Anti-LYN Purified Monoclonal Antibody

LYN antibody

Boster Bio Anti-LYN Purified Monoclonal Antibody (Catalog# M01424). Tested in IP, WB, ICC application(s). This antibody reacts with Rat, Human, Mouse.

Product Info Summary

SKU: M01424
Size: 0.1 mg
Reactive Species: Human, Mouse, Rat
Host: Mouse
Application: IP, ICC, WB

Product Name

Anti-LYN Purified Monoclonal Antibody

View all LYN Antibodies

SKU/Catalog Number

M01424

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-LYN Purified Monoclonal Antibody (Catalog# M01424). Tested in IP, WB, ICC application(s). This antibody reacts with Rat, Human, Mouse.

Storage & Handling

Store at 2-8°C. Do not freeze.

Cite This Product

Anti-LYN Purified Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M01424)

Host

Mouse

Contents

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Clonality

Monoclonal

Clone Number

LYN-01

Isotype

Mouse IgG1

Immunogen

Bacterially expressed recombinant fragment of human Lyn (aa 8 - 238). The antibody LYN-01 reacts with Lyn (p56/p53), a non-receptor Src-family tyrosine kinase expressed in hematopoietic tissues (intracellular antigen).

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

M01424 is reactive to LYN in Human, Mouse, Rat

Applications

M01424 is guaranteed for IP, ICC, WB Boster Guarantee

Observed Molecular Weight

42 kDa

Calculated molecular weight

58.574kDa

Background of LYN

Lyn is a Src-family protein tyrosine kinase that is predominantly expressed in hematopoietic cells. It is associated with a number of cell surface receptors including the B cell antigen receptor (BCR) and Fc receptors. Upon their triggering, Lyn phosphorylates subunits of these receptors in a cholesterol-dependent manner, utilizing the plasma membrane lipid raft system. The phosphorylated intracellular domains of the receptors are accessible for cytoplasmic Syk tyrosine kinase, which is activated by Lyn-mediated phosphorylation and which transduces the signal to downstream adaptors. Lyn is abnormally distributed in acute myeloid leukemia cells and seems to be a novel pharmacologic target of this disease.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blotting: 1-2 μg/ml.

Validation Images & Assay Conditions

Gene/Protein Information For LYN (Source: Uniprot.org, NCBI)

Gene Name

LYN

Full Name

Tyrosine-protein kinase Lyn

Weight

58.574kDa

Superfamily

protein kinase superfamily

Alternative Names

EC 2.7.10; EC 2.7.10.2; FLJ26625; Hck-2; JTK8; Lyn; tyrosine-protein kinase Lyn; v-yes-1 Yamaguchi sarcoma viral related oncogene homolog; v-yes-1; Yamaguchi sarcoma viral (v-yes-1) related oncogene homolog LYN JTK8, p53Lyn, p56Lyn LYN proto-oncogene, Src family tyrosine kinase tyrosine-protein kinase Lyn|lck/Yes-related novel protein tyrosine kinase|v-yes-1 Yamaguchi sarcoma viral related oncogene homolog

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on LYN, check out the LYN Infographic

LYN infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for LYN: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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Order DetailsPrice
M01424

0.1 mg

$326

Free Secondary Antibody

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M01424
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$326.00

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