Anti-p23 Monoclonal Antibody

p23/PTGES3 antibody

Boster Bio Anti-p23 Monoclonal Antibody catalog # M04136-1. Tested in ELISA, IP, IF, IHC, WB applications. This antibody reacts with Human, Mouse.

Product Info Summary

SKU: M04136-1
Size: 100ug
Reactive Species: Chicken, Guinea pig, Human, Mouse, Rabbit, Yeast
Host: Mouse
Application: ELISA, IP, IF, IHC, ICC, WB, Antibody Microarray

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Product Name

Anti-p23 Monoclonal Antibody

View all p23/PTGES3 Antibodies

SKU/Catalog Number

M04136-1

Size

100ug

Form

liquid

Description

Boster Bio Anti-p23 Monoclonal Antibody catalog # M04136-1. Tested in ELISA, IP, IF, IHC, WB applications. This antibody reacts with Human, Mouse.

Storage & Handling

Store at -20°C for one year. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-p23 Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M04136-1)

Host

Mouse

Contents

PBS, 50% glycerol, 0.09% sodium azide

Clonality

Monoclonal

Clone Number

JJ6

Isotype

IgG1

Immunogen

Recombinant human full length p23 protein

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

Detects ~23kDa.

Reactive Species

M04136-1 is reactive to PTGES3 in Chicken, Guinea pig, Human, Mouse, Rabbit, Yeast

Applications

M04136-1 is guaranteed for ELISA, IP, IF, IHC, ICC, WB, Antibody Microarray Boster Guarantee

Observed Molecular Weight

42 kDa

Calculated molecular weight

18.697kDa

Background of p23/PTGES3

p23 is a highly conserved ubiquitous protein, known to have an important function as a cochaperone for the HSP90 chaperoning system (1). Studies have revealed that p23 is a small protein (18 to 25 kDa) with a simple structure (2, 3). p23 does not have any structural homology with any other known proteins (1). p23 was first discovered as a part of the HSP90-progesterone receptor complex along with HSP70, p54 and p50 (1). p23 is a phosphor-protein, which is highly acidic and has an aspartic acid-rich c-terminal domain (1). Numerous studies have found p23 to be associated with other client proteins like Fes tyrosine kinase (4), the heme regulated kinase HRI (5), hsf1 transcription factor (4), aryl hydrocarbon receptor (4), telomerase (6), and Hepadnavirus reverse transcriptase (7). In spite of several years of study, the exact functional significance of p23 is still not clear (8). p23 is thought to be involved in the adenosine triphosphate–mediated HSP90 binding of client proteins (8). Since many HSP90 client proteins are involved in oncogenic survival signaling, a recent study has concluded p23 to be a promising target in leukemic apoptosis (9). HSP90 and its co-chaperone p23 are certainly among the emerging anti-tumor targets in oncology.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB (1:2000) IHC (1:100), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Validation Images & Assay Conditions

Gene/Protein Information For PTGES3 (Source: Uniprot.org, NCBI)

Gene Name

PTGES3

Full Name

Prostaglandin E synthase 3

Weight

18.697kDa

Superfamily

p23/wos2 family

Alternative Names

CPGES; cPGESp23; Cytosolic prostaglandin E2 synthase; Hsp90 co-chaperone; p23; P23cytosolic prostaglandin E synthase; Progesterone receptor complex p23; prostaglandin E synthase 3 (cytosolic); prostaglandin E synthase 3; PTGES3; TEBP; TEBPEC 5.3.99.3; Telomerase-binding protein p23; unactive progesterone receptor, 23 kD PTGES3 P23, TEBP, cPGES prostaglandin E synthase 3 prostaglandin E synthase 3|Hsp90 co-chaperone|cytosolic prostaglandin E synthase|cytosolic prostaglandin E2 synthase|progesterone receptor complex p23|prostaglandin E synthase 3 (cytosolic)|telomerase-binding protein p23|unactive progesterone receptor, 23 kD

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on PTGES3, check out the PTGES3 Infographic

PTGES3 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for PTGES3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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Order DetailsPrice
M04136-1

100 μg

$343

Free Secondary Antibody

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M04136-1
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$343.00

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