Product Info Summary
SKU: | A01913 |
---|---|
Size: | 100ug |
Reactive Species: | Human, Mouse, Rat, Primate |
Host: | Rabbit |
Application: | ELISA, WB |
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Product info
Product Name
Anti-HDAC-7 (N-terminus) Antibody
SKU/Catalog Number
A01913
Size
100ug
Form
Liquid (sterile filtered)
Description
Boster Bio Anti-HDAC-7 (N-terminus) Antibody (Catalog # A01913). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat, Primate.
Storage & Handling
Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is six (6) months from date of opening.
Cite This Product
Anti-HDAC-7 (N-terminus) Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01913)
Host
Rabbit
Contents
0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2, 0.01% (w/v) Sodium Azide
Clonality
Polyclonal
Isotype
IgG
Immunogen
HDAC7 affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to the N terminal region of human HDAC7.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
No cross reactivity with other proteins.
Reactive Species
A01913 is reactive to HDAC7 in Human, Mouse, Rat, Primate
Applications
A01913 is guaranteed for ELISA, WB Boster Guarantee
Observed Molecular Weight
42 kDa
Calculated molecular weight
102.927kDa
Background of HDAC7
HDAC7 is a member of the class II mammalian histone deacetylases, which plays an important role in modulating the eukaryotic chromatin structure. Human HDAC7 is composed of 912 amino acid residues. Although HDAC7 is localized mostly to the cell nucleus, it is also found in the cytoplasm, suggesting nucleo-cytoplasmic shuttling. The histone deacetylase activity of HDAC7 maps to a carboxy-terminal domain and is dependent on interaction with class I HDACs in the nucleus. It is an active component of different transcriptional corepressor complexes that can be recruited to specific promoter regions via interactions with a growing number of sequence specific transcriptional factors. HDAC7 catalyzes removal of acetyl-groups from acetyl-lysines of histones and promotes compaction of chromatin in these regions, leading to the inhibition of gene transcription. Anti-HDAC7 antibodies are ideal for researches interested in Breast Cancer, Cancer, Cell Cycle and Replication, Chromatin Research, Epigenetics, and Histone Deacetylases research.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
ELISA: 1:20,000 - 1:60,000
IHC: 1:100-1:500
IF Microscopy: 1:100-1:500
WB: 1 µg/ml
Validation Images & Assay Conditions
Click image to see more details
Western blot analysis of HDAC-7 expression in mouse brain homogenate (lane 1) and mouse brain homogenate blocked with peptide (lane 2). HDAC-7 at 103KD was detected using rabbit anti-HDAC-7 Antigen Affinity purified polyclonal antibody (Catalog # A01913) at 1 μg/mL. Other band(s): HDAC7 isoforms ~70 and 40kDa. The blot was developed using chemiluminescence (ECL) method (Catalog # EK1002).
Protein Target Info & Infographic
Gene/Protein Information For HDAC7 (Source: Uniprot.org, NCBI)
Gene Name
HDAC7
Full Name
Histone deacetylase 7
Weight
102.927kDa
Superfamily
histone deacetylase family
Alternative Names
DKFZP586J0917; EC 3.5.1.98; HD7; HD7A; HDAC7AFLJ99588; histone deacetylase 7; Histone deacetylase 7ADKFZp586J0917 HDAC7 HD7, HD7AA, HDAC7 histone deacetylase 7 histone deacetylase 7|histone deacetylase 7A
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on HDAC7, check out the HDAC7 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for HDAC7: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-HDAC-7 (N-terminus) Antibody (A01913)
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No publications found for A01913
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