Anti-Thrombin Receptor/F2R Antibody

PAR1/Thrombin Receptor antibody

Boster Bio Anti-Thrombin Receptor/F2R Antibody catalog # RP1092. Tested in IHC, WB applications. This antibody reacts with Human.

Product Info Summary

SKU: RP1092
Size: 100 μg/vial
Reactive Species: Human
Host: Rabbit
Application: IHC, WB

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Product Name

Anti-Thrombin Receptor/F2R Antibody

View all PAR1/Thrombin Receptor Antibodies

SKU/Catalog Number

RP1092

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-Thrombin Receptor/F2R Antibody catalog # RP1092. Tested in IHC, WB applications. This antibody reacts with Human.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Thrombin Receptor/F2R Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # RP1092)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human Thrombin Receptor.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

RP1092 is reactive to F2R in Human

Applications

RP1092 is guaranteed for IHC, WB Boster Guarantee

Observed Molecular Weight

47 kDa

Calculated molecular weight

47.441kDa

Background of PAR1/Thrombin Receptor

Proteinase-activated receptor 1  (PAR1), also known as the coagulation factor II (thrombin) receptor, is a protein that in humans is encoded by the F2R gene. By fluorescence in situ hybridization, this gene is mapped to 5q13, confirming its presence as a single locus in the human genome. PAR1 is a G protein-coupled receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. The expression of PAR1 is both required and sufficient to promote growth and invasion of breast carcinoma cells in a xenograft mouse model. 

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Reconsitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, By Heat
Western blot, 0.1-0.5μg/ml, Human

Validation Images & Assay Conditions

Gene/Protein Information For F2R (Source: Uniprot.org, NCBI)

Gene Name

F2R

Full Name

Proteinase-activated receptor 1

Weight

47.441kDa

Superfamily

G-protein coupled receptor 1 family

Alternative Names

Cf2r; CF2RHTR; coagulation factor II (thrombin) receptor; Coagulation factor II receptor; F2R; HTR; PAR1; PAR1PAR-1protease-activated receptor 1; Protease-Activated Receptor 1; Thrombin receptor; ThrR; TRGPC; TRproteinase-activated receptor 1 F2R CF2R, HTR, PAR-1, PAR1, TR coagulation factor II thrombin receptor proteinase-activated receptor 1|protease-activated receptor 1

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on F2R, check out the F2R Infographic

F2R infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for F2R: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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7 Customer Q&As for Anti-Thrombin Receptor/F2R Antibody

Question

Has RP1092 been tested for other samples?

Verified customer

Asked: 2020-10-29

Answer

The Anti-Thrombin Receptor/F2R Antibody (RP1092) is only suitable for human samples.

Boster Scientific Support

Answered: 2020-10-30

Question

Does RP1092 anti-Thrombin Receptor/F2R antibody work on parafin embedded sections? If so, which fixation method do you recommend we use (PFA, paraformaldehyde, other)?

Verified Customer

Verified customer

Asked: 2020-04-30

Answer

It shows on the product datasheet, RP1092 anti-Thrombin Receptor/F2R antibody as been tested on IHC. It is best to use PFA for fixation because it has better tissue penetration ability. PFA needs to be prepared fresh before use. Long term stored PFA turns into formalin, as the PFA molecules congregate and become formalin.

Boster Scientific Support

Answered: 2020-04-30

Question

Would anti-Thrombin Receptor/F2R antibody RP1092 work on feline IHC with decidua?

Verified Customer

Verified customer

Asked: 2020-02-18

Answer

Our lab technicians have not validated anti-Thrombin Receptor/F2R antibody RP1092 on feline. You can run a BLAST between feline and the immunogen sequence of anti-Thrombin Receptor/F2R antibody RP1092 to see if they may cross-react. If the sequence homology is close, then you can perform a pilot test. Keep in mind that since we have not validated feline samples, this use of the antibody is not covered by our guarantee. However we have an innovator award program that if you test this antibody and show it works in feline decidua in IHC, you can get your next antibody for free.

Boster Scientific Support

Answered: 2020-02-18

Question

I was wanting to use your anti-Thrombin Receptor/F2R antibody for IHC for human decidua on frozen tissues, but I want to know if it has been tested for this particular application. Has this antibody been tested and is this antibody a good choice for human decidua identification?

Verified Customer

Verified customer

Asked: 2020-01-09

Answer

As indicated on the product datasheet, RP1092 anti-Thrombin Receptor/F2R antibody has been tested for IHC, WB on human tissues. We have an innovator award program that if you test this antibody and show it works in human decidua in IHC-frozen, you can get your next antibody for free.

Boster Scientific Support

Answered: 2020-01-09

Question

We are currently using anti-Thrombin Receptor/F2R antibody RP1092 for human tissue, and we are content with the IHC results. The species of reactivity given in the datasheet says human. Is it possible that the antibody can work on dog tissues as well?

Verified Customer

Verified customer

Asked: 2019-07-22

Answer

The anti-Thrombin Receptor/F2R antibody (RP1092) has not been tested for cross reactivity specifically with dog tissues, though there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in dog you can get your next antibody for free. Please contact me if I can help you with anything.

Boster Scientific Support

Answered: 2019-07-22

Question

I was wanting to use to test anti-Thrombin Receptor/F2R antibody RP1092 on human decidua for research purposes, then I may be interested in using anti-Thrombin Receptor/F2R antibody RP1092 for diagnostic purposes as well. Is the antibody suitable for diagnostic purposes?

N. Dhar

Verified customer

Asked: 2016-06-27

Answer

The products we sell, including anti-Thrombin Receptor/F2R antibody RP1092, are only intended for research use. They would not be suitable for use in diagnostic work. If you have the means to develop a product into diagnostic use, and are interested in collaborating with us and develop our product into an IVD product, please contact us for more discussions.

Boster Scientific Support

Answered: 2016-06-27

Question

Is this RP1092 anti-Thrombin Receptor/F2R antibody reactive to the isotypes of F2R?

N. Johnson

Verified customer

Asked: 2014-04-10

Answer

The immunogen of RP1092 anti-Thrombin Receptor/F2R antibody is A synthetic peptide corresponding to a sequence at the N-terminus of human Thrombin Receptor (46-82aa RNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQK). Could you tell me which isotype you are interested in so I can help see if the immunogen is part of this isotype?

Boster Scientific Support

Answered: 2014-04-10

Order DetailsPrice
RP1092

100μg

$370
RP1092-10ug

10μg sample (liquid)

$99
RP1092-Biotin

100 μg Biotin conjugated

$570
RP1092-Cy3

100 μg Cy3 conjugated

$570
RP1092-Dylight488

100 μg Dylight488 conjugated

$570
RP1092-Dylight550

100 μg Dylight550 conjugated

$570
RP1092-Dylight594

100 μg Dylight594 conjugated

$570
RP1092-FITC

100 μg FITC conjugated

$570
RP1092-HRP

100 μg HRP conjugated

$570
RP1092-APC

100 μg APC conjugated

$670
RP1092-PE

100 μg PE conjugated

$670
RP1092-carrier-free

Carrier Free

$370

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RP1092
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$370.00

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