Anti-IP3 receptor/ITPR1 Antibody Picoband™

IP3R1 antibody

Boster Bio Anti-IP3 receptor/ITPR1 Antibody Picoband™ catalog # PB9225. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. Cited in 3 publication(s).

Product Info Summary

SKU: PB9225
Size: 100 μg/vial
Reactive Species: Human, Mouse, Rat
Host: Rabbit
Application: Flow Cytometry, IF, IHC, ICC, WB

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Product Name

Anti-IP3 receptor/ITPR1 Antibody Picoband™

View all IP3R1 Antibodies

SKU/Catalog Number

PB9225

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-IP3 receptor/ITPR1 Antibody Picoband™ catalog # PB9225. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-IP3 receptor/ITPR1 Antibody Picoband™ (Boster Biological Technology, Pleasanton CA, USA, Catalog # PB9225)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

E.coli-derived human IP3 receptor recombinant protein (Position: A2411-A2758). Human IP3 receptor shares 98% and 97% amino acid (aa) sequences identity with mouse and rat IP3 receptor, respectively.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

PB9225 is reactive to ITPR1 in Human, Mouse, Rat

Applications

PB9225 is guaranteed for Flow Cytometry, IF, IHC, ICC, WB Boster Guarantee

Observed Molecular Weight

290 kDa

Calculated molecular weight

313.929kDa

Background of IP3R1

Inositol 1,4,5-trisphosphate receptor type 1, also known as IP3R or IP3R1, is a protein that in humans is encoded by the ITPR1 gene. It is mapped to 3p26.1. The product of the ITPR1 gene is predominantly enriched in cerebellar Purkinje cells but is also concentrated in neurons in the hippocampal CA1 region, caudate-putamen, and cerebral cortex. The ITPR1 gene encodes the inositol 1,4,5-triphosphate (IP3) receptor, an intracellular IP3-gated calcium channel that modulates intracellular calcium signaling. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in ITPR1 cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Reconsitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blot, 0.1-0.5μg/ml, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, Mouse, Rat, By Heat
Immunocytochemistry/Immunofluorescence, 2μg/ml, Human
Flow Cytometry, 1-3μg/1x106 cells, Human

Validation Images & Assay Conditions

Gene/Protein Information For ITPR1 (Source: Uniprot.org, NCBI)

Gene Name

ITPR1

Full Name

Inositol 1,4,5-trisphosphate receptor type 1

Weight

313.929kDa

Superfamily

InsP3 receptor family

Alternative Names

DKFZp313E1334; DKFZp313N1434; inositol 14,5-triphosphate receptor, type 1; inositol 14,5-trisphosphate receptor type 1; INSP3R1; IP3 receptor isoform 1; IP3 receptor; IP3R 1; IP3R; IP3R1; SCA15; SCA16; spinocerebellar ataxia 15; spinocerebellar ataxia 16; Type 1 inositol 14,5-trisphosphate receptor; Type 1 InsP3 receptor ITPR1 ACV, CLA4, INSP3R1, IP3R, IP3R1, PPP1R94, SCA15, SCA16, SCA29 inositol 1,4,5-trisphosphate receptor type 1 inositol 1,4,5-trisphosphate receptor type 1|IP3 receptor|IP3R 1|inositol 1,4,5-triphosphate receptor, type 1|protein phosphatase 1, regulatory subunit 94|type 1 InsP3 receptor|type 1 inositol 1,4,5-trisphosphate receptor

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on ITPR1, check out the ITPR1 Infographic

ITPR1 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for ITPR1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

Hello CJ!

PB9225 has been cited in 3 publications:

*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.

LncRNA LINC00662 Exerts an Oncogenic Effect on Osteosarcoma by the miR-16-5p/ITPR1 Axis

Ma WQ,Sun XJ,Zhu Y,Liu NF. PDK4 promotes vascular calcification by interfering with autophagic activity and metabolic reprogramming. Cell Death Dis.2020 Nov 17;11(11):991.doi:10.1038/s41419-020-03162-w. PMID:33203874;PMCID:PMC7673024.
Species: Rat
PB9225 usage in article: APP:WB, SAMPLE:VSMCS, DILUTION:NA

Neuroprotective Effect of Kaempferol Glycosides against Brain Injury and Neuroinflammation by Inhibiting the Activation of NF-?B and STAT3 in Transient Focal Stroke

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1 Customer Q&As for Anti-IP3 receptor/ITPR1 Antibody Picoband™

Question

We are currently using anti-IP3 receptor/ITPR1 antibody PB9225 for human tissue, and we are content with the IHC results. The species of reactivity given in the datasheet says human, mouse, rat. Is it possible that the antibody can work on horse tissues as well?

Verified Customer

Verified customer

Asked: 2019-07-15

Answer

The anti-IP3 receptor/ITPR1 antibody (PB9225) has not been tested for cross reactivity specifically with horse tissues, though there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in horse you can get your next antibody for free. Please contact me if I can help you with anything.

Boster Scientific Support

Answered: 2019-07-15

Order DetailsPrice
PB9225

100μg

$370
PB9225-10ug

10μg sample (liquid)

$99
PB9225-Biotin

100 μg Biotin conjugated

$570
PB9225-Cy3

100 μg Cy3 conjugated

$570
PB9225-Dylight488

100 μg Dylight488 conjugated

$570
PB9225-Dylight550

100 μg Dylight550 conjugated

$570
PB9225-Dylight594

100 μg Dylight594 conjugated

$570
PB9225-FITC

100 μg FITC conjugated

$570
PB9225-HRP

100 μg HRP conjugated

$570
PB9225-APC

100 μg APC conjugated

$670
PB9225-PE

100 μg PE conjugated

$670
PB9225-carrier-free

Carrier Free

$370

More conjugates/formats

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PB9225
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$370.00

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