Toll-like receptor 3 (TLR3)

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through comprehension of molecular patterns unique to germs.

TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, resulting in NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response.