Boster's Picokine™ Eotaxin ELISA Kit provide high sensitivity low background quantitative detection of CCL11. It is an all-in-one ready to use kit with all components you need for performing colorimetric ELISA assay. Our 4-hour ELISA protocol saves you the trouble of coating the plate. Our kits are thoroughly validated and documented for inter and intra assay variability.
*ELISA bulk discount: 20% off for 4+ kits, 30% off for 20+ kits, applicable only to USA and Canada.
Eotaxin, also known as CCL11, is a potent inducer of eosinophil chemotaxis and is considered as a selective ligand of the CC chemokine receptor 3(CCR3), which is expressed on eosinophils, basophils, and Th2 lymphocytes. Eotaxin is assumed to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. The gene maps to chromosome 17 and is expressed constitutively at high levels in small intestine and colon, and at lower levels in various other tissues. The deduced mature protein sequence is 66% identical to human monocyte chemoattractant protein-1, and 60% identical to guinea pig eotaxin. Recombinant human eotaxin produced in insect cells induces a calcium flux response in normal human eosinophils, but not in neutrophils or monocytes. The human eotaxin gene is cloned and found to be 61.8 and 63.2% identical at the amino acid level to guinea pig and mouse eotaxin.