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Boster Bio Life Science Blog
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The June issue of Research Spotlight highlights research advancements from scientists whom we have served.
Read about new studies outlining potential treatments to promote tissue repair and regeneration. For example, one study demonstrated the significance of EE for cardiac repair.
Scientists also investigated the promising roles of ROS-scavenging hydrogel, responsive Mn3O4 nanoplatform, and a novel 3D-printed porous bioactive ceramic scaffold for spinal cord injury, gastric cancer, and bone injury, respectively.
Other papers uncovered the molecular mechanisms of SIRT1, Neat1, cathepsin B/NLRP3, and FASN in different diseases and cancer.
Scroll down to learn more about these 10 research discoveries.
Environmental Eustress Improves Postinfarction Cardiac Repair via Enhancing Cardiac Macrophage Survival
Authors: Bai, P.Y., Chen, S.Q., Jia, D.L., Pan, L.H., Liu, C.B., Luo, J.L., Yang, Y…
Journal: Science AdvancesMacrophages play a vital role in cardiac repair following myocardial infarction (MI). An enriched environment (EE) is involved in the regulation of macrophage-related activities and disease progression; however, whether EE affects the phenotype and function of macrophages to improve postinfarction cardiac repair remains unknown...
Cited Boster Product(s): Mouse BDNF ELISA Kit PicoKine® (EK0309)
...Catalpol Enhances Random-Pattern Skin Flap Survival by Activating SIRT1-Mediated Enhancement of Autophagy
Authors: Jiang, R.H., Dong, C.J., Chen, Z.L., Cheng, S., Yang, J.X., Gao, W.Y.
Journal: Oxidative Medicine and Cellular LongevityRandom-pattern skin flap necrosis limits its application in the clinic. It is still a challenge for plastic surgeons. Catalpol is an effective ingredient extracted from Rehmannia glutinosa, which is reported to promote angiogenesis and protect against ischemic cerebral disease. The aim of our experiment is to assess whether catalpol...
Cited Boster Product(s): Anti-VE-Cadherin-5 Cdh5-Antibody Picoband™ (A02632-2)
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For this month’s Research Spotlight, we highlight 10 new research publications from scientists whom Boster has served.
In the field of cancer immunotherapy, data from two studies point toward the anti-lymphoma and anti-bladder cancer effects exerted by ADAM10 and iDAMP inhibitors respectively. Additionally, scientists present the promising potential of CEACAM 5, PCL22-186, and lncSLCO1C1 as new biomarkers for predicting cancer cells’ radiosensitivity, cancer progression, and resistance...
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Today is World Cancer Day. Each year, organizations and people from around the world unite on February 4th to raise awareness about cancer.
According to the American Cancer Society, cancer mortality had dropped 32% from 1991 to 2019. This decline is mostly attributed to decreases in smoking and advancements in early cancer detection and treatment.
Despite this reduction in cancer mortality, cancer remains as a major public health problem worldwide. Globally, 1 out of 6 deaths...
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Our August edition of Research Spotlight presents 10 recent publications from scientists whom Boster has served.
In this month’s edition, research studies delve into the behavioral and cognitive parts of the brain and investigate how various cytokine levels are associated with the progression of neurodegenerative disorders. A comprehensive evaluation of the efficacy and safety of using stem cell therapy for traumatic brain injury is also discussed.
Researchers explore additional...
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In the July edition of Research Spotlight, we hand-picked a range of scientific publications that investigate several new approaches to control the development of chronic and morbid diseases without systemic side effects.
Among the studies, researchers discuss how modulations of IL-1β-primed ERCs, IL-23, Lnc-408, and LncRNA CERS6-AS1 levels could alleviate the pathological damages of ulcerative colitis, breast cancer, and pancreatic cancer respectively. Associations between prenatal acrylamide exposure with decreased fetal growth are also further explored.
Scroll down to learn about new drug delivery platforms and therapies, and discover more about the immune response towards diseases.
IL-1β Pre-Stimulation Enhances the Therapeutic Effects of Endometrial Regenerative Cells on Experimental Colitis
Authors: Yu, D., Zhao, Y., Wang, H., Kong, D., Jin, W., Hu, Y., Qin, Y…
Journal: Stem Cell Research & TherapyBackground: Ulcerative colitis (UC) is a chronic, relapsing, and non-specific inflammatory bowel disease, and the current treatment strategies were mainly used to relieve symptoms or for maintenance. Endometrial regenerative cells (ERCs) are mesenchymal-like stromal cells and have been demonstrated to alleviate multiple immune...
Cited Boster Product(s): Anti-Mannose Receptor/MRC1 Picoband™ Antibody (A02285-2); Mouse IFN Gamma ELISA Kit PicoKine™ (EK0375); Mouse IL-17 ELISA Kit PicoKine™ (EK0431); Mouse TNF Alpha ELISA Kit PicoKine™ (EK0527); Mouse IL-6 ELISA Kit PicoKine™ (EK0411); Mouse IL-4 ELISA Kit PicoKine™ (EK0405); Mouse IL-10 ELISA Kit PicoKine™ (EK0417)
...Intravenous Delivery of Lung-Targeted Nanofibers for Pulmonary Hypertension in Mice
Authors: Marulanda, K., Mercel, A., Gillis, D.C., Sun, K., Gambarian, M…
Journal: Advanced Healthcare MaterialsPulmonary hypertension is a highly morbid disease with no cure. Available treatments are limited by systemic adverse effects
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Our June edition of Research Spotlight presents 10 recent research papers from scientists whom Boster has served.
In the selected studies, you will learn how the research community is developing more efficient ways for drug delivery, utilizing biomaterials in therapeutic treatments, exploring various pathological reactions, and many more.
Among the papers, scientists investigate how the apoptotic process can be used to load drugs for brain-targeted delivery with much higher efficiency...
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This month, we share some of the latest research studies that explore the underlying mechanisms in disease progressions investigated by scientists whom Boster has served.
Our May edition of Research Spotlight includes a mix of topics about myopia, breast cancer, DNA damage, and inflammatory response progressions. Find out more about the essential roles of several compounds and novel treatments in modulating the responses of signalling pathways.
Scroll down to learn more about these new scientific discoveries.
Aberrant TGF-β1 Signaling Activation by MAF Underlies Pathological Lens Growth in High Myopia
Authors: Zhu, X., Du, Y., Li, D., Xu, J., Wu, Q., He, W., Zhang, K., Zhu, J…
Journal: Nature CommunicationsHigh myopia is a leading cause of blindness worldwide. Myopia progression may lead to pathological changes of lens and affect the outcome of lens surgery, but the underlying mechanism remains unclear. Here, we find an increased lens size in highly myopic eyes associated with up-regulation of β/γ-crystallin expressions. Similar findings are replicated in two independent...
Cited Boster Product(s): Human TGF Beta 1 ELISA Kit PicoKine™ (EK0513)
Cu-Induced Spermatogenesis Disease is Related to Oxidative stress-Mediated Germ Cell Apoptosis and DNA Damage
Authors: Guo, H., Ouyang, Y., Wang, J., Cui, H., Deng, H., Zhong, X., Jian, Z…
Journal: Journal of Hazardous MaterialsCopper is considered as an indispensable trace element for living organisms. However, over-exposure to Cu can lead to adverse health effects on human. In this study, CuSO4 decreased sperm concentration and motility, increased sperm malformation rate. Concurrently, testicular damage including testicular histopathological aberrations...
Cited Boster Product(s): Goat Anti-Mouse IgG (H+L) Secondary Antibody, Biotin Conjugated (BA1001)
Light-Induced Dynamic RGD Pattern for Sequential Modulation of Macrophage Phenotypes
Authors: Luo, Y., Zheng, X., Yuan, P., Ye, X., Ma, L.
Journal: Bioactive MaterialsDue to the critical roles of macrophage in immune response and tissue repair, harnessing macrophage phenotypes dynamically to match the tissue healing process on demand attracted many attentions. Although there have developed many advanced platforms with dynamic features for cell manipulation, few studies have designed a dynamic...
Cited Boster Product(s): Mouse TNF Alpha/Tumor Necrosis Factor ELISA Kit PicoKine™ (EK0527); Mouse IL-1 Beta/IL-1F2/IL1B ELISA Kit PicoKine™ (EK0394); Mouse IL-10/Interleukin-10 ELISA Kit PicoKine™ (EK0417); Mouse TGF Beta 1 ELISA Kit PicoKine™ (EK0515)
VRK2 is Involved in the Innate Antiviral Response by Promoting Mitostress-Induced mtDNA Release
Authors: He, W.R., Cao, L.B., Yang, Y.L., Hua, D., Hu, M.M., Shu, H.B.
Journal: Cellular & Molecular ImmunologyMitochondrial stress (mitostress) triggered by viral infection or mitochondrial dysfunction causes the release of mitochondrial DNA (mtDNA) into the cytosol and activates the cGAS-mediated innate immune response. The regulation of mtDNA release upon mitostress remains uncharacterized. Here, we identified mitochondria-associated...
Cited Boster Product(s): Mouse CXCL10/IP-10 ELISA Kit PicoKine™ (EK0736)
LncRNA SNHG6 Promotes G1/S-Phase Transition in Hepatocellular Carcinoma by Impairing miR-204-5p-Mediated Inhibition of E2F1
Authors: Chen, K., Hou, Y., Liao, R., Li, Y., Yang, H., Gong, J.
Journal: OncogeneEmerging evidence suggests that long noncoding RNAs (lncRNAs) function as competitive endogenous RNA (ceRNA) targeting proteins and genes; however, the role of lncRNAs in hepatocellular carcinoma (HCC) is not well understood. We investigated the mechanism by which lncRNA SNHG6 promotes the development of HCC. RT-qPCR revealed...
Cited Boster Product(s): RIPA Lysis Buffer (AR0105-100)
Exposure to Constant Light Impairs Cognition with FTO Inhibition and m6A-Dependent TrκB Repression in Mouse Hippocampus
Authors: Yang, Y., Feng, Y., Hu, Y., Liu, J., Shi, H., Zhao, R.
Journal: Environmental PollutionN6-methyladenosine (m6A) mRNA methylation plays a role in various brain functions. Exposure to chronic constant light (CCL) has been reported to impair cognition, yet whether the underlying mechanism involves m6A remains unknown. In this study, mice exposed to CCL for 3 weeks show impaired cognitive behavior, which was associated...
Cited Boster Product(s): HRP Conjugated Goat Anti-Mouse IgG SABC Kit (SA1021); HRP Conjugated Goat Anti-Rabbit IgG SABC Kit (SA1022)
...Increased Telomerase Activity in Major Depressive Disorder with Melancholic Features: Possible Role of Pro-Inflammatory Cytokines and the Brain-Derived Neurotrophic Factor
Authors: Çavuşoğlu, P.B., İscan, E., Güneş, A., Atabey, N., Alkın, T.
Journal: Brain, Behavior, & Immunity - HealthThe biological mechanisms responsible for depression symptoms are not yet understood. For this reason, it is important to reveal the etiopathogenetic mechanisms in this disease. This study aims to compare the levels of pro-inflammatory cytokines, Brain-Derived Neurotrophic Factor (BDNF), and telomerase activity in patients with major...
Cited Boster Product(s): Human IL-6
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The February edition of Research Spotlight provides 10 recent research discoveries from scientists whom Boster has served, which include new insights on the interactions between nanoparticles and human health as well as the underlying mechanisms.
The pathology-improvement effects of siRNA-based drugs on lung disorders, trichostatin A on Alzheimer’s disease, and propofol on microglial phagocytosis were also explored.
Scroll down to find out more about each featured publication.
...Combined Exposure of Alumina Nanoparticles and Chronic Stress Exacerbates Hippocampal Neuronal Ferroptosis via Activating IFN-γ/ASK1/JNK Signaling Pathway in Rats
Authors: Zhang, H., Jiao, W., Cui, H., Sun, Q., & Fan, H.
Journal : Journal of Hazardous MaterialsAlumina nanoparticles (AlNPs) exposure causes hippocampal-dependent cognitive dysfunction. However, whether chronic stress exacerbates AlNPs-induced hippocampal lesion and its mechanism remains unclear. This study was aimed to investigate the combined effects and mechanisms of AlNPs and chronic stress on the hippocampal lesion. The...
Cited Boster Product(s): Rat TNF Alpha ELISA Kit PicoKine™ (EK0526); Rat IL-1
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Our January edition of Research Spotlight presents an array of 10 interesting developments in the biomedical world. Valuable information about proliferation of cancer cells, immunity, inflammatory bowel diseases, and the body’s responses to oxidative stress and various nutrients are discussed.
In addition, scientists investigate how SLC19A1 as the major transporter of CDNs into cells could serve as a new potential immunotherapeutic treatment of cancer and some inflammatory diseases...
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In our September edition of Research Spotlight, we feature 10 recently published research papers from scientists whom Boster has served.
This month’s selected research publications examine the mechanisms of plaque rupture, ELABELA in DOCA/salt-induced hypertension, BMSC-derived exosomes in peripheral nerve regeneration, TMZ in diabetic nephropathy, and MCL on LPS-induced inflammation.
Among the studies, scientists also investigate nanomicelle’s effect on paclitaxel’s immune-activation ability. In addition, the connection of cancer-associated SNPs in lncRNA for lung cancer and the role of IL-6 for colorectal cancer are explored.
Scroll down to learn more about these new scientific discoveries.
...Nanomicelle protects the immune activation effects of Paclitaxel and sensitizes tumors to anti-PD-1 Immunotherapy
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