Boster Bio Life Science Blog

  1. Research Spotlight - May 2022

    For this month’s Research Spotlight, we highlight 10 new research publications from scientists whom Boster has served.

    In the field of cancer immunotherapy, data from two studies point toward the anti-lymphoma and anti-bladder cancer effects exerted by ADAM10 and iDAMP inhibitors respectively. Additionally, scientists present the promising potential of CEACAM 5, PCL22-186, and lncSLCO1C1 as new biomarkers for predicting cancer cells’ radiosensitivity, cancer progression, and resistance...

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    Research Spotlight - May 2022
  2. Research Spotlight - April 2022

    Every month, we feature 10 research studies from scientists whom we have served. In our April edition of Research Spotlight, scientists focus on finding novel delivery systems to improve the poor delivery efficiency of therapeutic biomolecules.

    One research paper provided new insights into how renal exosomes are aroused by β-catenin, underscoring an important therapeutic strategy for CKD. Studies highlighting the promising potential of engineered EGCG-containing nanoassemblies, microalgae-based...

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    Research Spotlight - April 2022
  3. Research Spotlight – March 2022

    The March edition of Research Spotlight presents 10 recent publications from scientists whom Boster has served.

    In this edition, scientists discussed how a better understanding of the PD-L1 expression regulation can be pivotal in achieving better clinical outcomes in EBV-infected cancer patients. Another research study proposed a self-powered smart patch that serves as a reservoir of chemokine-/neural-directing exosomes, offering a serviceable strategy to stimulate skin neuro-engineering and regeneration of tissues and organs.

    In terms of bone diseases, one paper revealed the potential role of Calca, an osteoblast-derived ProCT in the bone microenvironment that is required to limit bone resorption during iPTH. Several development strategies in the fields of nanotechnology and biomaterials were also achieved through the construction of cell-responsive peptide assemblies and nanorod-like coating with ions doping.

    Explore below for a closer look at these research discoveries!

    EBV miRNAs BART11 and BART17-3p Promote Immune Escape Through the Enhancer-Mediated Transcription of PD-L1

    Authors: Wang, J., Ge, J., Wang, Y., Xiong, F., Guo, J., Jiang, X., Zhang, L…
    Journal: Nature Communications

    Epstein-Barr virus (EBV) is reportedly the first identified human tumor virus, and is closely related to the occurrence and development of nasopharyngeal carcinoma (NPC), gastric carcinoma (GC), and several lymphomas. PD-L1 expression is elevated in EBV-positive NPC and GC tissues; however, the specific mechanisms underlying the EBV-...

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    Cited Boster Product(s): Mouse IL-2 ELISA Kit PicoKine® (EK0398); Mouse Granzyme B ELISA Kit PicoKine® (EK1115); Mouse IFN Gamma / IFNG / Interferon Gamma ELISA Kit PicoKine® (EK0375)

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    MARCH3 negatively regulates IL-3-triggered inflammatory response by mediating K48-linked polyubiquitination and degradation of IL-3Rα

    Authors: Feng, L., Li, C., Zeng, L.W., Gao, D., Sun, Y.H., Zhong, L., Lin, H…
    Journal: Signal Transduction and Targeted Therapy

    Interleukin-3 (IL-3) is a hematopoietic growth factor and critical regulator of inflammatory response such as sepsis. IL-3 binds to IL-3 receptor α (IL-3Rα), which is then associated with IL-3Rβ to initiate signaling. How IL-3-triggered physiological and pathological effects are regulated at the receptor level is unclear. Here, we...

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    Research Spotlight – March 2022
  4. Research Spotlight - December 2021

    In our last edition of Research Spotlight this year, we're happy to feature 10 recent publications from scientists whom Boster has served.

    Among the studies, scientists investigate the mechanisms of m6a reader for colorectal cancer, the anti-metastatic roles of dsRNA mimics, and the effects of USP12 on breast cancer angiogenesis.

    In addition, scientists explore Vitamin D3's antioxidative stress ability as well as the lungfish cocoon's antimicrobial functions. Researchers also develop pitavastatin-loaded multilayer films that enhance osseointegration of metal implants.

    Scroll down to find out more about these discoveries!

    Vitamin D3 Protects Mice from Diquat-Induced Oxidative Stress through the NF-κB/Nrf2/HO-1 Signaling Pathway

    Authors: Zhang, H., Liu, Y., Fang, X., Gu, L., Luo, C., Chen, L., Wang, Q.
    Journal: Oxidative Medicine and Cellular Longevity

    Vitamin D3, as an indispensable and fat-soluble micronutrient, plays an important role in the health of humans and animals. At

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    Research Spotlight - December 2021
  5. Research Spotlight - November 2021

    Our November edition of Research Spotlight highlights 10 research studies that provide deeper insights on the biological functions of several key biomarkers and their clinical translational potential.

    Two studies reveal new insights for diabetes treatment by investigating the functions of PGRMC1 and an m6A reader protein for insulin metabolism and delayed diabetic wound healing respectively.

    Scientists also perform bioinformatics and immunological analysis of several regulatory...

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    Research Spotlight - November 2021
  6. Research Spotlight - March 2021

    In our March edition of Research Spotlight, we present 10 latest research papers from scientists whom Boster has served.

    Scientists explore the roles of various pathways associated with tumor development, and how they may emerge as new therapeutic targets for tumor metastasis. Several research studies also reveal the active role of gut microbiota in immunity and disease progressions as well as the effect of several compounds on the functionality and ecology of gut microbiome.

    Take a look below to learn more about these new research findings.

    Fecal Microbiota Transplantation in HIV: A Pilot Placebo-Controlled Study

    Authors: Serrano-Villar, S., Talavera-Rodríguez, A., Gosalbes, M.J., Madrid, N...
    Journal: Nature Communications

    Changes in the microbiota have been linked to persistent inflammation during treated HIV infection. In this pilot double-blind study, we study 30 HIV-infected subjects on antiretroviral therapy (ART) with a CD4/CD8 ratio less than 1 randomized to either weekly fecal microbiota capsules or placebo for 8 weeks. Stool donors were rationally...

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    Cited Boster Product(s): Human LB

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    Research Spotlight - March 2021
  7. Boster is a 2021 Bioz Stars Award Winner

    We are delighted to announce Boster Bio has been named a winner of the 2021 Bioz Stars Award for Antibodies! We’re proud to be supporting scientists worldwide to advance their research since 1993.

    Bioz Stars Awards are based on real-world measured successful product usage from over 33 million peer-reviewed scientific articles analyzed by Bioz’s patented AI technology. Winners are selected using data that generates objective product ratings and recommendations. Bioz’s AI platform exami...

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    Boster is a 2021 Bioz Stars Award Winner
  8. Research Spotlight - February 2021

    The February edition of Research Spotlight provides 10 recent research discoveries from scientists whom Boster has served, which include new insights on the interactions between nanoparticles and human health as well as the underlying mechanisms.

    The pathology-improvement effects of siRNA-based drugs on lung disorders, trichostatin A on Alzheimer’s disease, and propofol on microglial phagocytosis were also explored.

    Scroll down to find out more about each featured publication.

    Combined Exposure of Alumina Nanoparticles and Chronic Stress Exacerbates Hippocampal Neuronal Ferroptosis via Activating IFN-γ/ASK1/JNK Signaling Pathway in Rats

    Authors: Zhang, H., Jiao, W., Cui, H., Sun, Q., & Fan, H.
    Journal : Journal of Hazardous Materials

    Alumina nanoparticles (AlNPs) exposure causes hippocampal-dependent cognitive dysfunction. However, whether chronic stress exacerbates AlNPs-induced hippocampal lesion and its mechanism remains unclear. This study was aimed to investigate the combined effects and mechanisms of AlNPs and chronic stress on the hippocampal lesion. The...

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    Cited Boster Product(s): Rat TNF Alpha ELISA Kit PicoKine™ (EK0526); Rat IL-1

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    Research Spotlight - February 2021
  9. Research Spotlight - December 2020

    The December edition of Research Spotlight highlights 10 recent research discoveries from scientists whom Boster has served.

    In these studies, the effects of several key proteins and their signaling pathways were explored in correlation to the progression and activation of cancer cells, diabetic nephropathy, inflammation, and brain injury.

    The role of polysulfides as potential tumor suppressors and regulators might represent an alternative therapeutic candidate for the management of diabetic nephropathy. Additionally, several promising potential therapeutic strategies for enhanced immunotherapy, such as enhanced drug delivery systems, ultrasound-guided platelet-rich plasma injection, and the role of mechanical cues in vascular biology were also investigated.

    Scroll down to find more information about these new scientific discoveries.

    Polysulfide-Mediated Sulfhydration of SIRT1 Prevents Diabetic Nephropathy by Suppressing Phosphorylation and Acetylation of p65 NF-κB and STAT3

    Authors: Sun, H.J., Xiong, S.P., Cao, X., Cao, L., Zhu, M.Y., Wu, Z.Y., & Bian, J.S.
    Journal: Redox Biology

    Diabetic kidney disease is known as a major cause of chronic kidney disease and end stage renal disease. Polysulfides, a class of chemical agents with a chain of sulfur atoms, are found to confer renal protective effects in acute kidney injury. However, whether a polysulfide donor, sodium tetrasulfide (Na2S4), confers protective...

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    Cited Boster Product(s): Mouse TNF Alpha ELISA Kit PicoKine™ (EK0527); Mouse IL-1 Beta ELISA Kit PicoKine™ (EK0394); Mouse VCAM-1 ELISA Kit PicoKine™ (EK0538)

    Journal Cover

    Development of Thermosensitive Resiquimod-Loaded Liposomes for Enhanced Cancer Immunotherapy

    Authors: Zhang, H., Tang, W.L., Kheirolomoom, A., Fite, B.Z., Wu, B., Lau, K...
    Journal: Journal of Controlled Release

    Resiquimod (R848) is a toll-like receptor 7 and 8 (TLR7/8) agonist with potent antitumor and immunostimulatory activity. Howeve

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    Research Spotlight - December 2020
  10. Research Spotlight - November 2020

    In our November edition of Research Spotlight, we feature 10 recently published research papers from scientists whom Boster has served.

    This month’s selected research publications investigate how several cells and mediators regulate the development of fibrotic diseases, cancer, inflammatory responses, diabetes, allergy, endometriosis, and anxiety.

    Among the studies, scientists propose the underlying mechanisms of how endothelin receptor antagonists may serve as a therapeutic strategy for fibrotic diseases. The role of PRMT5 in laryngeal tumor carcinogenesis is also explored.

    Discover more details about these new scientific discoveries below.

    Second-Strand Synthesis-Based Massively Parallel scRNA-Seq Reveals Cellular States and Molecular Features of Human Inflammatory Skin Pathologies

    Authors: Hughes, T.K., Wadsworth, M.H., Gierahn, T.M., Do, T., Weiss, D...
    Journal: Immunity

    High-throughput single-cell RNA-sequencing (scRNA-seq) methodologies enable characterization of complex biological samples by increasing the number of cells that can be profiled contemporaneously. Nevertheless, t

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    Research Spotlight - November 2020