Anti-TSC22 domain family protein 3 TSC22D3 Antibody

GilZ antibody

Boster Bio Anti-TSC22 domain family protein 3 TSC22D3 Antibody catalog # A03078-1. Tested in WB applications. This antibody reacts with Human.

Product Info Summary

SKU: A03078-1
Size: 100ul
Reactive Species: Human
Host: Rabbit
Application: WB

Product Name

Anti-TSC22 domain family protein 3 TSC22D3 Antibody

View all GilZ Antibodies

SKU/Catalog Number

A03078-1

Size

100ul

Form

Liquid

Description

Boster Bio Anti-TSC22 domain family protein 3 TSC22D3 Antibody catalog # A03078-1. Tested in WB applications. This antibody reacts with Human.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-TSC22 domain family protein 3 TSC22D3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A03078-1)

Host

Rabbit

Contents

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from human ADAM9 protein.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A03078-1 is reactive to TSC22D3 in Human

Applications

A03078-1 is guaranteed for WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

14.81kDa

Background of GilZ

RRM2B/p53-R2, or p53-inducible ribonucleotide reductase small subunit 2-like protein, is a member of a broad superfamily of ferritin-like di-iron-carboxylate proteins. The RRM2B protein is an enzyme that catalyzes the conversion of ribonucleotides to deoxyribonucleotides that are essential for DNA synthesis, and is found in all eukaryotes. RRM2B plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. It supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. It contains an iron-tyrosyl free radical center required for catalysis, and forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage. It is a heterotetramer with a large (RRM1) subunit, and interacts with p53/TP53. The interaction with RRM1 occurs in response to DNA damage and results in its translocation from cytoplasm to nucleus. It is widely expressed at a high level in skeletal muscle and at a weak level in thymus, and expressed in epithelial dysplasias and squamous cell carcinoma. Defects in RRM2B are the cause of encephalomyopathic mitochondrial depletion syndrome with renal tubulopathy (EMDSRT). Mitochondrial DNA depletion syndrome (MDS) is a clinically heterogeneous group of disorders characterized by a reduction in mitochondrial DNA (mtDNA) copy number. The encephalomyopathic form with renal tubulopathy is presented with various combinations of hypotonia, tubulopathy, seizures, respiratory distress, diarrhea, and lactic acidosis.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB: 1:500-1:2000

Validation Images & Assay Conditions

There are currently no images for this product. We are working on uploading them please check back shortly or contact us to expedite our upload process for this antibody.

Gene/Protein Information For TSC22D3 (Source: Uniprot.org, NCBI)

Gene Name

TSC22D3

Full Name

TSC22 domain family protein 3

Weight

14.81kDa

Superfamily

TSC-22/Dip/Bun family

Alternative Names

Delta sleep-inducing peptide immunoreactor; DSIP-immunoreactive leucine zipper protein; DSIP-immunoreactive peptide; GILZDKFZp313A1123; Glucocorticoid-induced leucine zipper protein; Protein DIP; TSC22 domain family protein 3; TSC22 domain family, member 3; TSC-22 related protein; TSC-22-like protein; TSC-22-related protein; TSC-22Rimmunoreactor TSC22D3 DIP, DSIPI, GILZ, TSC-22R TSC22 domain family member 3 TSC22 domain family protein 3|DSIP-immunoreactive leucine zipper protein|DSIP-immunoreactive peptide|TSC-22 related protein|TSC-22-like protein|delta sleep-inducing peptide immunoreactor|glucocorticoid-induced leucine zipper protein

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on TSC22D3, check out the TSC22D3 Infographic

TSC22D3 infographic

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In this infographic, you will see the following information for TSC22D3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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Order DetailsPrice
A03078-1-100ul

100ul

$405

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