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Involved in many different effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B- cells. Binding to this receptor results in down-modulation of earlier state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or through another Fc receptor.
|Sequence:||1; NC_000001.11 (161647243..161678654)|
Is the most broadly distributed Fc-gamma- receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells.
Cell membrane; Single-pass type I membrane protein.