Product Info Summary
SKU: | A01591-2 |
---|---|
Size: | 100ul |
Reactive Species: | Human, Mouse, Rat |
Host: | Rabbit |
Application: | Flow Cytometry, IHC, WB |
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Product info
Product Name
Anti-Tropomyosin 1 TPM1 Antibody
View all Tropomyosin-1 Antibodies
SKU/Catalog Number
A01591-2
Size
100ul
Form
Liquid
Description
Boster Bio Anti-Tropomyosin 1 TPM1 Antibody catalog # A01591-2. Tested in WB,IHC,Flow Cytometry applications. This antibody reacts with Human,Mouse,Rat.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Tropomyosin 1 TPM1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01591-2)
Host
Rabbit
Contents
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from internal of human PNN.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
No cross reactivity with other proteins.
Reactive Species
A01591-2 is reactive to TPM1 in Human, Mouse, Rat
Applications
A01591-2 is guaranteed for Flow Cytometry, IHC, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
32.709kDa
Background of Tropomyosin-1
Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Component of the PSAP complex which binds RNA in a sequence-independent manner and is proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma.
Ouyang P., J. Cell Biol. 135:1027-1042(1996).
Degen W.G.J., Biochim. Biophys. Acta 1444-384-394(1999).
Shi Y., Oncogene 19:289-297(2000).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB: 1:500-1:2,000
IHC: 1:50-1:200
FC: 1:50-1:100
Validation Images & Assay Conditions
Click image to see more details
Figure 2. Immunohistochemistry validation of TPM1 using Anti-Tropomyosin 1 TPM1 Antibody (A01591-2).
Immunohistochemical analysis of paraffin-embedded rat smooth muscle tissue using anti-Tropomyosin 1 antibody. Counter stained with hematoxylin.For more protocol information of IHC
Click image to see more details
Figure 1. Western blotting validation for Anti-Tropomyosin 1 TPM1 Antibody A01591-2
Western blot analysis of Tropomyosin 1 on rat heart tissue using anti-Tropomyosin 1 antibody at 1/1Protein Target Info & Infographic
Gene/Protein Information For TPM1 (Source: Uniprot.org, NCBI)
Gene Name
TPM1
Full Name
Tropomyosin alpha-1 chain
Weight
32.709kDa
Superfamily
tropomyosin family
Alternative Names
alpha tropomyosin; alpha-tropomyosin; C15orf13; cardiomyopathy, hypertrophic 3; chromosome 15 open reading frame 13; CMD1Y; CMH3; HTM-alpha; sarcomeric tropomyosin kappa; TMSA; tropomyosin 1 (alpha) isoform 1; tropomyosin 1 (alpha) isoform 2; tropomyosin 1 (alpha) isoform 3; tropomyosin 1 (alpha) isoform 4; tropomyosin 1 (alpha) isoform 5; tropomyosin 1 (alpha) isoform 6; tropomyosin 1 (alpha) isoform 7; tropomyosin 1 (alpha); tropomyosin alpha-1 chain; tropomyosin-1 TPM1 C15orf13, CMD1Y, CMH3, HEL-S-265, HTM-alpha, LVNC9, TMSA tropomyosin 1 tropomyosin alpha-1 chain|cardiomyopathy, hypertrophic 3|epididymis secretory protein Li 265|sarcomeric tropomyosin kappa
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on TPM1, check out the TPM1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for TPM1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Tropomyosin 1 TPM1 Antibody (A01591-2)
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No publications found for A01591-2
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