Boster Bio Life Science Blog

  1. Research Spotlight – February 2022

    In this month’s Research Spotlight, we highlight a range of our customers’ publications that investigate complex challenges and the development of life-changing innovations to improve patient health.

    February 2022

    In this month’s Research Spotlight, we highlight a range of our customers’ publications that investigate complex challenges and the development of life-changing innovations to improve patient health.

    Find out how tNIR light treatment might serve as a noninvasive therapeutic alternative for regulating neuronal functions via the improvement of mitochondrial dysfunction mediated by the SIRT1/PGC-1α pathway. In addition, as more studies reveal the key role of circRNAs in cancer, researchers dive deeper into the molecular mechanism of circRNAs in prostate cancer progression.

    In the fields of biomedicine and nanotechnology, scientists also successfully develop [email protected] and HRPS biomimetic nanoparticles that function as high targeting delivery systems for tumor immunotherapy and RA therapy, respectively.

    Scroll down to learn more about the various discoveries and their applications...

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    Research Spotlight – February 2022
  2. Research Spotlight - September 2021

    The September edition of Research Spotlight presents 10 recent publications from scientists whom Boster has served.

    This month’s selected research papers characterize the underlying mechanisms of several cancers, HIV, and other systemic diseases. Among the studies, monoclonal antibodies and a tumor nanovaccine are explored as therapeutic treatments for different cancers.

    Scientists also demonstrate how a 3D-printed biphasic scaffold can enhance cartilage regeneration. In addition, the role of PEDF in collagen synthesis and its implications for tissue expansion in plastic surgery is investigated.

    Keep scrolling to find out more about these research studies.

    Characterizing Dedifferentiation of Thyroid Cancer by Integrated Analysis

    Authors: Luo, H., Xia, X., Kim, G.D., Liu, Y., Xue, Z., Zhang, L., Shu, Y., Yang, T...
    Journal: Science Advances

    Understanding of dedifferentiation, an indicator of poo prognosis for patients with thyroid cancer, has been hampered by imprecise and incomplete characterization of its heterogeneity and its attributes. Using single-cell RNA sequencing, we explored the landscape of thyroid cancer at single-cell resolution with 46,205 cells and...

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    Cited Boster Product(s): Anti-Vimentin Antibody Picoband™ (PB9359); Anti-E Cadherin 1/CDH1 Antibody Picoband™ (PB9561)

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    Oral Immune Dysfunction is Associated with the Expansion of FOXP3+PD-1+Amphiregulin+ T Cells During HIV Infection

    Authors: Bhaskaran, N., Schneider, E., Faddoul, F., da Silva, A.P., Asaad, R...
    Journal: Nature Communications

    >Residual systemic inflammation and mucosal immune dysfunction persist in people living with HIV, despite treatment with combined anti-retroviral therapy, but the underlying immune mechanisms are poorly understood. Here we report that the altered immune landscape of the oral mucosa of HIV-positive patients on therapy involves...

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    Cited Boster Product(s): Human CD14 ELISA Kit PicoKine™ (EK0694); Human TLR2/Toll-Like Receptor 2 ELISA Kit PicoKine™ (EK0906); Human Cotinine ELISA Kit (Competitive EIA) (EK7035); Human Amphiregulin(AR) / AREG ELISA Kit PicoKine™ (EK0304); Human IL-1 Beta/IL-1F2/IL1B ELISA Kit PicoKine™ (EK0392); Human IL-6/Interleukin-6 ELISA Kit PicoKine™ (EK0410)

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    Increased Plasmin-Mediated Proteolysis of L1CAM in a Mouse Model of idiopathic Normal Pressure Hydrocephalus

    Authors: Yang, D., Yang, H., Luiselli, G., Ogagan, C., Dai, H., Chiu, L...
    Journal: PNAS (Proceedings of the National Academy of Sciences of the United States of America)

    Idiopathic normal pressure hydrocephalus (iNPH) is a common neurological disorder that is characterized by enlarged cerebral ventricles, gait difficulty, incontinence, and dementia. iNPH usually develops after the sixth decade of life in previously asymptomatic individuals. We recently reported that loss-of-function deletions in CWH43...

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    Cited Boster Product(s): Anti-Plasminogen Antibody Picoband™ (A03674-1)

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    Cooperating Minimalist Nanovaccine with PD-1 Blockade for Effective and Feasible Cancer Immunotherapy

    Authors: Jiang, M., Zhao, L., Cui, X., Wu, X., Zhang, Y., Guan, X., Ma, J...
    Journal: Journal of Advanced Research

    Introduction: Tumor vaccine has been a research boom for cancer immunotherapy, while its therapeutic outcome is severely depressed by the vulnerable in vivo delivery efficiency. Moreover, tumor immune escape is also another intractable issue, which has badly whittled down the therapeutic efficiency. Objectives: Our study aims to solve...

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    Cited Boster Product(s): FITC Conjugated Avidin (BA1125)

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    Blockade of CHRNB2 Signaling with a Therapeutic Monoclonal Antibody Attenuates the Aggressiveness of Gastric Cancer Cells

    Authors: Kanda, M., Shimizu, D., Nakamura, S., Sawaki, K., Umeda, S...
    Journal: Oncogene

    Here, we evaluated the therapeutic potential of antibodies (Abs) targeting cholinergic receptor nicotinic beta 2 subunit (CHRNB2) in gastric cancer. To investigate

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    Research Spotlight - September 2021
  3. Research Spotlight - March 2021

    In our March edition of Research Spotlight, we present 10 latest research papers from scientists whom Boster has served.

    Scientists explore the roles of various pathways associated with tumor development, and how they may emerge as new therapeutic targets for tumor metastasis. Several research studies also reveal the active role of gut microbiota in immunity and disease progressions as well as the effect of several compounds on the functionality and ecology of gut microbiome.

    Take a look below to learn more about these new research findings.

    Fecal Microbiota Transplantation in HIV: A Pilot Placebo-Controlled Study

    Authors: Serrano-Villar, S., Talavera-Rodríguez, A., Gosalbes, M.J., Madrid, N...
    Journal: Nature Communications

    Changes in the microbiota have been linked to persistent inflammation during treated HIV infection. In this pilot double-blind study, we study 30 HIV-infected subjects on antiretroviral therapy (ART) with a CD4/CD8 ratio less than 1 randomized to either weekly fecal microbiota capsules or placebo for 8 weeks. Stool donors were rationally...

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    Cited Boster Product(s): Human LB

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    Research Spotlight - March 2021
  4. Research Spotlight - January 2021

    Our January edition of Research Spotlight presents an array of 10 interesting developments in the biomedical world. Valuable information about proliferation of cancer cells, immunity, inflammatory bowel diseases, and the body’s responses to oxidative stress and various nutrients are discussed.

    In addition, scientists investigate how SLC19A1 as the major transporter of CDNs into cells could serve as a new potential immunotherapeutic treatment of cancer and some inflammatory diseases...

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    Research Spotlight - January 2021
  5. Research Spotlight - November 2020

    In our November edition of Research Spotlight, we feature 10 recently published research papers from scientists whom Boster has served.

    This month’s selected research publications investigate how several cells and mediators regulate the development of fibrotic diseases, cancer, inflammatory responses, diabetes, allergy, endometriosis, and anxiety.

    Among the studies, scientists propose the underlying mechanisms of how endothelin receptor antagonists may serve as a therapeutic strategy for fibrotic diseases. The role of PRMT5 in laryngeal tumor carcinogenesis is also explored.

    Discover more details about these new scientific discoveries below.

    Second-Strand Synthesis-Based Massively Parallel scRNA-Seq Reveals Cellular States and Molecular Features of Human Inflammatory Skin Pathologies

    Authors: Hughes, T.K., Wadsworth, M.H., Gierahn, T.M., Do, T., Weiss, D...
    Journal: Immunity

    High-throughput single-cell RNA-sequencing (scRNA-seq) methodologies enable characterization of complex biological samples by increasing the number of cells that can be profiled contemporaneously. Nevertheless, t

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    Research Spotlight - November 2020
  6. Research Spotlight – February 2019

    Our February edition of Research Spotlight features 10 recent research discoveries from scientists whom Boster has served.

    This month’s selected research publications investigate targets related to a number of cancers, such as osteosarcoma, hepatocellular carcinoma, pancreatic carcinoma, and glioblastoma, and also include studies that examine targets of Parkinson’s disease and type 2 diabetes mellitus.

    Scroll down to learn more about these new scientific discoveries.

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    Research Spotlight – February 2019
  7. Research Spotlight - January 2019

    The January edition of Research Spotlight features 10 recent research discoveries from scientists whom Boster has served.

    Scientists of this month’s selected research publications investigate various aspects of several pathways such as the MAPK, Wnt/β-catenin, TGF-β1/Smad3, NF-κB, Akt/mTOR, and AMPK/ULK1 signaling pathways.

    Scroll down to learn more about these new scientific discoveries.

    Luteolin inhibits IL-1β-induced inflammation in rat chondrocytes and attenuates osteoarthritis progression in a rat model

    Authors: Fei, J., Liang, B., Jiang, C., Ni, H., & Wang, L.
    Journal: Biomedicine & Pharmacotherapy

    Osteoarthritis (OA) is a joint disease characterized by inflammation and cartilage degradation. Accumulating evidence has demonstrated that luteolin, a natural flavonoid, has anti-inflammatory and anticatabolic effects. The present study...

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    Cited Boster Product(s): Rat TNF Alpha PicoKine™ ELISA Kit (EK0526); Rat MMP-2 PicoK

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    Research Spotlight - January 2019