Anti-Protein C/PROC Antibody

Coagulation Factor XIV/Protein C antibody

Boster Bio Anti-Protein C/PROC Antibody catalog # PA1682. Tested in Flow Cytometry, IHC, ICC, WB applications. This antibody reacts with Human. Cited in 10 publication(s).

Product Info Summary

SKU: PA1682
Size: 100 μg/vial
Reactive Species: Human
Host: Rabbit
Application: Flow Cytometry, IHC, ICC, WB

Product Name

Anti-Protein C/PROC Antibody

View all Coagulation Factor XIV/Protein C Antibodies

SKU/Catalog Number

PA1682

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-Protein C/PROC Antibody catalog # PA1682. Tested in Flow Cytometry, IHC, ICC, WB applications. This antibody reacts with Human.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Protein C/PROC Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1682)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human Protein C.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

PA1682 is reactive to PROC in Human

Applications

PA1682 is guaranteed for Flow Cytometry, IHC, ICC, WB Boster Guarantee

Observed Molecular Weight

36 kDa

Calculated molecular weight

52.071kDa

Background of Coagulation Factor XIV/Protein C

Protein C (PROC), also called PC, is a zymogenic (inactive) protein, the activated form of which plays an important role in regulating blood clotting, inflammation, cell death and maintaining the permeability of blood vessel walls in humans and other animals. The PROC gene is mapped on 2q14.3. The PROC gene contains 8 exons and spans about 11 kb by Foster et al. The conversion of protein C to a protease with anticoagulant function by thrombin requires as a cofactor thrombomodulin, an endothelial cell membrane protein. Riewald et al. demonstrated that activated protein C uses the endothelial cell protein C receptor as a coreceptor for cleavage of protease-activated receptor-1 on endothelial cells. Faust et al. demonstrated that the endothelial pathways required for protein C activation are impaired in severe meningococcal sepsis. They stated that improvement in the outcome of children with meningococcal sepsis who were treated with unactivated protein C concentrates had been described in case reports and in 1 uncontrolled series.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Reconsitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, By Heat
Western blot, 0.1-0.5μg/ml, Human
Immunohistochemistry (Frozen Section), 0.5-1μg/ml, Human
Immunocytochemistry, 0.5-1μg/ml, Human
Flow Cytometry, 1-3μg/1x106 cells, Human

Validation Images & Assay Conditions

Gene/Protein Information For PROC (Source: Uniprot.org, NCBI)

Gene Name

PROC

Full Name

Vitamin K-dependent protein C

Weight

52.071kDa

Superfamily

peptidase S1 family

Alternative Names

Anticoagulant protein C; APC; Autoprothrombin IIA; Blood coagulation factor XIV; Coagulation Factor XIV; EC 3.4.21; EC 3.4.21.69; PC; PROC; PROC1; protein C (inactivator of coagulation factors Va and VIIIa); Protein C; vitamin K-dependent protein C PROC APC, PC1, THPH3, THPH4, PROC protein C, inactivator of coagulation factors Va and VIIIa vitamin K-dependent protein C|Protein C-Nagoya|activated protein C|anticoagulant protein C|autoprothrombin IIA|blood coagulation factor XIV|prepro-protein C|type I protein C

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on PROC, check out the PROC Infographic

PROC infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for PROC: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

Hello CJ!

PA1682 has been cited in 10 publications:

*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.

Chen Aq, Liu Zw, Yang Zg, Leng Xj. Comp Biochem Physiol B Biochem Mol Biol. 2012 Sep;163(1):121-8. Doi: 10.1016/J.Cbpb.2012.05.009. Epub 2012 May 18. Characterization Of Bmp15 And Its Regulation By Human Chorionic Gonadotropin In The Follicle Of G...

Zhang S, He B, Goldstein S, Ge J, Wang Z, Ruiz G. Virol J. 2010 Oct 27;7:285. Doi: 10.1186/1743-422X-7-285. The Expression And Significance Of Proto-Oncogene C-Fos In Viral Myocarditis.

Zhang S, Zhang M, Goldstein S, Li Y, Ge J, He B, Ruiz G. Cell Biochem Biophys. 2013 Mar;65(2):249-55. Doi: 10.1007/S12013-012-9428-0. The Effect Of C-Fos On Acute Myocardial Infarction And The Significance Of Metoprolol Intervention In A Rat Model.

Tang Y, Li Y, Yu H, Gao C, Liu L, Chen S, Xing M, Liu L, Yao P. J Nutr Biochem. 2014 Jun;25(6):675-82. Doi: 10.1016/J.Jnutbio.2014.02.009. Epub 2014 Mar 19. Quercetin Prevents Ethanol-Induced Iron Overload By Regulating Hepcidin Through The Bmp6/S...

Bao Hj, Liu Y, Qin Jh, Xu Cs, Hei Nn, Jaber Jr, Chen Qs. Res Vet Sci. 2011 Dec;91(3):E16-24. Doi: 10.1016/J.Rvsc.2011.02.015. Epub 2011 Apr 12. An Immunohistochemical Study Of S-100 Protein In The Intestinal Tract Of Chinese Soft-Shelled Turtle, P...

Ban Jb, Fan Xw, Huang Q, Li Bf, Chen C, Zhang Hc, Xu Sq. Plos One. 2014 May 16;9(5):E97607. Doi: 10.1371/Journal.Pone.0097607. Ecollection 2014. Mono-(2-Ethylhexyl) Phthalate Induces Injury In Human Umbilical Vein Endothelial Cells.

Yang H, Gu J, Zheng Q, Li M, Lian X, Miao J, Jiang J, Wei W. J Biol Chem. 2011 Apr 1;286(13):11865-74. Doi: 10.1074/Jbc.M110.136929. Epub 2011 Feb 10. Rpb5-Mediating Protein Is Required For The Proliferation Of Hepatocellular Carcinoma Cells.

Li Jt, Wang Lf, Zhao Yl, Yang T, Li W, Zhao J, Yu F, Wang L, Meng Yl, Liu Nn, Zhu Xs, Gao Cf, Jia Lt, Yang Ag. Breast Cancer Res. 2014 Oct 14;16(5):454. Doi: 10.1186/S13058-014-0454-2. Nuclear Factor Of Activated T Cells 5 Maintained By Hotair Sup...

Liu R, An L, Liu G, Li X, Tang W, Chen X. Antiviral Res. 2015 Aug;120:101-11. Doi: 10.1016/J.Antiviral.2015.05.008. Epub 2015 May 27. Mouse Lung Slices: An Ex Vivo Model For The Evaluation Of Antiviral And Anti-Inflammatory Agents Against Influenz...

Aksu I, Baykara B, Kiray M, Gurpinar T, Sisman Ar, Ekerbicer N, Tas A, Gokdemir-Yazar O, Uysal N. Biotech Histochem. 2013 May;88(3-4):194-201. Doi: 10.3109/10520295.2012.758311. Epub 2013 Jan 21. Serum Igf-1 Levels Correlate Negatively To Liver Da...

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3 Customer Q&As for Anti-Protein C/PROC Antibody

Question

We are currently using anti-Protein C/PROC antibody PA1682 for human tissue, and we are satisfied with the IHC results. The species of reactivity given in the datasheet says human. Is it possible that the antibody can work on goat tissues as well?

Verified Customer

Verified customer

Asked: 2019-11-08

Answer

The anti-Protein C/PROC antibody (PA1682) has not been tested for cross reactivity specifically with goat tissues, though there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in goat you can get your next antibody for free. Please contact me if I can help you with anything.

Boster Scientific Support

Answered: 2019-11-08

Question

Would PA1682 anti-Protein C/PROC antibody work on parafin embedded sections? If so, which fixation method do you recommend we use (PFA, paraformaldehyde, other)?

Verified Customer

Verified customer

Asked: 2018-08-27

Answer

As indicated on the product datasheet, PA1682 anti-Protein C/PROC antibody as been tested on IHC. It is best to use PFA for fixation because it has better tissue penetration ability. PFA needs to be prepared fresh before use. Long term stored PFA turns into formalin, as the PFA molecules congregate and become formalin.

Boster Scientific Support

Answered: 2018-08-27

Question

We appreciate helping with my inquiry over the phone. Here are the WB image, lot number and protocol we used for blood using anti-Protein C/PROC antibody PA1682. Let me know if you need anything else.

Verified Customer

Verified customer

Asked: 2017-11-30

Answer

We appreciate the data. You have provided everything we needed. Our lab team are working to resolve your inquiry as quickly as possible, and we appreciate your patience and understanding! Please let me know if there is anything you need in the meantime.

Boster Scientific Support

Answered: 2017-11-30

Order DetailsPrice
PA1682

100μg

$370
PA1682-10ug

10μg sample (liquid)

$99
PA1682-Biotin

100 μg Biotin conjugated

$570
PA1682-Cy3

100 μg Cy3 conjugated

$570
PA1682-Dylight488

100 μg Dylight488 conjugated

$570
PA1682-Dylight550

100 μg Dylight550 conjugated

$570
PA1682-Dylight594

100 μg Dylight594 conjugated

$570
PA1682-FITC

100 μg FITC conjugated

$570
PA1682-HRP

100 μg HRP conjugated

$570
PA1682-APC

100 μg APC conjugated

$670
PA1682-PE

100 μg PE conjugated

$670
PA1682-carrier-free

Carrier Free

$370

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