Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B)

Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor.

Involved in many different effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B- cells. Binding to this receptor results in down-modulation of earlier state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or through another Fc receptor.