Anti-ERI1/Hexo Antibody

HEXO antibody

Boster Bio Anti-ERI1/Hexo Antibody (Catalog # A07945). Tested in WB applications. This antibody reacts with Human.

Product Info Summary

SKU: A07945
Size: 100 µl
Reactive Species: Human
Host: Rabbit
Application: WB

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Product Name

Anti-ERI1/Hexo Antibody

View all HEXO Antibodies

SKU/Catalog Number

A07945

Size

100 µl

Form

Liquid

Description

Boster Bio Anti-ERI1/Hexo Antibody (Catalog # A07945). Tested in WB applications. This antibody reacts with Human.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-ERI1/Hexo Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A07945)

Host

Rabbit

Contents

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from internal of human ERI1.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A07945 is reactive to Eri1 in Human

Applications

A07945 is guaranteed for WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

39.493kDa

Background of HEXO

RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.

Dominski Z., Mol. Cell 12:295-305(2003).
Ota T., Nat. Genet. 36:40-45(2004).
Bechtel S., BMC Genomics 8:399-399(2007)

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blotting: 1:500~1:3000

Validation Images & Assay Conditions

Gene/Protein Information For Eri1 (Source: Uniprot.org, NCBI)

Gene Name

Eri1

Full Name

3'-5' exoribonuclease 1

Weight

39.493kDa

Alternative Names

3' exoribonuclease; 3'-5' exonuclease ERI1; 3'EXO; 3'HEXO; EC 3.1; enhanced RNAi three prime mRNA exonuclease homolog 1; Eri-1 homolog; exoribonuclease 1; HEXO; histone mRNA 3' end-specific exonuclease; Histone mRNA 3'-end-specific exoribonuclease; Histone mRNA 3'-exonuclease 1; MGC35395; Protein 3'hExo; THEX1; three prime histone mRNA exonuclease 1,3'-5' exoribonuclease 1; three prime mRNA exonuclease 1 Eri1|3hexo, 3110010F15Rik, Er, Thex1, eri-1|exoribonuclease 1|3-5 exoribonuclease 1|3-5 exonuclease ERI1|enhanced RNAi protein 1|eri-1 homolog|histone mRNA 3 end-specific exonuclease|histone mRNA 3-exonuclease 1|three prime histone mRNA exonuclease 1

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on Eri1, check out the Eri1 Infographic

Eri1 infographic

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In this infographic, you will see the following information for Eri1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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4 Customer Q&As for Anti-ERI1/Hexo Antibody

Question

Do you have a BSA free version of anti-ERI1/Hexo antibody A07945 available?

S. Johnson

Verified customer

Asked: 2020-01-15

Answer

Thanks for your recent telephone inquiry. I can confirm that some lots of this anti-ERI1/Hexo antibody A07945 are BSA free. For now, these lots are available and we can make a BSA free formula for you free of charge. It will take 3 extra days to prepare. If you require this antibody BSA free again in future, please do not hesitate to contact me and I will be pleased to check which lots we have in stock that are BSA free.

Boster Scientific Support

Answered: 2020-01-15

Question

I appreciate helping with my inquiry over the phone. Here are the WB image, lot number and protocol we used for secondary oocyte using anti-ERI1/Hexo antibody A07945. Let me know if you need anything else.

Verified Customer

Verified customer

Asked: 2019-08-14

Answer

Thanks for the data. You have provided everything we needed. Our lab team are working to resolve your inquiry as quickly as possible, and we appreciate your patience and understanding! Please let me know if there is anything you need in the meantime.

Boster Scientific Support

Answered: 2019-08-14

Question

Our lab want to know about to test anti-ERI1/Hexo antibody A07945 on human secondary oocyte for research purposes, then I may be interested in using anti-ERI1/Hexo antibody A07945 for diagnostic purposes as well. Is the antibody suitable for diagnostic purposes?

Verified Customer

Verified customer

Asked: 2019-05-29

Answer

The products we sell, including anti-ERI1/Hexo antibody A07945, are only intended for research use. They would not be suitable for use in diagnostic work. If you have the means to develop a product into diagnostic use, and are interested in collaborating with us and develop our product into an IVD product, please contact us for more discussions.

Boster Scientific Support

Answered: 2019-05-29

Question

We are currently using anti-ERI1/Hexo antibody A07945 for human tissue, and we are well pleased with the WB results. The species of reactivity given in the datasheet says human. Is it likely that the antibody can work on primate tissues as well?

A. Edwards

Verified customer

Asked: 2016-11-04

Answer

The anti-ERI1/Hexo antibody (A07945) has not been tested for cross reactivity specifically with primate tissues, though there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in primate you can get your next antibody for free. Please contact me if I can help you with anything.

Boster Scientific Support

Answered: 2016-11-04

Order DetailsPrice
A07945-100uL

100uL

$360

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