Anti-PTN12 PTPN12 Antibody

PTPN12 antibody

Boster Bio Anti-PTN12 PTPN12 Antibody catalog # A02762. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse.

Product Info Summary

SKU: A02762
Size: 100ul
Reactive Species: Human, Mouse
Host: Rabbit
Application: ELISA, WB

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Product Name

Anti-PTN12 PTPN12 Antibody

View all PTPN12 Antibodies

SKU/Catalog Number

A02762

Size

100ul

Form

Liquid

Description

Boster Bio Anti-PTN12 PTPN12 Antibody catalog # A02762. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-PTN12 PTPN12 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02762)

Host

Rabbit

Contents

Liquid form in PBS containing 50% glycerol,and 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Recombinant protein of human CHRNB2.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A02762 is reactive to PTPN12 in Human, Mouse

Applications

A02762 is guaranteed for ELISA, WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

88.106kDa

Background of PTPN12

AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.

Cheung P.C.F., Biochem. J. 346:659-669(2000).
Lang T.M., Genomics 70:258-263(2000).
Ota T., Nat. Genet. 36:40-45(2004).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB 1:500-2000 ELISA 1:5000-20000

Validation Images & Assay Conditions

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Gene/Protein Information For PTPN12 (Source: Uniprot.org, NCBI)

Gene Name

PTPN12

Full Name

Tyrosine-protein phosphatase non-receptor type 12

Weight

88.106kDa

Superfamily

protein-tyrosine phosphatase family

Alternative Names

protein tyrosine phosphatase, non-receptor type 12; Protein-tyrosine phosphatase G1; PTPG1tyrosine-protein phosphatase non-receptor type 12; PTP-PESTEC 3.1.3.48 PTPN12 PTP-PEST, PTPG1 protein tyrosine phosphatase non-receptor type 12 tyrosine-protein phosphatase non-receptor type 12|protein-tyrosine phosphatase G1

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on PTPN12, check out the PTPN12 Infographic

PTPN12 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for PTPN12: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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Order DetailsPrice
A02762-100ul

100ul

$380

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