Boster Bio Life Science Blog

  1. Research Spotlight - December 2021

    In our last edition of Research Spotlight this year, we're happy to feature 10 recent publications from scientists whom Boster has served.

    Among the studies, scientists investigate the mechanisms of m6a reader for colorectal cancer, the anti-metastatic roles of dsRNA mimics, and the effects of USP12 on breast cancer angiogenesis.

    In addition, scientists explore Vitamin D3's antioxidative stress ability as well as the lungfish cocoon's antimicrobial functions. Researchers also develop pitavastatin-loaded multilayer films that enhance osseointegration of metal implants.

    Scroll down to find out more about these discoveries!

    Vitamin D3 Protects Mice from Diquat-Induced Oxidative Stress through the NF-κB/Nrf2/HO-1 Signaling Pathway

    Authors: Zhang, H., Liu, Y., Fang, X., Gu, L., Luo, C., Chen, L., Wang, Q.
    Journal: Oxidative Medicine and Cellular Longevity

    Vitamin D3, as an indispensable and fat-soluble micronutrient, plays an important role in the health of humans and animals. At

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    Research Spotlight - December 2021
  2. Research Spotlight - July 2021

    In the July edition of Research Spotlight, we hand-picked a range of scientific publications that investigate several new approaches to control the development of chronic and morbid diseases without systemic side effects.

    Among the studies, researchers discuss how modulations of IL-1β-primed ERCs, IL-23, Lnc-408, and LncRNA CERS6-AS1 levels could alleviate the pathological damages of ulcerative colitis, breast cancer, and pancreatic cancer respectively. Associations between prenatal acrylamide exposure with decreased fetal growth are also further explored.

    Scroll down to learn about new drug delivery platforms and therapies, and discover more about the immune response towards diseases.

    IL-1β Pre-Stimulation Enhances the Therapeutic Effects of Endometrial Regenerative Cells on Experimental Colitis

    Authors: Yu, D., Zhao, Y., Wang, H., Kong, D., Jin, W., Hu, Y., Qin, Y…
    Journal: Stem Cell Research & Therapy

    Background: Ulcerative colitis (UC) is a chronic, relapsing, and non-specific inflammatory bowel disease, and the current treatment strategies were mainly used to relieve symptoms or for maintenance. Endometrial regenerative cells (ERCs) are mesenchymal-like stromal cells and have been demonstrated to alleviate multiple immune...

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    Cited Boster Product(s): Anti-Mannose Receptor/MRC1 Picoband™ Antibody (A02285-2); Mouse IFN Gamma ELISA Kit PicoKine™ (EK0375); Mouse IL-17 ELISA Kit PicoKine™ (EK0431); Mouse TNF Alpha ELISA Kit PicoKine™ (EK0527); Mouse IL-6 ELISA Kit PicoKine™ (EK0411); Mouse IL-4 ELISA Kit PicoKine™ (EK0405); Mouse IL-10 ELISA Kit PicoKine™ (EK0417)

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    Intravenous Delivery of Lung-Targeted Nanofibers for Pulmonary Hypertension in Mice

    Authors: Marulanda, K., Mercel, A., Gillis, D.C., Sun, K., Gambarian, M…
    Journal: Advanced Healthcare Materials

    Pulmonary hypertension is a highly morbid disease with no cure. Available treatments are limited by systemic adverse effects

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    Research Spotlight - July 2021
  3. Research Spotlight - May 2021

    This month, we share some of the latest research studies that explore the underlying mechanisms in disease progressions investigated by scientists whom Boster has served.

    Our May edition of Research Spotlight includes a mix of topics about myopia, breast cancer, DNA damage, and inflammatory response progressions. Find out more about the essential roles of several compounds and novel treatments in modulating the responses of signalling pathways.

    Scroll down to learn more about these new scientific discoveries.

    Aberrant TGF-β1 Signaling Activation by MAF Underlies Pathological Lens Growth in High Myopia

    Authors: Zhu, X., Du, Y., Li, D., Xu, J., Wu, Q., He, W., Zhang, K., Zhu, J…
    Journal: Nature Communications

    High myopia is a leading cause of blindness worldwide. Myopia progression may lead to pathological changes of lens and affect the outcome of lens surgery, but the underlying mechanism remains unclear. Here, we find an increased lens size in highly myopic eyes associated with up-regulation of β/γ-crystallin expressions. Similar findings are replicated in two independent...

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    Cited Boster Product(s): Human TGF Beta 1 ELISA Kit PicoKine™ (EK0513)

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    Cu-Induced Spermatogenesis Disease is Related to Oxidative stress-Mediated Germ Cell Apoptosis and DNA Damage

    Authors: Guo, H., Ouyang, Y., Wang, J., Cui, H., Deng, H., Zhong, X., Jian, Z…
    Journal: Journal of Hazardous Materials

    Copper is considered as an indispensable trace element for living organisms. However, over-exposure to Cu can lead to adverse health effects on human. In this study, CuSO4 decreased sperm concentration and motility, increased sperm malformation rate. Concurrently, testicular damage including testicular histopathological aberrations...

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    Cited Boster Product(s): Goat Anti-Mouse IgG (H+L) Secondary Antibody, Biotin Conjugated (BA1001)

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    Light-Induced Dynamic RGD Pattern for Sequential Modulation of Macrophage Phenotypes

    Authors: Luo, Y., Zheng, X., Yuan, P., Ye, X., Ma, L.
    Journal: Bioactive Materials

    Due to the critical roles of macrophage in immune response and tissue repair, harnessing macrophage phenotypes dynamically to match the tissue healing process on demand attracted many attentions. Although there have developed many advanced platforms with dynamic features for cell manipulation, few studies have designed a dynamic...

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    Cited Boster Product(s): Mouse TNF Alpha/Tumor Necrosis Factor ELISA Kit PicoKine™ (EK0527); Mouse IL-1 Beta/IL-1F2/IL1B ELISA Kit PicoKine™ (EK0394); Mouse IL-10/Interleukin-10 ELISA Kit PicoKine™ (EK0417); Mouse TGF Beta 1 ELISA Kit PicoKine™ (EK0515)

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    VRK2 is Involved in the Innate Antiviral Response by Promoting Mitostress-Induced mtDNA Release

    Authors: He, W.R., Cao, L.B., Yang, Y.L., Hua, D., Hu, M.M., Shu, H.B.
    Journal: Cellular & Molecular Immunology

    Mitochondrial stress (mitostress) triggered by viral infection or mitochondrial dysfunction causes the release of mitochondrial DNA (mtDNA) into the cytosol and activates the cGAS-mediated innate immune response. The regulation of mtDNA release upon mitostress remains uncharacterized. Here, we identified mitochondria-associated...

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    Cited Boster Product(s): Mouse CXCL10/IP-10 ELISA Kit PicoKine™ (EK0736)

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    LncRNA SNHG6 Promotes G1/S-Phase Transition in Hepatocellular Carcinoma by Impairing miR-204-5p-Mediated Inhibition of E2F1

    Authors: Chen, K., Hou, Y., Liao, R., Li, Y., Yang, H., Gong, J.
    Journal: Oncogene

    Emerging evidence suggests that long noncoding RNAs (lncRNAs) function as competitive endogenous RNA (ceRNA) targeting proteins and genes; however, the role of lncRNAs in hepatocellular carcinoma (HCC) is not well understood. We investigated the mechanism by which lncRNA SNHG6 promotes the development of HCC. RT-qPCR revealed...

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    Cited Boster Product(s): RIPA Lysis Buffer (AR0105-100)

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    Exposure to Constant Light Impairs Cognition with FTO Inhibition and m6A-Dependent TrκB Repression in Mouse Hippocampus

    Authors: Yang, Y., Feng, Y., Hu, Y., Liu, J., Shi, H., Zhao, R.
    Journal: Environmental Pollution

    N6-methyladenosine (m6A) mRNA methylation plays a role in various brain functions. Exposure to chronic constant light (CCL) has been reported to impair cognition, yet whether the underlying mechanism involves m6A remains unknown. In this study, mice exposed to CCL for 3 weeks show impaired cognitive behavior, which was associated...

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    Cited Boster Product(s): HRP Conjugated Goat Anti-Mouse IgG SABC Kit (SA1021); HRP Conjugated Goat Anti-Rabbit IgG SABC Kit (SA1022)

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    Increased Telomerase Activity in Major Depressive Disorder with Melancholic Features: Possible Role of Pro-Inflammatory Cytokines and the Brain-Derived Neurotrophic Factor

    Authors: Çavuşoğlu, P.B., İscan, E., Güneş, A., Atabey, N., Alkın, T.
    Journal: Brain, Behavior, & Immunity - Health

    The biological mechanisms responsible for depression symptoms are not yet understood. For this reason, it is important to reveal the etiopathogenetic mechanisms in this disease. This study aims to compare the levels of pro-inflammatory cytokines, Brain-Derived Neurotrophic Factor (BDNF), and telomerase activity in patients with major...

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    Cited Boster Product(s): Human IL-6

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    Research Spotlight - May 2021
  4. Research Spotlight - March 2021

    In our March edition of Research Spotlight, we present 10 latest research papers from scientists whom Boster has served.

    Scientists explore the roles of various pathways associated with tumor development, and how they may emerge as new therapeutic targets for tumor metastasis. Several research studies also reveal the active role of gut microbiota in immunity and disease progressions as well as the effect of several compounds on the functionality and ecology of gut microbiome.

    Take a look below to learn more about these new research findings.

    Fecal Microbiota Transplantation in HIV: A Pilot Placebo-Controlled Study

    Authors: Serrano-Villar, S., Talavera-Rodríguez, A., Gosalbes, M.J., Madrid, N...
    Journal: Nature Communications

    Changes in the microbiota have been linked to persistent inflammation during treated HIV infection. In this pilot double-blind study, we study 30 HIV-infected subjects on antiretroviral therapy (ART) with a CD4/CD8 ratio less than 1 randomized to either weekly fecal microbiota capsules or placebo for 8 weeks. Stool donors were rationally...

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    Cited Boster Product(s): Human LB

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    Research Spotlight - March 2021
  5. Research Spotlight - October 2020

    The October edition of Research Spotlight features 10 recent research discoveries from scientists whom Boster has served.

    This month’s research publications examine treatments and mechanisms for cancers such as breast cancer, colitis-associated cancer, and ovarian cancer. Scientists also propose stem cell derived biomimetic vesicles for versatile and effective targeted delivery. In addition, researchers investigate how dihydroartemisinin (DHA) can ameliorate psoriatic skin inflammation.

    Scroll down to learn more about these new scientific discoveries.

    GSH Depletion Liposome Adjuvant for Augmenting the Photothermal Immunotherapy of Breast Cancer

    Authors: Zhou, Z., Wu, H., Yang, R., Xu, A., Zhang, Q., Dong, J., Qian, C., & Sun, M.
    Journal: Science Advances

    The high redox level of tumor microenvironment inhibits the oxidation treatment and the immune response. Here, we innovatively develop maleimide liposome (ML) adjuvants to promote immunogenic cell death (ICD) induction and dendritic cells (DCs) maturation by glutathione (GSH) depletion for augmenting the photothermal immunotherapy...

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    Research Spotlight - October 2020
  6. Research Spotlight – July 2020

    In our July edition of Research Spotlight, we feature 10 recently published research papers from scientists whom Boster has served.

    This month’s research publications examine different types of cancers, including ovarian cancer, breast cancer, colorectal cancer, etc. Scientists also delve into other research fields, such as intervertebral disc (IVD) degeneration, wound healing, and type 2 diabetes.

    Scroll down to learn more about these new scientific discoveries.

    Accumulation of advanced glycation end products (AGEs) is associated with the severity of aortic stenosis in patients with concomitant type 2 diabetes

    Authors: Kopytek, M., Ząbczyk, M., Mazur, P., Undas, A., & Natorska, J.
    Journal: Cardiovascular Diabetology

    Accumulation of advanced glycation end products (AGEs) leads to chronic glycation of proteins and tissue damage, particularly in patients with diabetes mellitus (DM). We aimed to evaluate whether increased accumulation of AGEs in patients with aortic stenosis (AS) and concomitant type 2 diabetes (DM) is associated with AS severity...

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    Cited Boster Product(s): Human Rage ELISA Kit PicoKine™ (EK0827)

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    Antitumor effect of a WEE1 inhibitor and potentiation of olaparib sensitivity by DNA damage response modulation in triple-negative breast cancer

    Authors: Ha, D.H., Min, A., Kim, S., Jang, H., Kim, S.H., Kim, H.J., Ryu, H.S, Ku, J.L...
    Journal: Scientific Reports

    Due to its regulation of CDK1/2 phosphorylation, WEE1 plays essentially roles in the regulations of G2/M checkpoint and DNA damage response (DDR). WEE1 inhibition can increase genomic instability by inducing replication stress and G2/M checkpoint inactivation, which result in increased cellular sensitivity to DNA damaging agents...

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    Cited Boster Product(s): Anti-Phospho-Cdc2 (Tyr15) CDK1 Antibody (P00209)

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    Cortistatin protects against intervertebral disc degeneration through targeting mitochondrial ROS-dependent NLRP3 inflammasome activation

    Authors: Zhao, Y., Qiu, C., Wang, W., Peng, J., Cheng, X., Shangguan, Y., Xu, M., Li, J...
    Journal: Theranostics

    Background: Intervertebral disc (IVD) degeneration is a common degenerative disease that can lead to collapse or herniation of the nucleus pulposus (NP) and result in radiculopathy in patients. Methods: NP tissue and cells were isolated from patients and mice, and the expression profile of cortistatin (CST) was analysed. In addition...

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    Research Spotlight – July 2020
  7. Research Spotlight – February 2020

    At Bosterbio, our customers’ research is our priority. Our mission is to help customers achieve their research goals so that they can stay on the cutting edge of research.

    This February, we’d like to feature a selected number of recently published research from the scientists whom Boster has served.

    Scroll down to see 10 research discoveries from different fields.

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    Research Spotlight – February 2020