Anti-Lamin A/C LMNA Monoclonal Antibody

Boster Bio Anti-Lamin A/C LMNA Monoclonal Antibody catalog # M00438-1. Tested in IF, WB applications. This antibody reacts with Human.

Product Info Summary

SKU: M00438-1
Size: 100ul
Reactive Species: Human
Host: Mouse
Application: IF, WB

Product Name

Anti-Lamin A/C LMNA Monoclonal Antibody

See all LMNA products

SKU/Catalog Number

M00438-1

Size

100ul

Description

Boster Bio Anti-Lamin A/C LMNA Monoclonal Antibody catalog # M00438-1. Tested in IF, WB applications. This antibody reacts with Human.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Lamin A/C LMNA Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M00438-1)

Host

Mouse

Contents

Purified antibody at 1mg/mL in 50% PBS, 50% glycerol plus 5mM NaN3

Clonality

Monoclonal

Immunogen

Full length recombinant human lamin A expressed in and purified from E. coli.

Reactive Species

M00438-1 is reactive to LMNA in Human

Applications

M00438-1 is guaranteed for IF, WB Boster Guarantee

*Blocking peptide can be purchased at $150. Contact us for more information.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence and ELISA with known positive and negative samples to ensure specificity and high affinity.

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Innovating Scientists Reward

If you are the first to review this product, or if you have results for a special sample, species or application this product is not validated in, share your results with us and receive your next antibody/ELISA kit free of charge! Applicable to all scientists world wide.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. Actual working concentration varies and should be decided by the user.

WB: 1:1,000-1:2,000. IF/ICC 1:1,000

Validation Images & Assay Conditions

Gene/Protein Information For LMNA (Source: Uniprot.Org, NCBI)

Uniprot ID

P02545

Gene ID

4000

Gene Name

LMNA

Full Name

Prelamin-A/C

Weight

74.139kDa

Superfamily

intermediate filament family

Alternative Names

CDCD1; CDDC; CMD1A; CMT2B1; dilated 1A (autosomal dominant); EMD2; FPLD; HGPSFPL; lamin A/C; lamin A/C-like 1; lamin-A/C; LDP1; LFP; LGMD1B; limb girdle muscular dystrophy 1B (autosomal dominant); LMN1IDC; LMNC; LMNL1; prelamin-A/C; PRO1,70 kDa lamin; progeria 1 (Hutchinson-Gilford type); renal carcinoma antigen NY-REN-32 LMNA CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, FPLD2, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, LMNL1, MADA, PRO1 lamin A/C lamin|70 kDa lamin|epididymis secretory sperm binding protein|lamin A/C-like 1|mandibuloacral dysplasia type A|prelamin-A/C|renal carcinoma antigen NY-REN-32

*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".

For more info on LMNA, check out the LMNA Infographic

LMNA infographic

We have 30,000+ of these available, one for each gene! check them out.

In this infographic you will see the following information for LMNA: database IDs, super-family, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact us [email protected]

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5 Customer Q&As for Anti-Lamin A/C LMNA Monoclonal Antibody

Question

We have observed staining in human corpus callosum. Do you have any suggestions? Is anti-Lamin A/C LMNA Monoclonal antibody supposed to stain corpus callosum positively?

Verified Customer

Verified customer

Asked: 2020-02-14

Answer

From literature corpus callosum does express LMNA. From Uniprot.org, LMNA is expressed in mucosa of stomach, corpus callosum, kidney, lung skin, ovarian carcinoma, colon, renal cell carcinoma, cervix carcinoma, cervix carcinoma erythroleukemia, liver, among other tissues. Regarding which tissues have LMNA expression, here are a few articles citing expression in various tissues:
Cervix carcinoma, Pubmed ID: 16964243, 17081983, 17924679, 18220336, 18669648, 18691976, 20068231
Cervix carcinoma, and Erythroleukemia, Pubmed ID: 23186163
Colon, Pubmed ID: 8621584
Corpus callosum, Pubmed ID: 14702039
Kidney, Lung, and Skin, Pubmed ID: 15489334
Liver, Pubmed ID: 24275569
Renal cell carcinoma, Pubmed ID: 10508479, 10514485

Boster Scientific Support

Answered: 2020-02-14

Question

Our lab were satisfied with the WB result of your anti-Lamin A/C LMNA Monoclonal antibody. However we have seen positive staining in corpus callosum isoform c: nucleus speckle using this antibody. Is that expected? Could you tell me where is LMNA supposed to be expressed?

Verified Customer

Verified customer

Asked: 2019-12-16

Answer

From literature, corpus callosum does express LMNA. Generally LMNA expresses in nucleus., isoform c: nucleus speckle. Regarding which tissues have LMNA expression, here are a few articles citing expression in various tissues:
Cervix carcinoma, Pubmed ID: 16964243, 17081983, 17924679, 18220336, 18669648, 18691976, 20068231
Cervix carcinoma, and Erythroleukemia, Pubmed ID: 23186163
Colon, Pubmed ID: 8621584
Corpus callosum, Pubmed ID: 14702039
Kidney, Lung, and Skin, Pubmed ID: 15489334
Liver, Pubmed ID: 24275569
Renal cell carcinoma, Pubmed ID: 10508479, 10514485

Boster Scientific Support

Answered: 2019-12-16

Question

We bought anti-Lamin A/C LMNA Monoclonal antibody for WB on cervix carcinoma a few months ago. I am using human, and We want to use the antibody for IF next. We want examining cervix carcinoma as well as renal cell carcinoma in our next experiment. Do you have any suggestion on which antibody would work the best for IF?

Verified Customer

Verified customer

Asked: 2019-03-13

Answer

I looked at the website and datasheets of our anti-Lamin A/C LMNA Monoclonal antibody and it seems that M00438-1 has been validated on human in both WB and IF. Thus M00438-1 should work for your application. Our Boster satisfaction guarantee will cover this product for IF in human even if the specific tissue type has not been validated. We do have a comprehensive range of products for IF detection and you can check out our website bosterbio.com to find out more information about them.

Boster Scientific Support

Answered: 2019-03-13

Question

I am interested in using your anti-Lamin A/C LMNA Monoclonal antibody for regulation of protein localization to nucleus studies. Has this antibody been tested with western blotting on hela cells? We would like to see some validation images before ordering.

G. Huang

Verified customer

Asked: 2018-04-05

Answer

We appreciate your inquiry. This M00438-1 anti-Lamin A/C LMNA Monoclonal antibody is validated on hela cells. It is guaranteed to work for IF, WB in human. Our Boster guarantee will cover your intended experiment even if the sample type has not been be directly tested.

Boster Scientific Support

Answered: 2018-04-05

Question

We are currently using anti-Lamin A/C LMNA Monoclonal antibody M00438-1 for human tissue, and we are well pleased with the WB results. The species of reactivity given in the datasheet says human. Is it likely that the antibody can work on primate tissues as well?

S. Patel

Verified customer

Asked: 2017-08-04

Answer

The anti-Lamin A/C LMNA Monoclonal antibody (M00438-1) has not been validated for cross reactivity specifically with primate tissues, though there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in primate you can get your next antibody for free. Please contact me if I can help you with anything.

Boster Scientific Support

Answered: 2017-08-04

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M00438-1
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$299.00

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