Anti-p53R2/RRM2B Antibody

p53R2 antibody

Boster Bio Anti-p53R2/RRM2B Antibody catalog # PA2053. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Product Info Summary

SKU: PA2053
Size: 100 μg/vial
Reactive Species: Human, Mouse, Rat
Host: Rabbit
Application: WB

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Product Name

Anti-p53R2/RRM2B Antibody

View all p53R2 Antibodies

SKU/Catalog Number

PA2053

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-p53R2/RRM2B Antibody catalog # PA2053. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-p53R2/RRM2B Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA2053)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human p53R2, identical to the related rat and mouse sequences.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

PA2053 is reactive to RRM2B in Human, Mouse, Rat

Applications

PA2053 is guaranteed for WB Boster Guarantee

Observed Molecular Weight

83 kDa

Calculated molecular weight

40.737kDa

Background of p53R2

RRM2B (Ribonucleotide Reductase, M2 B), also known as P53R2, is an enzyme that in humans is encoded by the RRM2B gene. Tanaka et al. (2000) mapped the p53R2 gene to chromosome 8q23.1 by fluorescence in situ hybridization. Tanaka et al. (2000) found that expression of p53R2, but not R2, was induced by ultraviolet and gamma-irradiation and adriamycin treatment in a wildtype p53-dependent manner. Induction of p53R2 in p53-deficient cells caused G2/M arrest and protected cells from death in response to adriamycin. Inhibition of endogenous p53R2 expression in cells that had an intact p53-dependent DNA damage checkpoint reduced ribonucleotide reductase activity, DNA repair, and cell survival after exposure to various genotoxins.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Reconsitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blot, 0.1-0.5μg/ml, Human, Rat, Mouse

Validation Images & Assay Conditions

Gene/Protein Information For RRM2B (Source: Uniprot.org, NCBI)

Gene Name

RRM2B

Full Name

Ribonucleoside-diphosphate reductase subunit M2 B

Weight

40.737kDa

Superfamily

ribonucleoside diphosphate reductase small chain family

Alternative Names

EC 1.17.4.1; MGC102856; MGC42116; MTDPS8A; MTDPS8B; p53-inducible ribonucleotide reductase small subunit 2 homolog; p53-inducible ribonucleotide reductase small subunit 2-like protein; p53R2; P53R2DKFZp686M05248; PEOA5; ribonucleoside-diphosphate reductase subunit M2 B; ribonucleotide reductase M2 B (TP53 inducible); RRM2B; TP53-inducible ribonucleotide reductase M2 B RRM2B MTDPS8A, MTDPS8B, P53R2 ribonucleotide reductase regulatory TP53 inducible subunit M2B ribonucleoside-diphosphate reductase subunit M2 B|TP53-inducible ribonucleotide reductase M2 B|p53-inducible ribonucleotide reductase small subunit 2 homolog|p53-inducible ribonucleotide reductase small subunit 2 short form beta|p53-inducible ribonucleotide reductase small subunit 2-like protein|ribonucleotide reductase M2 B (TP53 inducible)

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on RRM2B, check out the RRM2B Infographic

RRM2B infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for RRM2B: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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1 Customer Q&As for Anti-p53R2/RRM2B Antibody

Question

We are currently using anti-p53R2/RRM2B antibody PA2053 for rat tissue, and we are satisfied with the WB results. The species of reactivity given in the datasheet says human, mouse, rat. Is it likely that the antibody can work on feline tissues as well?

Verified Customer

Verified customer

Asked: 2018-05-07

Answer

The anti-p53R2/RRM2B antibody (PA2053) has not been validated for cross reactivity specifically with feline tissues, though there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in feline you can get your next antibody for free. Please contact me if I can help you with anything.

Boster Scientific Support

Answered: 2018-05-07

Order DetailsPrice
PA2053

100μg

$370
PA2053-10ug

10μg sample (liquid)

$99
PA2053-Biotin

100 μg Biotin conjugated

$570
PA2053-Cy3

100 μg Cy3 conjugated

$570
PA2053-Dylight488

100 μg Dylight488 conjugated

$570
PA2053-Dylight550

100 μg Dylight550 conjugated

$570
PA2053-Dylight594

100 μg Dylight594 conjugated

$570
PA2053-FITC

100 μg FITC conjugated

$570
PA2053-HRP

100 μg HRP conjugated

$570
PA2053-APC

100 μg APC conjugated

$670
PA2053-PE

100 μg PE conjugated

$670
PA2053-carrier-free

Carrier Free

$370

More conjugates/formats

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Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$370.00

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