Anti-Thymidylate Synthase TYMS Antibody

Thymidylate Synthase antibody

Boster Bio Anti-Thymidylate Synthase TYMS Antibody (Catalog # A04320). Tested in IHC, WB applications. This antibody reacts with Human.

Product Info Summary

SKU: A04320
Size: 2mL
Reactive Species: Human
Host: Sheep
Application: IHC, WB

Product Name

Anti-Thymidylate Synthase TYMS Antibody

View all Thymidylate Synthase Antibodies

SKU/Catalog Number

A04320

Size

2mL

Form

Lyophilized

Description

Boster Bio Anti-Thymidylate Synthase TYMS Antibody (Catalog # A04320). Tested in IHC, WB applications. This antibody reacts with Human.

Storage & Handling

Store vial at 4°C prior to restoration. For extended storage aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.

Cite This Product

Anti-Thymidylate Synthase TYMS Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A04320)

Host

Sheep

Contents

0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2, 0.01% (w/v) Sodium Azide

Clonality

Polyclonal

Isotype

Antiserum

Immunogen

This whole sheep serum was prepared by repeated immunizations with recombinant human Thymidylate Synthase (36 kDa) produced in E.coli.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A04320 is reactive to TYMS in Human

Applications

A04320 is guaranteed for IHC, WB Boster Guarantee

Observed Molecular Weight

19 kDa

Calculated molecular weight

35.716kDa

Background of Thymidylate Synthase

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript rTSalpha vary inversely when cell-growth progresses from late-log to plateau phase. Diseases associated with Thymidylate synthase include Rectal Neoplasm and Dihydropyrimidine Dehydrogenase Deficiency. Anti-Thymidylate synthase is useful for researchers interested in Circadian Rhythm, Metabolism and cell cycle research.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Reconsitution

Restore with deionized water (or equivalent) for reconstitution volume of 2.0 mL

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

ELISA: 1:10,000 - 1:50,000
IHC: 1:100
WB: 1:500- 1:2,000

Validation Images & Assay Conditions

Gene/Protein Information For TYMS (Source: Uniprot.org, NCBI)

Gene Name

TYMS

Full Name

Thymidylate synthase

Weight

35.716kDa

Superfamily

thymidylate synthase family

Alternative Names

EC 2.1.1.45; HsT422; MGC88736; thymidylate synthase; thymidylate synthetase; TMSTsase; TSase; TSHST422 TYMS HST422, TMS, TS thymidylate synthetase thymidylate synthase|TSase

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on TYMS, check out the TYMS Infographic

TYMS infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for TYMS: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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Order DetailsPrice
A04320

100 µg

$1544

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*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
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