Anti-Glutamate Receptor 1/GRIA1 Antibody
Rabbit IgG polyclonal antibody for Glutamate receptor 1(GRIA1) detection. Tested with WB in Human;Mouse;Rat. Cited in 2 publication(s).
Anti-Glutamate Receptor 1/GRIA1 Antibody Info At A Glance
|Reactivity:||Human, Mouse, Rat|
|Product Name||Anti-Glutamate Receptor 1/GRIA1 Antibody
See all GluR1 primary antibodies, ELISA kits and proteins
|Storage & Handling||At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.|
|Description||Polyclonal antibody for GluR1/GRIA1 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: WB. Reactive species: Human. GluR1/GRIA1 information: Molecular Weight: 101506 MW; Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density . Cell projection, dendrite . Cell projection, dendritic spine . Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression; Tissue Specificity: Widely expressed in brain.|
|Cite This Product||Anti-Glutamate Receptor 1/GRIA1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1587)|
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|Anti-Glutamate Receptor 1/GRIA1 Antibody may replace the following items: sc 101688|sc 12624|sc 12624 R|sc 13152|sc 135698|sc 135699|sc 16313|sc 16313 R|sc 16314|sc 16314 R|sc 26472|sc 28799|sc 33612|sc 55509|sc 7609.|
|Reactivity/Species||Human, Mouse, Rat|
*This antibody is predicted to react with the above species based on antigen sequence similarities. Our Boster Guarantee covers the use of this product with the above species.
*Our Boster Guarantee covers the use of this product in the above tested applications.
*Innovating Scientists reward: if you test this antibody on a species or application not listed above and share with us your results, we will provide you a full credit to purchase Boster products.
|Related Products||Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.
*Blocking peptide can be purchased at $50. Contact us for more information.
**Boster also offers various secondary antibodies for Immunoflourescecne and IHC. Take advantage of the buy 1 primary antibody get 1 secondary antibody for free promotion all year round.
|Immunogen||A synthetic peptide corresponding to a sequence at the C-terminus of human GRIA1 (881-895aa HDFPKSMQSIPCMSH), different from the related rat and mouse sequences by one amino acid.|
|Cross Reactivity||No cross reactivity with other proteins|
Gene/Protein Basic Information For GRIA1 (Source: Uniprot.org, NCBI)
|NCBI Gene Id||2890|
|Species Of This Entry||Human|
|Protein Name||Glutamate receptor 1|
|Superfamily||glutamate-gated ion channel (TC 1.A.10.1) family|
|Alternative Names||GluR1|AMPA 1; AMPA-selective glutamate receptor 1; GluA1; GLUH1; GluR1; gluR-1; GLUR1gluR-A; GLURA; GluR-A; gluR-K1; glutamate receptor 1; Glutamate receptor ionotropic, AMPA 1; glutamate receptor, ionotropic, AMPA 1; GRIA1; HBGR1; MGC133252|
|Post Tranlational Modifications||Phosphorylation; Acetylation; Methylation|
|Subcellular Localization||Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic density membrane; Multi-pass membrane protein. Cell projection, dendrite. Cell projection, dendritic spine. Early endosome membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression. Colocalizes with PDLIM4 in early endosomes. Displays a somatodendritic localizatio|
|Gene Location||5q33.2, on Chromasome 5, gene sequence: NC_000005.10 (153490524..153813873)|
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
Ontology For GRIA1 (Source: Uniprot.org, NCBI)
|Protein Function||Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.|
|Tissue Specificity||Widely expressed in brain.|
|Related Diseases||Schizophrenia; Depressive Disorder; Malnutrition; Nervousness; Bipolar Disorder; Psychotic Disorders; Major Depressive Disorder; Malignant Neoplasms; Neoplasms; Anxiety Disorders; Pituitary Diseases; Sudden Cardiac Death; Stress, Psychological; Dysequilibrium Syndrome; Sudden Cardiac Arrest; Ventricular Fibrillation|
|Related Pathways||Synaptic Transmission; Pathogenesis; Transport; Cell Adhesion; Aging; Brain Development; Fertilization; Hypersensitivity; Myelination; Regulation Of Histone Acetylation; Swimming; Stem Cell Proliferation; Histone Acetylation; Histone Lysine Methylation; Cognition; Histone Methylation; Hormone Secretion; Cell Proliferation; Gastrulation; Transmembrane Transport|
|Background||GLUR1, Glutamate receptor 1, is a protein that in humans is encoded by the GLUR1 gene. The sequence of GLUR1 was predicted to encode a 907-amino acid protein that had 97% identity to one of the rodent kainate receptor subunits. GLUR1 mRNA is widely expressed in human brain. Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The GRIA1 belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate(AMPA) receptors. Each of the members(GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing. The receptor subunits encoded by each isoform vary in their signal transduction properties. The isoform presented here is the flop isoform. In situ hybridization experiments showed that human GRIA1 mRNA is present in granule and pyramidal cells in the hippocampal formation.|
|Scientific References||PMID: 1652753 by Puckett C., et al. Molecular cloning and chromosomal localization of one of the human glutamate receptor genes.|
PMID: 1320959 by Potier M.-C., et al. The human glutamate receptor cDNA GluR1: cloning, sequencing, expression and localization to chromosome 5.
Our Boster Quality Guarantee for Anti-Glutamate Receptor 1/GRIA1 Antibody covers its use in the following applications.Western blot, 0.1-0.5μg/ml, Rat, Human, Mouse
*The recommended dilution ratios/concentrations are for reference only and optimal dilutions/concentrations should be determined by the end user.
All lanes: Anti GRIA1 (PA1587) at 0.5ug/ml
WB: Rat Brain Tissue Lysate at 50ug
Predicted bind size: 101KD
Observed bind size: 101KD
Boster provides comprehensive technical information for WB, IHC/IF/ICC, Flow Cytometry sample preparation protocols, assay protocols, troubleshooting tips and assay optimization tips.
- Western Blottting Resource Center
- Immunohistochemistry Resource Center
- Flow Cytometry Technical Resource Center
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Total number of citations: 2
|Zhong C, Han Y, Qiu J, Lu L, Chen Y, Chen J, Hei R, Mi W. Int J Pediatr Otorhinolaryngol. 2010 Feb;74(2):192-7. Doi: 10.1016/J.Ijporl.2009.11.009. Epub 2009 Dec 5. A Comparison Of The Proliferative Capacity And Ultrastructure Of Proliferative Cell...||PubMed ID 19963281|
|Loss of the golgin GM130 causes Golgi disruption, Purkinje neuron loss, and ataxia in mice||PubMed ID 28028212|
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