Anti-SIRT1 Antibody Picoband™

Sirtuin 1/SIRT1 antibody

Boster Bio Anti-SIRT1 Antibody Picoband™ catalog # A00018-1. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. Cited in 3 publication(s).

Product Info Summary

SKU: A00018-1
Size: 100 μg/vial
Reactive Species: Human, Mouse, Rat
Host: Rabbit
Application: ELISA, Flow Cytometry, IF, IHC, ICC, WB

Product Name

Anti-SIRT1 Antibody Picoband™

View all Sirtuin 1/SIRT1 Antibodies

SKU/Catalog Number

A00018-1

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-SIRT1 Antibody Picoband™ catalog # A00018-1. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-SIRT1 Antibody Picoband™ (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00018-1)

Host

Rabbit

Contents

Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

E.coli-derived human SIRT1 recombinant protein (Position: Y142-H533).

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins.

Reactive Species

A00018-1 is reactive to SIRT1 in Human, Mouse, Rat

Applications

A00018-1 is guaranteed for ELISA, Flow Cytometry, IF, IHC, ICC, WB Boster Guarantee

Observed Molecular Weight

120 kDa

Calculated molecular weight

81.681kDa

Background of Sirtuin 1/SIRT1

Sirtuin 1, also known as SIR2L1 or SIRT1, is a protein that in humans is encoded by the SIRT1 gene. It is mapped to 10q21.3. Sirtuin 1 is a member of the sirtuin family of proteins, homologs of the Sir2 gene in S. cerevisiae. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. Sirtuin 1 is downregulated in cells that have high insulin resistance and inducing its expression increases insulin sensitivity, suggesting the molecule is associated with improving insulin sensitivity. Furthermore, Sirtuin 1 was shown to de-acetylate and affect the activity of both members of the PGC1-alpha/ERR-alpha complex, which are essential metabolic regulatory transcription factors.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Reconsitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blot, 0.25-0.5μg/ml, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, Mouse, Rat, By Heat
Immunocytochemistry/Immunofluorescence, 2μg/ml, Human
Flow Cytometry, 1-3μg/1x106 cells, Human
Direct ELISA, 0.1-0.5μg/ml, Human

Validation Images & Assay Conditions

Gene/Protein Information For SIRT1 (Source: Uniprot.org, NCBI)

Gene Name

SIRT1

Full Name

NAD-dependent protein deacetylase sirtuin-1

Weight

81.681kDa

Superfamily

sirtuin family

Alternative Names

EC 3.5.1; S. cerevisiae, homolog) 1; SIR2alpha; SIR2L1; SIR2-like protein 1; SIRT1; Sirtuin 1 SIRT1 SIR2, SIR2L1, SIR2alpha sirtuin 1 NAD-dependent protein deacetylase sirtuin-1|NAD-dependent protein deacylase sirtuin-1|SIR2-like protein 1|regulatory protein SIR2 homolog 1|sirtuin type 1

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on SIRT1, check out the SIRT1 Infographic

SIRT1 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for SIRT1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

Hello CJ!

A00018-1 has been cited in 3 publications:

*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.

Resveratrol suppresses hyperoxia-induced nucleocytoplasmic shuttling of SIRT1 and ROS production in PBMC from preterm infants in vitro

Dietary restriction reduces blood lipids and ameliorates liver function of mice with hyperlipidemia

Ying Hz, Liu Yh, Yu B, Wang Zy, Zang Jn, Yu Ch. Food Chem Toxicol. 2013 Feb;52:53-60. Doi: 10.1016/J.Fct.2012.10.030. Epub 2012 Nov 2. Dietary Quercetin Ameliorates Nonalcoholic Steatohepatitis Induced By A High-Fat Diet In Gerbils.

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Order DetailsPrice
A00018-1

100μg

$370
A00018-1-10ug

10μg sample (liquid)

$99
A00018-1-Biotin

100 μg Biotin conjugated

$570
A00018-1-Cy3

100 μg Cy3 conjugated

$570
A00018-1-Dylight488

100 μg Dylight488 conjugated

$570
A00018-1-Dylight550

100 μg Dylight550 conjugated

$570
A00018-1-Dylight594

100 μg Dylight594 conjugated

$570
A00018-1-FITC

100 μg FITC conjugated

$570
A00018-1-HRP

100 μg HRP conjugated

$570
A00018-1-APC

100 μg APC conjugated

$670
A00018-1-PE

100 μg PE conjugated

$670
A00018-1-carrier-free

Carrier Free

$370

More conjugates/formats

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A00018-1
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$370.00

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