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- Table of Contents
Neurofibromin Antibodies
AND NF1 ELISA kits, Neurofibromin Proteins
Many biological assays use antibodies to detect Neurofibromin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Neurofibromin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Neurofibromin antibodies...
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NF1 Infographic by Boster Bio
All NF1 Products
Product
Figures
Specificity
Applications
Price
Anti-Neurofibromin/NF1 Antibody Picoband®
1 Citations 1 Q&As
Human
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00043-1
100 μg/vial
Cat # A00043-1
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IHC, WB
$370
Cat # M00043
100 μg/vial
Cat # M00043
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00043-1
100 μg/vial
Cat # M00043-1
100 μg/vial
NF1 Overview
Facts about Neurofibromin.
Neurofibromin (NF1)
Stimulates the GTPase activity of Ras.
NF1 shows increased affinity for Ras GAP, but lower specific activity.Might be a regulator of Ras activity. .
Gene Information
| Human | |
|---|---|
| Gene Name: | NF1 |
| Uniprot: | P21359 |
| Entrez: | 4763 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
DKFZp686J1293; FLJ21220; Neurofibromatosis-related protein NF-1; neurofibromin 1; neurofibromin; NFNS; VRNF; WSS
Molecular Weight
Mass (kDA):
319.372 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q11.2 |
| Sequence: | 17; NC_000017.11 (31094927..31377677) |
Tissue Specificity
Detected in brain, peripheral nerve, lung, colon and muscle.
Subcellular Localizations
Nucleus. Nucleus, nucleolus.
Diseases
- Neurofibromatosis 1
- Neurofibromatoses
- Neoplasms
- Neurofibroma
- Malignant Paraganglionic Neoplasm
- Malignant Neoplasms
- Nerve Sheath Tumors
- Malignant Peripheral Nerve Sheath Tumor
- Cell Transformation, Neoplastic
- Glioma
- Leukemia
- Plexiform Neurofibroma
- Neurofibromatosis 2
Interacting Proteins
- APP
- HRAS
- SDC2
- SPRED1
Pathways
- Pathogenesis
- Cell Proliferation
- Cell Growth
- Localization
- Methylation
- Translation
- Cell Cycle
- Mismatch Repair
- Angiogenesis
- Cell Death
- Chromatin Remodeling
- Cell Differentiation
- Pigmentation
PTMs
- Phosphorylation
- Methylation
- Cleavage
- Acetylation
- Demethylation
- Dephosphorylation
- Farnesylation
Research Areas
- Cancer
- Cell Biology
- Cell Cycle and Replication
- Cellular Markers
- Chromatin Research
- Hypoxia
- Neuroscience
- Neurotransmission
- Signal Transduction
- Transcription Factors and Regulators
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NF1
bosterbio.com/bosterbio-gene-info-cards/NF1
References
PMID: 1457041 by Bernards A., et al. Complete human NF1 cDNA sequence: two alternatively spliced mRNAs and absence of expression in a neuroblastoma line.
PMID: 2134734 by Wallace M.R., et al. Type 1 neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patients.