- Table of Contents
The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non- classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, possibly as components of transcriptional complexes, and may also be involved in signaling pathways in T- cells and neural cells.
|myelin basic protein family|
|Sequence:||18; NC_000018.10 (76978833..77133708, complement)|
MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system.
Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic side of myelin.; [Isoform 3]: Nucleus. Targeted to nucleus in oligodendrocytes.
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