Product Info Summary
SKU: | A15285 |
---|---|
Size: | 0.1 mg |
Reactive Species: | Human, Mouse, Rat |
Host: | Rabbit |
Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-Transmembrane protein 59-like TMEM59L Antibody
SKU/Catalog Number
A15285
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Transmembrane protein 59-like TMEM59L Antibody (Catalog # A15285). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
TMEM59L antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Transmembrane protein 59-like TMEM59L Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A15285)
Host
Rabbit
Contents
TMEM59L Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Clone Number
SK7
Isotype
IgG
Immunogen
TMEM59L antibody was raised against a 19 amino acid synthetic peptide near carboxy terminus of human TMEM59L. The immunogen is located within amino acids 220 - 270 of TMEM59L.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
Multiple isoforms of TMEM59L are known to exist. TMEM59L antibody is predicted to not cross-react TMEM59.
Reactive Species
A15285 is reactive to TMEM59L in Human, Mouse, Rat
Applications
A15285 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
37.619kDa
Background of TMEM59L
Processing of the amyloid precursor protein (APP) by two different proteases, called alpha- and beta-secretase, is a central regulatory event in the generation of the amyloid beta peptide (Abeta), which has a key role in Alzheimer disease (AD) pathogenesis. TMEM59L is a type I membrane glycoprotein that is expressed in the brain. A related protein, TMEM59, is a Golgi-localized protein that modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP and inhibits APP transport and shedding.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
TMEM59L antibody can be used for detection of TMEM59L by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of TMEM59L in rat heart tissue lysate with TMEM59L antibody at 1 μg/mL.
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Immunohistochemistry of TMEM59L in mouse brain tissue with TMEM59L antibody at 2.5 μg/mL.
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Immunofluorescence of TMEM59L in mouse brain tissue with TMEM59L antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For TMEM59L (Source: Uniprot.org, NCBI)
Gene Name
TMEM59L
Full Name
Transmembrane protein 59-like
Weight
37.619kDa
Superfamily
TMEM59 family
Alternative Names
BSMAPBrain-specific membrane-anchored protein; C19orf4; chromosome 19 open reading frame 4; transmembrane protein 59-like TMEM59L BSMAP, C19orf4 transmembrane protein 59 like transmembrane protein 59-like|brain-specific membrane-anchored protein
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on TMEM59L, check out the TMEM59L Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for TMEM59L: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Transmembrane protein 59-like TMEM59L Antibody (A15285)
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No publications found for A15285
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