Anti-HER-2 / c-erbB-2 / neu / CD340 Monoclonal Antibody

Boster Bio Anti-HER-2 / c-erbB-2 / neu / CD340 Monoclonal Antibody catalog # M00010. Tested in IHC applications. This antibody reacts with Human. Cited in 3 publication(s).

Product Info Summary

SKU: M00010
Size: 100ug/vial
Reactive Species: Human
Host: Mouse
Application: IHC

Product Name

Anti-HER-2 / c-erbB-2 / neu / CD340 Monoclonal Antibody

See all ErbB2/Her2 products

SKU/Catalog Number

M00010

Size

100ug/vial

Form

Liquid

Description

Boster Bio Anti-HER-2 / c-erbB-2 / neu / CD340 Monoclonal Antibody catalog # M00010. Tested in IHC applications. This antibody reacts with Human.

Storage & Handling

Cite This Product

Anti-HER-2 / c-erbB-2 / neu / CD340 Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M00010)

Host

Mouse

Contents

Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Clonality

Monoclonal

Clone Number

ERB2/776

Immunogen

Recombinant intracellular domain of human HER-2 protein

Reactive Species

M00010 is reactive to ERBB2 in Human

Applications

M00010 is guaranteed for IHC Boster Guarantee

*Blocking peptide can be purchased at $150. Contact us for more information.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence and ELISA with known positive and negative samples to ensure specificity and high affinity.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. Actual working concentration varies and should be decided by the user.

Immunohistology (Formalin-fixed ) (0.5-1ug/ml for 30 min at Room Temp)
Immunofluorescence (0.5-1ug/ml)

Validation Images & Assay Conditions

Gene/Protein Information For ERBB2 (Source: Uniprot.Org, NCBI)

Uniprot ID

P04626

Gene ID

2064

Gene Name

ERBB2

Full Name

Receptor tyrosine-protein kinase erbB-2

Weight

137.91kDa

Superfamily

protein kinase superfamily

Alternative Names

CD340 antigen; CD340; c-erb B2/neu protein; EC 2.7.10; EGFR2; ErbB2; HER2; HER-2; HER2EC 2.7.10.1; herstatin; Metastatic lymph node gene 19 protein; MLN 19; MLN19; Neu Oncogene; NEUHER-2/neu; neuroblastoma/glioblastoma derived oncogene homolog; NGL; NGLTKR1; p185erbB2; Proto-oncogene c-ErbB-2; Proto-oncogene Neu; receptor tyrosine-protein kinase erbB-2; TKR1; Tyrosine kinase-type cell surface receptor HER2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2(neuro/glioblastoma derived oncogene homolog); v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastomade ERBB2 CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1 erb-b2 receptor tyrosine kinase 2 receptor tyrosine-protein kinase erbB-2|c-erb B2/neu protein|herstatin|human epidermal growth factor receptor 2|metastatic lymph node gene 19 protein|neuro/glioblastoma derived oncogene homolog|neuroblastoma/glioblastoma derived oncogene homolog|proto-oncogene Neu|proto-oncogene c-ErbB-2|tyrosine kinase-type cell surface receptor HER2|v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2|v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2|v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog

*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".

For more info on ERBB2, check out the ERBB2 Infographic

ERBB2 infographic

We have 30,000+ of these available, one for each gene! check them out.

In this infographic you will see the following information for ERBB2: database IDs, super-family, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact us [email protected]

M00010 has been cited in 3 publications:

*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.

Lapatinib-incorporated lipoprotein-like nanoparticles: preparation and a proposed breast cancer-targeting mechanism

Tong ZJ, Shi NY, Zhang ZJ, Yuan XD, Hong XM. Biosci Rep. 2017 Aug 2;37(4). pii: BSR20170121. doi: 10.1042/BSR20170121. Print 2017 Aug 31. Expression and prognostic value of HER-2/neu in primary breast cancer with sentinel lymph node metastasis

Tao L, Suhua C, Juanjuan C, Zongzhi Y, Juan X, Dandan Z. Virol J. 2011 Mar 11;8:114. Doi: 10.1186/1743-422X-8-114. In Vitro Study On Human Cytomegalovirus Affecting Early Pregnancy Villous Evt'S Invasion Function.

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3 Customer Q&As for Anti-HER-2 / c-erbB-2 / neu / CD340 Monoclonal Antibody

Question

We have seen staining in human cervix carcinoma erythroleukemia. What should we do? Is anti-HER-2 / c-erbB-2 / neu / CD340 Monoclonal antibody supposed to stain cervix carcinoma erythroleukemia positively?

Verified Customer

Verified customer

Asked: 2020-02-18

Answer

From literature cervix carcinoma erythroleukemia does express ERBB2. From Uniprot.org, ERBB2 is expressed in esophagus mucosa, brain, fetal brain, mammary carcinoma, cervix carcinoma, cervix carcinoma erythroleukemia, liver, among other tissues. Regarding which tissues have ERBB2 expression, here are a few articles citing expression in various tissues:
Brain, Pubmed ID: 15489334
Cervix carcinoma, Pubmed ID: 17081983, 18669648, 18691976, 20068231
Cervix carcinoma, and Erythroleukemia, Pubmed ID: 23186163
Fetal brain, Pubmed ID: 24722188
Liver, Pubmed ID: 24275569
Mammary carcinoma, Pubmed ID: 2992089

Boster Scientific Support

Answered: 2020-02-18

Question

We are currently using anti-HER-2 / c-erbB-2 / neu / CD340 Monoclonal antibody M00010 for human tissue, and we are well pleased with the IHC results. The species of reactivity given in the datasheet says human. Is it likely that the antibody can work on feline tissues as well?

A. Walker

Verified customer

Asked: 2019-05-30

Answer

The anti-HER-2 / c-erbB-2 / neu / CD340 Monoclonal antibody (M00010) has not been validated for cross reactivity specifically with feline tissues, though there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in feline you can get your next antibody for free. Please contact me if I can help you with anything.

Boster Scientific Support

Answered: 2019-05-30

Question

My boss were content with the WB result of your anti-HER-2 / c-erbB-2 / neu / CD340 Monoclonal antibody. However we have seen positive staining in fetal brain isoform 1: cell membrane using this antibody. Is that expected? Could you tell me where is ERBB2 supposed to be expressed?

E. Walker

Verified customer

Asked: 2016-09-15

Answer

According to literature, fetal brain does express ERBB2. Generally ERBB2 expresses in isoform 1: cell membrane, isoform 2: cytoplasm. nucleus., isoform 3: cytoplasm. nucleus. Regarding which tissues have ERBB2 expression, here are a few articles citing expression in various tissues:
Brain, Pubmed ID: 15489334
Cervix carcinoma, Pubmed ID: 17081983, 18669648, 18691976, 20068231
Cervix carcinoma, and Erythroleukemia, Pubmed ID: 23186163
Fetal brain, Pubmed ID: 24722188
Liver, Pubmed ID: 24275569
Mammary carcinoma, Pubmed ID: 2992089

Boster Scientific Support

Answered: 2016-09-15

Size

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M00010
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*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$399.00

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