Anti-PMS2 Monoclonal Antibody

PMS2 antibody

Boster Bio Anti-PMS2 Monoclonal Antibody (Catalog # M01028). Tested in ELISA, WB applications. This antibody reacts with Human.

Product Info Summary

SKU: M01028
Size: 100ug
Reactive Species: Human
Host: Mouse
Application: ELISA, WB

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Product Name

Anti-PMS2 Monoclonal Antibody

View all PMS2 Antibodies

SKU/Catalog Number

M01028

Size

100ug

Form

Liquid (sterile filtered)

Description

Boster Bio Anti-PMS2 Monoclonal Antibody (Catalog # M01028). Tested in ELISA, WB applications. This antibody reacts with Human.

Storage & Handling

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.

Cite This Product

Anti-PMS2 Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M01028)

Host

Mouse

Contents

0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2, 0.01% (w/v) Sodium Azide

Clonality

Monoclonal

Clone Number

Clone: 1204

Isotype

IgG1 kappa

Immunogen

This protein A purified monoclonal antibody was produced by repeated immunizations with recombinant human PMS2 corresponding to the first 133 amino acid residues of the protein. The clone was produced using conventional hybridoma technology.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross reactivity with other proteins.

Reactive Species

M01028 is reactive to PMS2 in Human

Applications

M01028 is guaranteed for ELISA, WB Boster Guarantee

Observed Molecular Weight

42 kDa

Calculated molecular weight

95.797kDa

Background of PMS2

PMS2 is a highly conserved nuclear protein involved in mismatch repair during DNA replication and has been identified to be composed as a heterodimer of PMS2 and MLH1. PMS is part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBS1 protein complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Defects in PMS2 are the cause of hereditary non-polyposis colorectal cancer type 4 (HNPCC4), Turcot syndrome (an autosomal dominant disorder characterized by malignant tumors of the brain associated with multiple colorectal adenomas) and supratentorial primitive neuroectodermal tumors with cafe-au-lait spots (SNTCL). The human PMS2 gene encodes an 862 aa, 96 kDa polypeptide.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

ELISA: 1:5,000 - 1:20,000
WB: 1:500 - 1:2,000

Validation Images & Assay Conditions

Gene/Protein Information For PMS2 (Source: Uniprot.org, NCBI)

Gene Name

PMS2

Full Name

Mismatch repair endonuclease PMS2

Weight

95.797kDa

Superfamily

DNA mismatch repair MutL/HexB family

Alternative Names

DNA mismatch repair protein PMS2; EC 3.1; H_DJ0042M02.9; HNPCC4postmeiotic segregation increased (S. cerevisiae) 2; mismatch repair endonuclease PMS2; PMS1 protein homolog 2; PMS2 postmeiotic segregation increased 2 (S. cerevisiae); PMSL2PMS2CL PMS2 HNPCC4, MLH4, MMRCS4CL, PMSL2, PMS2 PMS1 homolog 2, mismatch repair system component mismatch repair endonuclease PMS2|DNA mismatch repair protein PMS2|PMS1 homolog 2, mismatch repair protein|PMS1 protein homolog 2|PMS2 postmeiotic segregation increased 2|postmeiotic segregation increased 2 nirs variant 6

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on PMS2, check out the PMS2 Infographic

PMS2 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for PMS2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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Order DetailsPrice
M01028

100 μg

$612

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M01028
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
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