Anti-TRIM21 Antibody

TRIM21/SSA1 antibody

Boster Bio Anti-TRIM21 Antibody (Catalog # A02079). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.

Product Info Summary

SKU: A02079
Size: 0.1 mg
Reactive Species: Human
Host: Rabbit
Application: ELISA, IF, IHC-P, WB

Product Name

Anti-TRIM21 Antibody

View all TRIM21/SSA1 Antibodies

SKU/Catalog Number

A02079

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-TRIM21 Antibody (Catalog # A02079). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.

Storage & Handling

TRIM21 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Cite This Product

Anti-TRIM21 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02079)

Host

Rabbit

Contents

TRIM21 Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Clone Number

SK7

Isotype

IgG

Immunogen

Anti-TRIM21 antibody was raised against a peptide corresponding to 16 amino acids near the center of human TRIM21. The immunogen is located within amino acids 290-340 of TRIM21.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

TRIM21 antibody is human specific. This antibody is predicted to not cross-react with TRIM6.

Reactive Species

A02079 is reactive to TRIM21 in Human

Applications

A02079 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee

Observed Molecular Weight

68 kDa

Calculated molecular weight

54.17kDa

Background of TRIM21/SSA1

TRIM21, a member of the tripartite motif (TRIM) family, is a part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus (1). RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus (2). TRIM21 also acts as a cytosolic antibody receptor; detection of intracellular antibodies activate immune signaling by stimulating the transcription factor pathways of NF-kappaB, AP-1, IRF3, IRF5, and IRF7, resulting in the production of proinflammatory cytokines and the induction of an antiviral state (3).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB: 0.5-2 μg/mL; IHC: 5 μg/mL; IF: 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples; Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

Gene/Protein Information For TRIM21 (Source: Uniprot.org, NCBI)

Gene Name

TRIM21

Full Name

E3 ubiquitin-protein ligase TRIM21

Weight

54.17kDa

Superfamily

TRIM/RBCC family

Alternative Names

52 kDa ribonucleoprotein autoantigen Ro/SS-A; 52 kDa Ro/SSA; E3 ubiquitin-protein ligase TRIM21; EC 6.3.2.-; rhTRIM21; RNF81; RNF81RING finger protein 81; ro(SS-A); Ro52; RO52SS-A; Sicca syndrome antigen A; Sjoegren syndrome type A antigen; Sjogren syndrome antigen A1 (52kDa, ribonucleoprotein autoantigen SS-A/Ro); SSA1; SSA1SSA; TRIM21; tripartite motif containing 21,52 kDa Ro protein; tripartite motif-containing 21; Tripartite motif-containing protein 21 TRIM21 RNF81, RO52, Ro/SSA, SSA, SSA1 tripartite motif containing 21 E3 ubiquitin-protein ligase TRIM21|52 kDa Ro protein|52 kDa ribonucleoprotein autoantigen Ro/SS-A|RING finger protein 81|RING-type E3 ubiquitin transferase TRIM21|Ro/SSA 52kDa|SS-A|Sicca syndrome antigen A|Sjogren syndrome antigen A1 (52kDa, ribonucleoprotein autoantigen SS-A/Ro)|ro(SS-A)|sjoegren syndrome type A antigen|tripartite motif-containing protein 21

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on TRIM21, check out the TRIM21 Infographic

TRIM21 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for TRIM21: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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Order DetailsPrice
A02079-0.1 mg

0.1 mg

$449

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