Anti-DNA repair protein RAD50 RAD50 Antibody

RAD50 antibody

Boster Bio Anti-DNA repair protein RAD50 RAD50 Antibody (Catalog # A00347). Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Product Info Summary

SKU: A00347
Size: 100 µl
Reactive Species: Human, Mouse, Rat
Host: Rabbit
Application: WB

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Product Name

Anti-DNA repair protein RAD50 RAD50 Antibody

View all RAD50 Antibodies

SKU/Catalog Number

A00347

Size

100 µl

Form

Liquid

Description

Boster Bio Anti-DNA repair protein RAD50 RAD50 Antibody (Catalog # A00347). Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-DNA repair protein RAD50 RAD50 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00347)

Host

Rabbit

Contents

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from internal of human RAD50.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A00347 is reactive to RAD50 in Human, Mouse, Rat

Applications

A00347 is guaranteed for WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

153.892kDa

Background of RAD50

Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.

Dolganov G.M., Mol. Cell. Biol. 16:4832-4841(1996).
Kim K.K., Gene 235:59-67(1999).
Carney J.P., Cell 93:477-486(1998).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blotting: 1:500~1:3000

Validation Images & Assay Conditions

Gene/Protein Information For RAD50 (Source: Uniprot.org, NCBI)

Gene Name

RAD50

Full Name

DNA repair protein RAD50

Weight

153.892kDa

Superfamily

SMC family

Alternative Names

DNA repair protein RAD50; EC 3.6; EC 3.6.1.15; EC 3.6.3; EC 3.6.3.27; hRad50; NBSLD; RAD50 (S. cerevisiae) homolog; RAD50 homolog (S. cerevisiae); Rad50; RAD502; RAD50-2 RAD50 NBSLD2, hRad50, RAD50 RAD50 double strand break repair protein DNA repair protein RAD50|RAD50 homolog, double strand break repair protein

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on RAD50, check out the RAD50 Infographic

RAD50 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for RAD50: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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Order DetailsPrice
A00347-100uL

100uL

$360

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