Rabbit IgG polyclonal antibody for Suppressor of cytokine signaling 2(SOCS2) detection. Tested with WB in Human;Mouse;Rat.
Anti-SOCS2 Antibody Info At A Glance
|Reactivity:||Human, Mouse, Rat|
|Product Name||Anti-SOCS2 Antibody
See all SOCS-2 primary antibodies, ELISA kits and proteins
|Storage & Handling||At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.|
|Description||Polyclonal antibody for SOCS-2/SOCS2 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: WB. Reactive species: Human. SOCS-2/SOCS2 information: Molecular Weight: 22172 MW; Tissue Specificity: High expression in heart, placenta, lung, kidney and prostate.|
|Cite This Product||Anti-SOCS2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1383)|
|Similar Products From
|Anti-SOCS2 Antibody may replace the following items: sc 7007|sc 7007 R|sc 7008|sc 9022.|
|Reactivity/Species||Human, Mouse, Rat|
*This antibody is predicted to react with the above species based on antigen sequence similarities. Our Boster Guarantee covers the use of this product with the above species.
*Our Boster Guarantee covers the use of this product in the above tested applications.
*Innovating Scientists reward: if you test this antibody on a species or application not listed above and share with us your results, we will provide you a full credit to purchase Boster products.
|Related Products||Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.
*Blocking peptide can be purchased at $50. Contact us for more information.
**Boster also offers various secondary antibodies for Immunoflourescecne and IHC. Take advantage of the buy 1 primary antibody get 1 secondary antibody for free promotion all year round.
|Immunogen||A synthetic peptide corresponding to a sequence at the C-terminus of human SOCS2(181-198aa LPLPTRLKDYLEEYKFQV), identical to the related mouse and rat sequences.|
|Cross Reactivity||No cross reactivity with other proteins|
Gene/Protein Basic Information For SOCS2 (Source: Uniprot.org, NCBI)
|NCBI Gene Id||8835|
|Species Of This Entry||Human|
|Protein Name||Suppressor of cytokine signaling 2|
|Alternative Names||SOCS-2|CIS2; CIS2CIS-2; Cish2; Cytokine-inducible SH2 protein 2; SOCS2; SOCS-2; SOCS-2STAT-induced STAT inhibitor 2; SSI2; SSI-2STAT induced STAT inhibitor-2; SSI2STAT-induced STAT inhibitor-2; STATI2; STATI2suppressor of cytokine signaling-2; suppressor of cytokine signaling 2|
|Post Tranlational Modifications||Phosphorylation; Methylation; Ubiquitination; Dephosphorylation; Demethylation; Reduction; Cleavage; Acetylation|
|Gene Location||12q22, on Chromasome 12, gene sequence: NC_000012.12 (93569849..93626236)|
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
Ontology For SOCS2 (Source: Uniprot.org, NCBI)
|Protein Function||SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.|
|Tissue Specificity||High expression in heart, placenta, lung, kidney and prostate.|
|Interacting Proteins||CUL5; ELOC; EPOR; KIT|
|Research Areas||Signal Transduction|
|Related Diseases||Janiceps; Malignant Neoplasms; Neoplasms; Inflammation; Leukemia; Carcinoma; Malignant Neoplasm Of Breast; Diabetes Mellitus; Mammary Neoplasms; Nervousness; Myeloid Leukemia; Cell Transformation, Neoplastic; Liver Carcinoma; Lymphoma; Insulin Resistance; Obesity; Kidney Diseases; Dwarfism; Hypertrophy; Hyperplasia|
|Related Pathways||Pathogenesis; Cell Proliferation; Cell Differentiation; Secretion; Immune Response; Methylation; Cell Activation; Cell Cycle; Lactation; Regeneration; T Cell Activation; Cell Growth; Aging; Cytokine Production; Regulation Of Growth; Neurogenesis; Cell Death; Gland Development; T Cell Differentiation; Insulin Secretion|
|Background||Suppressor of cytokine signaling 2 is a protein that in humans is encoded by the SOCS2 gene. This gene encodes a member of the STAT-induced STAT inhibitor(SSI), also known as suppressor of cytokine signalling(SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon-gamma(IFN-gamma). The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor 1 receptor(IGF1R), and thus is though to be involved in the regulation of IGF1R mediated cell signaling. Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control. By cytogenetic and radiation hybrid mapping, Yandava et al.(1999) mapped the SOCS2 gene to chromosome 12q21.3-q23.|
|Scientific References||PMID: 9266833 by Minamoto S., et al. Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3.|
PMID: 9344848 by Masuhara M., et al. Cloning and characterization of novel CIS family genes.
Our Boster Quality Guarantee for Anti-SOCS2 Antibody covers its use in the following applications.Western blot, 0.1-0.5μg/ml, Human, Mouse, Rat
*The recommended dilution ratios/concentrations are for reference only and optimal dilutions/concentrations should be determined by the end user.
All lanes: Anti SOCS2 (PA1383) at 0.5ug/ml
Lane 1: Rat Liver Tissue Lysate at 50ug
Lane 2: Rat Spleen Tissue Lysate at 50ug
Lane 3: MCF-7 Whole Cell Lysate at 40ug
Lane 4: HELA Whole Cell Lysate at 40ug
Lane 5: SMMC Whole Cell Lysate at 40ug
Lane 6: HT1080 Tissue Lysate at 50ug
Lane 7: Mouse Cardiac Muscle Tissue Lysate at 50ug
Lane 8: Mouse Liver Tissue Lysate at 50ug
Lane 9: Mouse Spleen Tissue Lysate at 50ug
Predicted bind size: 22KD
Observed bind size: 22KD
Boster provides comprehensive technical information for WB, IHC/IF/ICC, Flow Cytometry sample preparation protocols, assay protocols, troubleshooting tips and assay optimization tips.
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