin family, whose members are the ultimate recipients of oncogenic signals. Cyclin D3 is a key component of the cell cycle progression machinery and induces progression through the G1 phase of the cell cycle. Cyclin D3 is expressed in nearly all proliferating cells, and shows the most broad expression pattern of all three D-type (D1-D3) cyclins. Cyclin D3 is encoded from the 6p21 chromosome region and the protein is predominantly localized in the nucleus. Once induced, cyclin D3 binds and activates its associated cyclin-dependent kinases CDK4 and CDK6. Amplification of the cyclin D3 gene and overexpression of cyclin D3 protein is seen in several human cancers. A large number of human malignancies contain lesions in pathways impacting on cyclin D3. Abnormal expression of Cyclin D3 is believed to be a driving force in several human cancers. A possible role for cyclin D3 in the malignancies of the lymphoid system is suggested by the observations that cyclin D3 gene is rearranged in several neoplastic diseases such as diffuse large B cell lymphomas or multiple myelomas. Anti-Cyclin D3 is ideal for researchers interested in Cancer Research and Immunology research.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Reconsitution

Restore with deionized water (or equivalent) for reconstitution volume of 100 µL

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

ELISA: 1:1000 - 1:5000
Flow Cytometry: 4µg/mL
IHC: 4µg/mL
IP: 5µg/mL
WB: 1.0 ug/ml

Validation Images & Assay Conditions

Gene/Protein Information For CCND3 (Source: Uniprot.org, NCBI)

Gene Name

CCND3

Full Name

G1/S-specific cyclin-D3

Weight

32.52kDa

Superfamily

cyclin family

Alternative Names

CCND3; Cyclin D3; D3-type cyclin; G1/S-specific cyclin D3; G1/S-specific cyclin-D3 CCND3 cyclin D3 G1/S-specific cyclin-D3|D3-type cyclin

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on CCND3, check out the CCND3 Infographic

CCND3 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for CCND3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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Order DetailsPrice
A01744

100 μg

$599

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