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May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to behave through recruitment and/or stabilization of this Ubl-conjugating enzyme (E2) in the E3:substrate complex.
|Sequence:||X; NC_000023.11 (51802998..51902354)|
Expressed in bone marrow stromal cells from both multiple myeloma patients and healthy donors. Seems to be ubiquitously expressed.
Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus. Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF.