Anti-CYP7A1 Monoclonal Antibody

CYP7A1 antibody

Boster Bio Anti-CYP7A1 Monoclonal Antibody catalog # M01601. Tested in WB applications. This antibody reacts with Human.

Product Info Summary

SKU: M01601
Size: 100ul
Reactive Species: Human
Host: Mouse
Application: WB

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Product Name

Anti-CYP7A1 Monoclonal Antibody

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SKU/Catalog Number

M01601

Size

100ul

Form

Liquid

Description

Boster Bio Anti-CYP7A1 Monoclonal Antibody catalog # M01601. Tested in WB applications. This antibody reacts with Human.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-CYP7A1 Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M01601)

Host

Mouse

Contents

Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.

Clonality

Monoclonal

Clone Number

4D2

Isotype

IgG

Immunogen

Purified recombinant human CYP7A1 (C-terminal) protein fragments expressed in E.coli.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

M01601 is reactive to CYP7A1 in Human

Applications

M01601 is guaranteed for WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

57.661kDa

Background of CYP7A1

Bin1 is a conserved member of the BAR family of genes that have been implicated in diverse cellular processes including endocytosis, actin organization, programmed cell death, stress responses, and transcriptional control. The first mammalian BAR protein to be discovered, Amphiphysin I (AmphI), was identified in an immunoscreen for proteins associated with the plasma membranes of synaptic neurons, functions in the control of clathrin-dependent synaptic vesicle endocytosis. The mammalian Bin1 gene was first identified in a two hybrid screen for polypeptides that bind to the N-terminal Myc box 1 (MB1) portion of the c-Myc oncoprotein. Bin1 is similar to AmphI in overall structure, with an N-terminal BAR domain and a C-terminal SH3 domain. However, the Bin1 gene is more complex than the AmphI gene, encoding at least seven different splice variants that differ widely in subcellular localization, tissue distribution, and ascribed functions. Alternate splicing of the Bin1 gene results in ten transcript variants encoding different isoform. Bin1 is expressed ubiquitously in mammalian cells. Certain splice variants of Bin1 are expressed in the neurons, muscle cells or tumor cells. Bin1 may act as a cancer suppressor and inhibits malignant cell transformation. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Bin1 has also been implicated in Alzheimer disease and cardiac disease. Defects in Bin1 are the cause of centronuclear myopathy autosomal recessive; also known as autosomal recessive myotubular myopathy.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB 1:1000-1:2000

Validation Images & Assay Conditions

Gene/Protein Information For CYP7A1 (Source: Uniprot.org, NCBI)

Gene Name

CYP7A1

Full Name

Cytochrome P450 7A1

Weight

57.661kDa

Superfamily

cytochrome P450 family

Alternative Names

Cholesterol 7-alpha-hydroxylase; cholesterol 7-alpha-monooxygenase; CP7A; CYP7; CYP7A1; CYP7MGC126826; CYPVII; Cytochrome P450 7A1; cytochrome P450, family 7, subfamily A, polypeptide 1; cytochrome P450, subfamily VIIA (cholesterol 7 alpha-monooxygenase); cytochrome P450, subfamily VIIA polypeptide 1; EC 1.14.13; EC 1.14.13.17; MGC138389; polypeptide 1 CYP7A1 CP7A, CYP7, CYPVII cytochrome P450 family 7 subfamily A member 1 cytochrome P450 7A1|24-hydroxycholesterol 7-alpha-hydroxylase|cholesterol 7-alpha-hydroxylase|cholesterol 7-alpha-monooxygenase|cholesterol 7alpha-hydroxylase|cytochrome P450, family 7, subfamily A, polypeptide 1|cytochrome P450, subfamily VIIA polypeptide 1

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on CYP7A1, check out the CYP7A1 Infographic

CYP7A1 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for CYP7A1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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1 Customer Q&As for Anti-CYP7A1 Monoclonal Antibody

Question

What buffer is in M01601? Does it contain BSA?

Verified customer

Asked: 2021-02-08

Answer

For the Anti-CYP7A1 Monoclonal Antibody, purified mouse monoclonal in a buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 2% BSA,50% glycerol.

Boster Scientific Support

Answered: 2021-02-10

Order DetailsPrice
M01601-100ul

100ul

$380

Free Secondary Antibody

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Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$380.00

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