Histone-lysine N-methyltransferase EHMT2 (EHMT2)

Histone methyltransferase that specifically mono- and dimethylates'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones.

Also mediates monomethylation of'Lys-56' of histone H3 (H3K56me1) at G1 phase, leading to encourage interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me).