Product Info Summary
SKU: | M01557 |
---|---|
Size: | 100ul |
Reactive Species: | Human, Mouse, Rat |
Host: | Mouse |
Application: | IHC |
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Product info
Product Name
Anti-PPAR Delta Monoclonal Antibody
View all PPAR delta/NR1C2 Antibodies
SKU/Catalog Number
M01557
Size
100ul
Form
Liquid
Description
Boster Bio Anti-PPAR Delta Monoclonal Antibody catalog # M01557. Tested in IHC applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-PPAR Delta Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M01557)
Host
Mouse
Contents
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Clonality
Monoclonal
Clone Number
2F9
Isotype
IgG
Immunogen
Recombinant peptide derived from PPAR Delta
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
M01557 is reactive to PPARD in Human, Mouse, Rat
Applications
M01557 is guaranteed for IHC Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
49.903kDa
Background of PPAR delta/NR1C2
Bin1 is a conserved member of the BAR family of genes that have been implicated in diverse cellular processes including endocytosis, actin organization, programmed cell death, stress responses, and transcriptional control. The first mammalian BAR protein to be discovered, Amphiphysin I (AmphI), was identified in an immunoscreen for proteins associated with the plasma membranes of synaptic neurons, functions in the control of clathrin-dependent synaptic vesicle endocytosis. The mammalian Bin1 gene was first identified in a two hybrid screen for polypeptides that bind to the N-terminal Myc box 1 (MB1) portion of the c-Myc oncoprotein. Bin1 is similar to AmphI in overall structure, with an N-terminal BAR domain and a C-terminal SH3 domain. However, the Bin1 gene is more complex than the AmphI gene, encoding at least seven different splice variants that differ widely in subcellular localization, tissue distribution, and ascribed functions. Alternate splicing of the Bin1 gene results in ten transcript variants encoding different isoform. Bin1 is expressed ubiquitously in mammalian cells. Certain splice variants of Bin1 are expressed in the neurons, muscle cells or tumor cells. Bin1 may act as a cancer suppressor and inhibits malignant cell transformation. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Bin1 has also been implicated in Alzheimer disease and cardiac disease. Defects in Bin1 are the cause of centronuclear myopathy autosomal recessive; also known as autosomal recessive myotubular myopathy.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
IHC 1:100-200
Validation Images & Assay Conditions
Click image to see more details
Figure 1. Immunohistochemistry validation of PPARD using Anti-PPAR Delta Monoclonal Antibody (M01557).
Immunohistochemistry (IHC) analysis of paraffin-embedded Mouse Brain Tissue using PPAR Delta Mouse monoclonal antibody diluted at 1:200.For more protocol information of IHC
Click image to see more details
Figure 2. Immunohistochemistry validation of PPARD using Anti-PPAR Delta Monoclonal Antibody (M01557).
Immunohistochemical analysis of human-liver tissue. Anti-PPAR Delta at 1:200 (4°CClick image to see more details
Figure 3. Immunohistochemistry validation of PPARD using Anti-PPAR Delta Monoclonal Antibody (M01557).
Immunohistochemical analysis of human lung tissue. Anti-PPAR Delta at 1:200 (4°CClick image to see more details
Figure 4. Immunohistochemistry validation of PPARD using Anti-PPAR Delta Monoclonal Antibody (M01557).
Immunohistochemical analysis of human uterus tissue. Anti-PPAR Delta at 1:200 (4°CClick image to see more details
Figure 5. Immunohistochemistry validation of PPARD using Anti-PPAR Delta Monoclonal Antibody (M01557).
Immunohistochemical analysis of mouse lung tissue. Anti-PPAR Delta at 1:200 (4°CClick image to see more details
Figure 6. Immunohistochemistry validation of PPARD using Anti-PPAR Delta Monoclonal Antibody (M01557).
Immunohistochemistry (IHC) analysis of paraffin-embedded Human Brain Tissue using PPAR Delta Mouse monoclonal antibody diluted at 1:200.For more protocol information of IHC
Protein Target Info & Infographic
Gene/Protein Information For PPARD (Source: Uniprot.org, NCBI)
Gene Name
PPARD
Full Name
Peroxisome proliferator-activated receptor delta
Weight
49.903kDa
Superfamily
nuclear hormone receptor family
Alternative Names
FAAR; MGC3931; NR1C2; NR1C2PPAR-delta; NUC1; NUC1PPAR-beta; NUCI; NUCII; Nuclear hormone receptor 1; Nuclear receptor subfamily 1 group C member 2; peroxisome proliferative activated receptor, delta; Peroxisome proliferator-activated receptor beta; peroxisome proliferator-activated receptor delta; PPAR delta; PPARB; PPARD PPARD FAAR, NR1C2, NUC1, NUCI, NUCII, PPARB peroxisome proliferator activated receptor delta peroxisome proliferator-activated receptor delta|PPAR-beta|PPAR-delta|PPARD/MYO1D fusion|nuclear hormone receptor 1|nuclear receptor subfamily 1 group C member 2|peroxisome proliferator-activated receptor beta
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on PPARD, check out the PPARD Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for PPARD: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-PPAR Delta Monoclonal Antibody (M01557)
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No publications found for M01557
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