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Facts about Tumor necrosis factor ligand superfamily member 13.
Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA.
Plays a role in the regulation of tumor cell growth.May be involved in monocyte/macrophage-mediated immunological processes. .
Human | |
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Gene Name: | TNFSF13 |
Uniprot: | O75888 |
Entrez: | 8741 |
Belongs to: |
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tumor necrosis factor family |
A proliferation-inducing ligand; APRIL; APRILFLJ57090; CD256 antigen; CD256; TALL2; TALL-2; TNF- and APOL-related leukocyte expressed ligand 2; TNF-related death ligand 1; TNFSF13; TRDL1; TRDL-1; tumor necrosis factor (ligand) superfamily, member 13; tumor necrosis factor ligand superfamily member 13; tumor necrosis factor-like protein ZTNF2; tumor necrosis factor-related death ligand-1; ZTNF2
Mass (kDA):
27.433 kDA
Human | |
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Location: | 17p13.1 |
Sequence: | 17; NC_000017.11 (7558292..7561608) |
Expressed at high levels in transformed cell lines, cancers of colon, thyroid, lymphoid tissues and specifically expressed in monocytes and macrophages.
Secreted.
It is essential to follow certain guidelines when using the Boster Bio platform. These guidelines can help you maximize your research and make the most of your data. To identify potential sources of error, and how to deal with these issues, you can refer the Boster bio troubleshooting guide. This guide is especially useful for those who are brand new to the Boster Bio platform as it will assist them in getting up and running quickly.
When you're optimizing an experiment for IHC it is important to know the various types of controls, which include concentrations of antibody and diluents. You should make use of the same diluents that you used in the standard curve for your experiment. An ELISA assay plate must be coated with high affinity antibodies to get the most effective signal. Boster Bio's guide to optimizing your ELISA will give specific instructions and will answer all your questions.
Boster Bio troubleshooting manuals are a great way to ensure that your experiments go smoothly. They can help you tackle the most common problems, and provide important insights into the most efficient possible experimental design. For example, Boster provides protocols that tackle the most commonly-asked questions encountered by researchers. The protocols can also serve as quick reference guides, or even as primers for those who are new to the field. In the case of antibody-based flow cytometry, the binding of an antibody to the surface antigen may stimulate cells or alter the expression of intracellular signalling proteins. Flow cytometry is a method of measuring Methanol or Saponin. Boster's protocols offer troubleshooting tips as well as optimization techniques.
A thorough review of the principle of immunohistochemistry assists users in optimizing the test and avoid common mistakes. The guide also provides recommendations for reagents and protocols. The guide also contains specific instructions for the preparation of different kinds of preserved tissues for optimal staining. Tissue preparation is vital in the process of IHC because the quality of the sample is the base of high-quality staining.
This product is an immunoglobulin-mAb that reacts with Human and Mouse CD40. The antibody is stable for one year and one month at -20 and 4degC at 4degC and -20, respectively. It is composed of 5 mg of BSA. You can purchase blocking peptides separately for varying prices depending on the immunogen length. For additional information, please look up the Boster Bio anti-CD40/Cd40 antibody Picoband(tm) product description.
The CD40 gene encodes an enzyme that is part of the TNF receptor superfamily. It is crucial for immune and inflammatory response. The transcription factor AT-hook AKNA regulates the expression of the CD40 receptor in various cell types. It is possible that there is the role of homotypic cell interactions in the regulation of CD40 receptor expression. The CD40 protein also interacts with the adaptor protein which is TNFR2.
PMID: 9743536 by Hahne M., et al. APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth.
PMID: 10331498 by Shu H.-B., et al. TALL-1 is a novel member of the TNF family that is down-regulated by mitogens.
*More publications can be found for each product on its corresponding product page