Anti-GITRL TNFSF18 Antibody

GITR Ligand/TNFSF18 antibody

Boster Bio Anti-GITRL TNFSF18 Antibody (Catalog # A04408). Tested in ELISA, WB, ICC applications. This antibody reacts with Human, Mouse.

Product Info Summary

SKU: A04408
Size: 0.1 mg
Reactive Species: Human, Mouse
Host: Rabbit
Application: ELISA, ICC, WB

Product Name

Anti-GITRL TNFSF18 Antibody

View all GITR Ligand/TNFSF18 Antibodies

SKU/Catalog Number

A04408

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-GITRL TNFSF18 Antibody (Catalog # A04408). Tested in ELISA, WB, ICC applications. This antibody reacts with Human, Mouse.

Storage & Handling

GITRL antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-GITRL TNFSF18 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A04408)

Host

Rabbit

Contents

GITRL Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Clone Number

SK7

Isotype

IgG

Immunogen

GITRL antibody was raised against purified recombinant human GITR ligand.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

This BICD2 antibody will not cross-react with BICD1.

Reactive Species

A04408 is reactive to TNFSF18 in Human, Mouse

Applications

A04408 is guaranteed for ELISA, ICC, WB Boster Guarantee

Observed Molecular Weight

68 kDa

Calculated molecular weight

22.724kDa

Background of GITR Ligand/TNFSF18

The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate numerous biological functions including cell proliferation, differentiation, and survival through regulating the activation of the transcription factor NF-κB and various mitogen-activated protein kinases. The glucocorticoid-induced tumor necrosis factor receptor (GITR) is an emerging member of this family that is expressed on CD4+ CD25+ regulatory T cells and appears to have crucial immune regulation functions. Its ligand GITRL is expressed in endothelial and antigen-presenting cells and can activate NF-κB, induce both pro- and anti-apoptotic effects, inhibit the suppressive activity of regulatory T cells, and co-stimulate responder T cells through GITR. Dominant negative forms of NIK and TRAF2 expressed in transfected 293 cells substantially inhibited NF-κB activation, suggesting that the GITRL-GITR pathway involves both NIK and TRAF2.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

GITRL antibody can be used for the detection of GITRL by Western blot at 1 μg/mL. Antibody can also be used for immunocytochemistry starting at 10 μg/mL.
Antibody validated: Immunocytochemistry in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

Gene/Protein Information For TNFSF18 (Source: Uniprot.org, NCBI)

Gene Name

TNFSF18

Full Name

Tumor necrosis factor ligand superfamily member 18

Weight

22.724kDa

Superfamily

tumor necrosis factor family

Alternative Names

Activation-inducible TNF-related ligand; AITRL; AITRLMGC138237; GITR Ligand; GITRL; GITRLglucocorticoid-induced TNFR-related protein ligand; Glucocorticoid-induced TNF-related ligand; hGITRLGITR ligand; TL6AITR ligand; TNFSF18; tumor necrosis factor (ligand) superfamily, member 18; tumor necrosis factor ligand superfamily member 18 TNFSF18 AITRL, GITRL, TL6, TNLG2A, hGITRL TNF superfamily member 18 tumor necrosis factor ligand superfamily member 18|AITR ligand|GITR ligand|activation-inducible TNF-related ligand|glucocorticoid-induced TNF-related ligand|glucocorticoid-induced TNFR-related protein ligand|tumor necrosis factor (ligand) superfamily, member 18|tumor necrosis factor ligand 2A|tumor necrosis factor superfamily member 18

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on TNFSF18, check out the TNFSF18 Infographic

TNFSF18 infographic

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In this infographic, you will see the following information for TNFSF18: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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Order DetailsPrice
A04408-0.1 mg

0.1 mg

$449

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*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$449.00

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