Product Info Summary
SKU: | A01264 |
---|---|
Size: | 100μl |
Reactive Species: | Human, Mouse, Rat |
Host: | Rabbit |
Application: | IHC |
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Product info
Product Name
Anti-TGF beta3 TGFB3 Antibody
View all TGF-beta 3 Antibodies
SKU/Catalog Number
A01264
Size
100μl
Form
Liquid
Description
Boster Bio Anti-TGF beta3 TGFB3 Antibody catalog # A01264. Tested in IHC applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-TGF beta3 TGFB3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01264)
Host
Rabbit
Contents
PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Clonality
Polyclonal
Clone Number
8B3A11
Isotype
IgG
Immunogen
Synthetic peptide from human protein at AA range: 221-270.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
No cross reactivity with other proteins.
Reactive Species
A01264 is reactive to TGFB3 in Human, Mouse, Rat
Applications
A01264 is guaranteed for IHC Boster Guarantee
Observed Molecular Weight
39 kDa
Calculated molecular weight
47.328kDa
Background of TGF-beta 3
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by HDAC5 belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.
Doppler H, et al. (2005) J Biol Chem. 280(15):15013-15019.
McKinsey TA, et al. (2000) Nature. 408(6808): 106-111.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Innovating Scientists Reward
If you are the first to review this product, or if you have results for a special sample, species or application this product is not validated in, share your results with us and receive product credits you can use towards any Boster products! Applicable to all scientists worldwide.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
IHC-P 1:50-200
Validation Images & Assay Conditions
Click image to see more details
Immunohistochemical analysis of paraffin-embedded human-kidney, antibody was diluted at 1:200.
Click image to see more details
Immunohistochemical analysis of paraffin-embedded human-kidney, antibody was diluted at 1:200.
Protein Target Info & Infographic
Gene/Protein Information For TGFB3 (Source: Uniprot.org, NCBI)
Gene Name
TGFB3
Full Name
Transforming growth factor beta-3 proprotein
Weight
47.328kDa
Superfamily
TGF-beta family
Alternative Names
ARVD; ARVD1; FLJ16571; LDS5; RNHF; TGFB3; TGFbeta 3; TGF-beta 3; TGF-beta3; TGF-beta-3; transforming growth factor beta-3; transforming growth factor, beta 3 TGFB3 ARVD, ARVD1, LDS5, RNHF, TGF-beta3 transforming growth factor beta 3 transforming growth factor beta-3 proprotein|prepro-transforming growth factor beta-3
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on TGFB3, check out the TGFB3 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for TGFB3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-TGF beta3 TGFB3 Antibody (A01264)
Hello CJ!
A01264 has been cited in 1 publications:
*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.
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Customer Reviews
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Customer Q&As
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Find answers in Q&As, reviews.
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7 Customer Q&As for Anti-TGF beta3 TGFB3 Antibody
Question
I see that the anti-TGF beta3 antibody A01264 works with IHC, what is the protocol used to produce the result images on the product page?
Verified Customer
Verified customer
Asked: 2020-01-15
Answer
You can find protocols for IHC on the "support/technical resources" section of our navigation menu. If you have any further questions, please send an email to [email protected]
Boster Scientific Support
Answered: 2020-01-15
Question
I was wanting to use your anti-TGF beta3 antibody for IHC for human placenta on frozen tissues, but I want to know if it has been validated for this particular application. Has this antibody been validated and is this antibody a good choice for human placenta identification?
Verified Customer
Verified customer
Asked: 2019-11-19
Answer
You can see on the product datasheet, A01264 anti-TGF beta3 antibody has been validated for IHC on human, mouse, rat tissues. We have an innovator award program that if you test this antibody and show it works in human placenta in IHC-frozen, you can get your next antibody for free.
Boster Scientific Support
Answered: 2019-11-19
Question
We are currently using anti-TGF beta3 antibody A01264 for mouse tissue, and we are satisfied with the IHC results. The species of reactivity given in the datasheet says human, mouse, rat. Is it true that the antibody can work on horse tissues as well?
Verified Customer
Verified customer
Asked: 2019-08-13
Answer
The anti-TGF beta3 antibody (A01264) has not been tested for cross reactivity specifically with horse tissues, though there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in horse you can get your next antibody for free. Please contact me if I can help you with anything.
Boster Scientific Support
Answered: 2019-08-13
Question
Do you have a BSA free version of anti-TGF beta3 antibody A01264 available?
Verified Customer
Verified customer
Asked: 2019-05-13
Answer
I appreciate your recent telephone inquiry. I can confirm that some lots of this anti-TGF beta3 antibody A01264 are BSA free. For now, these lots are available and we can make a BSA free formula for you free of charge. It will take 3 extra days to prepare. If you require this antibody BSA free again in future, please do not hesitate to contact me and I will be pleased to check which lots we have in stock that are BSA free.
Boster Scientific Support
Answered: 2019-05-13
Question
Does anti-TGF beta3 antibody A01264 work on goat IHC with left coronary artery?
J. Gonzalez
Verified customer
Asked: 2019-04-11
Answer
Our lab technicians have not validated anti-TGF beta3 antibody A01264 on goat. You can run a BLAST between goat and the immunogen sequence of anti-TGF beta3 antibody A01264 to see if they may cross-react. If the sequence homology is close, then you can perform a pilot test. Keep in mind that since we have not validated goat samples, this use of the antibody is not covered by our guarantee. However we have an innovator award program that if you test this antibody and show it works in goat left coronary artery in IHC, you can get your next antibody for free.
Boster Scientific Support
Answered: 2019-04-11
Question
We want to test anti-TGF beta3 antibody A01264 on human placenta for research purposes, then I may be interested in using anti-TGF beta3 antibody A01264 for diagnostic purposes as well. Is the antibody suitable for diagnostic purposes?
Verified Customer
Verified customer
Asked: 2018-03-12
Answer
The products we sell, including anti-TGF beta3 antibody A01264, are only intended for research use. They would not be suitable for use in diagnostic work. If you have the means to develop a product into diagnostic use, and are interested in collaborating with us and develop our product into an IVD product, please contact us for more discussions.
Boster Scientific Support
Answered: 2018-03-12
Question
My question regarding product A01264, anti-TGF beta3 antibody. I was wondering if it would be possible to conjugate this antibody with biotin. I would need it to be without BSA or sodium azide. I am planning on using a buffer exchange of sodium azide with PBS only. Would there be problems for me to conjugate the antibody and store it in -20 degrees in small aliquots?
A. Wu
Verified customer
Asked: 2013-03-07
Answer
It is not recommended storing this antibody with PBS buffer only in -20 degrees. If you want to store it in -20 degrees it is best to add some cryoprotectant like glycerol. If you want carrier free A01264 anti-TGF beta3 antibody, we can provide it to you in a special formula with trehalose and/or glycerol. These molecules will not interfere with conjugation chemistry and provide a good level of protection for the antibody from degradation. Please be sure to specify this in your purchase order.
Boster Scientific Support
Answered: 2013-03-07