Product Info Summary
SKU: | A05396-1 |
---|---|
Size: | 100ul |
Reactive Species: | Human, Mouse, Rat |
Host: | Rabbit |
Application: | IF, IHC, WB |
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Product info
Product Name
Anti-NIPP1 PPP1R8 Antibody
SKU/Catalog Number
A05396-1
Size
100ul
Form
Liquid
Description
Boster Bio Anti-NIPP1 PPP1R8 Antibody catalog # A05396-1. Tested in WB,IHC,IF applications. This antibody reacts with Human,Mouse,Rat.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-NIPP1 PPP1R8 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A05396-1)
Host
Rabbit
Contents
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from human CNG-1beta
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A05396-1 is reactive to PPP1R8 in Human, Mouse, Rat
Applications
A05396-1 is guaranteed for IF, IHC, WB Boster Guarantee
Observed Molecular Weight
111 kDa
Calculated molecular weight
38.479kDa
Background of NIPP1
Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis.
Beebe S.J., Mol. Endocrinol. 4:465-475(1990).
Gregory S.G., Nature 441:315-321(2006).
Wu K.-J., Oncogene 21:7872-7882(2002).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB: 1:500-1:2000
IHC/IF: 1:50-1:200
Validation Images & Assay Conditions
Click image to see more details
Figure 1. Western blotting validation for Anti-NIPP1 PPP1R8 Antibody A05396-1
Western blot analysis of extracts of various cell linesProtein Target Info & Infographic
Gene/Protein Information For PPP1R8 (Source: Uniprot.org, NCBI)
Gene Name
PPP1R8
Full Name
Nuclear inhibitor of protein phosphatase 1
Weight
38.479kDa
Alternative Names
activator of RNA decay; ARD1; ard-1; ARD1nuclear inhibitor of protein phosphatase 1; NIPP1; NIPP1nuclear inhibitor of protein phosphatase-1; NIPP-1nuclear subunit of PP-1; PPP1R8; PRO2047; Protein phosphatase 1 regulatory inhibitor subunit 8; protein phosphatase 1 regulatory subunit 8; protein phosphatase 1, regulatory (inhibitor) subunit 8; RNase E PPP1R8 ARD-1, ARD1, NIPP-1, NIPP1, PRO2047 protein phosphatase 1 regulatory subunit 8 nuclear inhibitor of protein phosphatase 1|RNase E|activator of RNA decay|nuclear inhibitor of protein phosphatase-1 alpha|nuclear inhibitor of protein phosphatase-1 beta|nuclear subunit of PP-1|protein phosphatase 1, regulatory (inhibitor) subunit 8
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on PPP1R8, check out the PPP1R8 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for PPP1R8: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-NIPP1 PPP1R8 Antibody (A05396-1)
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No publications found for A05396-1
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