Anti-Phospho-NMDA Receptor NR2A Subunit (Tyr1325) GRIN2A Antibody

GRIN2A antibody

Boster Bio Anti-Phospho-NMDA Receptor NR2A Subunit (Tyr1325) GRIN2A Antibody (Catalog # P01949). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. Cited in 1 publication(s).

Product Info Summary

SKU: P01949
Size: 100 µl
Reactive Species: Human, Mouse, Rat
Host: Rabbit
Application: WB

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Product Name

Anti-Phospho-NMDA Receptor NR2A Subunit (Tyr1325) GRIN2A Antibody

View all GRIN2A Antibodies

SKU/Catalog Number

P01949

Size

100 µl

Form

Liquid

Description

Boster Bio Anti-Phospho-NMDA Receptor NR2A Subunit (Tyr1325) GRIN2A Antibody (Catalog # P01949). Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C. After date of receipt, stable for at least 1 year at -20°C.

Cite This Product

Anti-Phospho-NMDA Receptor NR2A Subunit (Tyr1325) GRIN2A Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # P01949)

Host

Rabbit

Contents

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Clonality

Polyclonal

Clone Number

608

Isotype

IgG

Immunogen

Synthetic phospho-peptide corresponding to amino acid residues surrounding Tyr1325 of the rat NMDA receptor, conjugated to keyhole limpet hemocyanin (KLH). Immunogen species is Rat.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross reactivity with other proteins.

Reactive Species

P01949 is reactive to GRIN2A in Human, Mouse, Rat

Applications

P01949 is guaranteed for WB Boster Guarantee

Observed Molecular Weight

52 kDa

Calculated molecular weight

165.283kDa

Background of GRIN2A

The ion channels activated by glutamate that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer’s, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002; Wenthold et al., 2003; Carroll and Zukin, 2002). The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS (Lovinger et al., 1989; Alvestad et al., 2003; Snell et al., 1996). Channels with physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits (Ishii et al., 1993). Recently, phosphorylation of Tyrosine 1325 of the NR2A subunit has been shown to be increased in human brain tissue sections from HIV-infected individuals with encephalitis (King et al., 2010). In addition, Tyr-1325 phosphorylation has been linked with depression-related behavior (Taniguchi et al., 2009).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB: 1:1000

Validation Images & Assay Conditions

Gene/Protein Information For GRIN2A (Source: Uniprot.org, NCBI)

Gene Name

GRIN2A

Full Name

Glutamate receptor ionotropic, NMDA 2A

Weight

165.283kDa

Superfamily

glutamate-gated ion channel (TC 1.A.10.1) family

Alternative Names

glutamate receptor, ionotropic, N-methyl D-aspartate 2A; hNR2A; NMDA receptor subtype 2A; N-methyl D-aspartate receptor subtype 2A; N-methyl-D-aspartate receptor subunit 2A; subunit epsilon-1 GRIN2A EPND, FESD, GluN2A, LKS, NMDAR2A, NR2A glutamate ionotropic receptor NMDA type subunit 2A glutamate receptor ionotropic, NMDA 2A|N-methyl D-aspartate receptor subtype 2A|N-methyl-D-aspartate receptor channel, subunit epsilon-1|N-methyl-D-aspartate receptor subunit 2A|glutamate ionotropic receptor NMDA 2A|glutamate receptor, ionotropic, N-methyl D-aspartate 2A

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on GRIN2A, check out the GRIN2A Infographic

GRIN2A infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for GRIN2A: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

Hello CJ!

P01949 has been cited in 1 publications:

*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.

Liang Y,Ma Y,Wang J,Nie L,Hou X,Wu W,Zhang X,Tian Y. Leptin Contributes to Neuropathic Pain via Extrasynaptic NMDAR-nNOS Activation. Mol Neurobiol.2020 Oct 25.doi:10.1007/s12035-020-02180-1.Epub ahead of print.PMID:33099751.
Species: Rat
P01949 usage in article: APP:WB, SAMPLE:DRG NEURONS, DILUTION:1:400

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Order DetailsPrice
P01949

100uL

$465

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