Anti-PDH-E1 alpha PDHA1 Monoclonal Antibody

Pyruvate Dehydrogenase E1-alpha subunit antibody

Boster Bio Anti-PDH-E1 alpha PDHA1 Monoclonal Antibody catalog # A01906-2. Tested in IF, IHC, WB applications. This antibody reacts with Bovine, Human, Mouse, Pig, Rat.

Product Info Summary

SKU: A01906-2
Size: 100μl
Reactive Species: Bovine, Human, Mouse, Pig, Rat
Host: Mouse
Application: IF, IHC, WB

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Product Name

Anti-PDH-E1 alpha PDHA1 Monoclonal Antibody

View all Pyruvate Dehydrogenase E1-alpha subunit Antibodies

SKU/Catalog Number

A01906-2

Size

100μl

Form

Liquid

Description

Boster Bio Anti-PDH-E1 alpha PDHA1 Monoclonal Antibody catalog # A01906-2. Tested in IF, IHC, WB applications. This antibody reacts with Bovine, Human, Mouse, Pig, Rat.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-PDH-E1 alpha PDHA1 Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01906-2)

Host

Mouse

Contents

Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.

Clonality

Monoclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from human PDHA1

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross reactivity with other proteins.

Reactive Species

A01906-2 is reactive to PDHA1 in Bovine, Human, Mouse, Pig, Rat

Applications

A01906-2 is guaranteed for IF, IHC, WB Boster Guarantee

Observed Molecular Weight

39 kDa

Calculated molecular weight

43.296kDa

Background of Pyruvate Dehydrogenase E1-alpha subunit

CaM Kinase IV (also known as CAM kinase-GR and CaMK IV) is a calcium/ calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. This kinase may be involved in the transcriptional regulation of microtubule dynamics. In vitro, CaMK IV phosphorylates CREB1, CREBBP, PRM2, MEF2A, MEF2D and STMN1/OP18. CaMK IV may also be involved in spermatogenesis and may play a role in the consolidation/ retention of hippocampus-dependent long-term memory. CaMK IV must be phosphorylated to be maximally active and is phosphorylated by CAMKK1 or CAMKK2. In addition autophosphorylation of the N-terminus is required for full activation. Autophosphorylation of Ser-336 allows the kinase to switch to a Ca(2+)/calmodulin-independent state. Most likely the kinase is inactivated by the serine/ threonine protein phosphatase 2A. CaMK IV is a monomer that is located within the cytoplasm and nucleus and substantial localization occurs in certain neuronal nuclei. In spermatids CaMK IV is associated with chromatin and the nuclear matrix. CaMK IV is also specifically expressed in epithelial ovarian cancer tissue.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Reconsitution

Restore with deionized water (or equivalent) for reconstitution volume of 100 µL

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB, 1:1000-1:2000
IF, 1:100-1:500

Validation Images & Assay Conditions

Gene/Protein Information For PDHA1 (Source: Uniprot.org, NCBI)

Gene Name

PDHA1

Full Name

Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

Weight

43.296kDa

Alternative Names

EC 1.2.4.1; PDHA; PDHE1-A type I; PHE1APDHCE1A; pyruvate dehydrogenase (lipoamide) alpha 1; pyruvate dehydrogenase complex, E1-alpha polypeptide 1; pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial PDHA1 PDHA, PDHAD, PDHCE1A, PHE1A pyruvate dehydrogenase E1 subunit alpha 1 pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial|PDHE1-A type I|pyruvate dehydrogenase (lipoamide) alpha 1|pyruvate dehydrogenase E1 alpha 1 subunit|pyruvate dehydrogenase alpha 1|pyruvate dehydrogenase complex, E1-alpha polypeptide 1

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on PDHA1, check out the PDHA1 Infographic

PDHA1 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for PDHA1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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Order DetailsPrice
A01906-2

100uL

$399

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A01906-2
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$399.00

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