Boster's Picokine™ Rage ELISA Kit provide high sensitivity low background quantitative detection of AGER. It is an all-in-one ready to use kit with all components you need for performing colorimetric ELISA assay. Our 4-hour ELISA protocol saves you the trouble of coating the plate. Our kits are thoroughly validated and documented for inter and intra assay variability.
*ELISA bulk discount: 20% off for 4+ kits, 30% off for 20+ kits, applicable only to USA and Canada.
RAGE, the Receptor for Advanced Glycation Endproducts, is a 35kD transmembrane receptor of the immunoglobulin super family. It is also known as ?AGER?. AGER gene is mapped to chromosome 6p21.3 by mapping by contiguous cosmids and YAC clones and by fluorescence in situ hybridization. The expression of RAGE is particularly increased in neurons close to deposits of amyloid beta peptide and to neurofibrillary tangles. RAGE has been linked to several chronic diseases, which are thought to result from vascular damage. The pathogenesis is hypothesized to include ligand binding upon which RAGE signals activation of the nuclear factor kappa B(NF-kappaB).
|Pack Size:||96wells/kit, with removable strips.|
|Sample Type:||cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).|
|Availability:||Ships next business day|